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Quest for better breast cancer drugs
November 28, 2006Breast cancer sufferers could eventually benefit from high-tuned, tailor-made drug treatments that minimise side effects as a result of a joint initiative between computer scientists in Edinburgh and cellular biologists in Japan.
The five-year project, which involves the University of Edinburgh and the Riken Genomic Research Centre in Japan, will initially look at why particular treatments for breast cancer work in some patients and not in others.
It will use advanced computer systems set up at the University of Edinburgh's School of Informatics to run programmes incorporating expertise from cellular biologists in Japan to better understand the make-up of particular drugs and why their effectiveness differs among patients.
It is hoped that the database, which will use clinical information from patients at the Edinburgh Breast Unit and Cancer Research Centre, will be able to narrow down the different types of drugs that should be prescribed to individual patients and what types of combination therapy would have the best outcome.
The database could also provide information for creating new drugs, with computer modelling becoming an integral part of medical research.
Igor Goryanin, director of the Edinburgh Centre for Bioinformatics, based at the University, said: "The computer systems will help the biologist to understand the function of the organisms and, with this knowledge, we will be able to predict more accurately which new and existing drugs work and why.
"We would hