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Repair not destruction: A new approach to treating retinopathy
November 17, 2006Many diseases of the eye (such as retinopathy of prematurity (ROP) and diabetic retinopathy) that result in loss of vision are the result of the growth of abnormal blood vessels that leak and bleed. Current treatments are designed to prevent the growth of these abnormal blood vessels. However, the authors of a study using a mouse model of retinopathy suggest that an alternative treatment strategy might be to repair these blood vessels so that they do not leak and bleed, causing loss of vision.
In the study, which appears online on November 16 in advance of publication in the December print issue of the Journal of Clinical Investigation, Martin Friedlander and colleagues from The Scripps Research Institute, La Jolla, show that the abnormal blood vessels that grow in the retina of mice exposed to a stimulus that induces retinopathy can be converted to normal blood vessels if the mice are transplanted with adult bone marrow-derived myeloid progenitor cells. Blood vessel repair occurred when the transplanted cells migrated to the eye and became cells known as microglial cells, it also required that the transplanted cells express a protein known as HIF-1-alpha.This study has clinical relevance because it suggests that transplantation of autologous bone marrow-derived progenitor cells might be a viable therapy for the treatment of human diseases that resemble this mouse model of retinopathy, such as ROP.
Journal of Clinical Investigation
Retinopathy Current Events and Retinopathy News RSSCataract surgery helps AMD patients; steroid improves DME; online eye health forum
This month's Ophthalmology, the journal of the American Academy of Ophthalmology (Academy) reports on a national study that finds cataract surgery is likely to benefit patients with age-related macular degeneration (AMD) at all stages of the disease, on a clinical trial showing that the steroid triamcinolone may be effective in advanced diabetic macular edema (DME) patients when standard treatment fails, and on the public's use of two Academy-sponsored online eye health forums.
Clues to visual variant Alzheimer's; myopia and diabetic retinopathy risk
Two studies are of particular note in today's Scientific Program of the 2009 Joint Meeting of the American Academy of Ophthalmology (AAO) and the Pan-American Association of Ophthalmology (PAAO): a report by Swiss neuro-ophthalmic researchers about vision exam clues that should make ophthalmologists suspect an atypical variant of Alzheimer's disease; and new evidence from a Singapore National Eye Center study that diabetics who are nearsighted may be less susceptible to diabetic retinopathy.
Treating ROP in tiny preemies; better glaucoma follow-up in urban clinic
Highlights of today's Scientific Program of the 2009 American Academy of Ophthalmology (AAO) - Pan-American Association of Ophthalmology (PAAO) Joint Meeting include: John T. Flynn, MD, Columbia University School of Medicine, discussing the ever-tougher challenges Eye M.D.s face in caring for the vision of the tiniest premature babies; and a report by Bradford W. Lee, MD, Stanford University School of Medicine, on barriers to glaucoma follow-up as perceived by patients in an urban, culturally diverse clinic.
First in New York: Bionic technology aims to give sight to woman blinded beginning at age 13
A 50-year-old New York woman who was diagnosed with a progressive blinding disease at age 13 was implanted with an experimental electronic eye implant that has partially restored her vision.
More infants surviving pre-term births results in higher rates of eye problems
As more extremely pre-term infants survive in Sweden, an increasing number of babies are experiencing vision problems caused by abnormalities involving the retina.
New device finds early signs of eye disease in preemies
Tell-tale signs of a condition that can blind premature babies are being seen for the first time using a new handheld device in a study at Duke University Medical Center.
Rare genetic disease successfully reversed using stem cell transplantation
A recent study by Scripps Research Institute scientists offers good news for families of children afflicted with the rare genetic disorder, cystinosis.
Elevated arginase levels contribute to vascular eye disease such as diabetic retinopathy
Elevated levels of the enzyme arginase contribute to vascular eye damage and Medical College of Georgia researchers say therapies to normalize its levels could halt progression of potentially blinding diseases such as diabetic retinopathy.
Anti-growth factor drugs raise hope and concern for treatment of children's eye diseases
A new class of antibody drugs may provide a powerful new tool for the treatment of eye diseases in children, but specialists need to be alert for the possibility of serious side effects, according to an editorial in the August Journal of AAPOS (American Association for Pediatric Ophthalmology and Strabismus), published by Elsevier.
Natural Compound Stops Diabetic Retinopathy
Researchers at the University of Oklahoma Health Sciences Center have found a way to use a natural compound to stop one of the leading causes of blindness in the United States.
More Retinopathy Current Events and Retinopathy News Articles
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Diabetic Retinopathy: A Guide for Diabetes Care Teams by William D. Alexander (Editor) Western General Hospital NHS Trust, Edinburgh, UK. Provides a review of the examination of the eye in diabetes, retinopathy assessment, referral procedures, screening programs, management of diabetic retinopathy, and more. Color illustrations. Trim size: 8.5 x 5.5 inches. Softcover. |
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Diabetic Retinopathy for the Comprehensive Ophthalmologist by Jonathan D. Walker (Author), Lauren Fath (Editor), M. Walt Keys (Editor) This book is designed to transfer useful skills for the clinical management of diabetic patients. The target audience is residents, beginning retina fellows and comprehensive ophthalmologists interested in fine-tuning their approach to diabetic retinopathy. Further information and sample downloads of the book are available at drcobook.com |
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Diabetic Retinopathy: Current Management of the Patient with Cerebral Ischemia: Update Total Joint Replacement--VHS Videotape, The Network for Continuing Medical Education. Includes guide pamphlet. | |
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Understanding Diabetic Retinopathy |
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Vitreoretinal Surgery on Video, Tapes 1-4: 1:Retinal Detachment combined with Proliferative Vitreo Retinopathy (PVR) I2:Retinal Detachment combined with ... Tears (GRT)4:Traumatic Retinal Detachment I [VHS] Starring: R. Zivojnovic | |
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Nature Made Selenium Supplement Tablets, 200 mcg, 100-Count Bottles (Pack of 3) by Nature Made An antioxidant that complements Vitamin E to help protect cells from free radicals thought to be responsible for cellular damage. |
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Large Print USB Computer Keyboard (White with Black Letters) for Visually Impaired Individuals by Keys-U-See Keys-U-SeeTM large print keyboards are perfect for anybody who has a hard time seeing the letters on their computer keyboards. The Key Connection's large print computer keyboards are also great for anyone who works in low light conditions or is learning to type. Our large print keyboards come in a variety of colors including our specialty keyboard designed with yellow keys and black type - a scientifically proven combination that helps those with certain types of visual impairment. What types of visual impairment can Keys-U-SeeTM large print keyboards help with? * Macular Degeneration * Glaucoma * Diabetic Retinopathy * Cataracts * Normal Aging * Retinitis Pigmentosa |
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Papilledema Retinopathy Photographic Poster Print, 24x18 by AllPosters.com AllPosters.com is the world's #1 seller of posters, prints, photographs, specialty products and framed art. We're dedicated to bringing our customers the best selection of high quality wall décor that is perfect for their home or office. Browse our catalog of over 300,000 items that include entertainment and specialty posters, decorative prints, and art reproductions. Whether you're looking for your favorite movie or music poster, a framed Monet reproduction, or a print of the Eiffel Tower you will find it at AllPosters.com. Visit our Amazon store today at www.amazon.com/allposters to find Special Offers and search by subject category or artist. AllPosters.com provides unmatched service with a 100% satisfaction guarantee. We ship internationally to over 80 countries. Decorate your... |
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Diabetic Retinopathy (Contemporary Diabetes) by Elia Duh (Editor) Diabetic retinopathy is the most common microvascular complication of diabetes. It remains a major cause of new-onset visual loss in the United States and other industrialized nations. In Diabetic Retinopathy, Elia Duh and a panel of internationally recognized experts comprehensively assess the current state of knowledge regarding the clinical management of DR as well as its underlying mechanisms. The authors outline the current understanding of diabetic retinopathy from the perspective of clinical practice, while reviewing the multi-factorial pathogenesis and pathophysiology of DR from the standpoint of biomedical research. Also included is a discussion of emerging concepts relating to the management and treatment of DR. Informative and highly-practical, Diabetic Retinopathy provides... |
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A Practical Manual of Diabetic Retinopathy Management (Practical Manual of Series) by Peter Scanlon (Author), Stephen Aldington (Author), Charles Wilkinson (Author), David Matthews (Author) This practical clinical manual covers the diagnosis, treatment - both medical and surgical - and long-term management of eye problems in people with diabetes. Aimed at the MDT involved in the care of patients with diabetes, it emphasizes the importance of regular screening and early diagnosis and presents evidence-based guidance. |
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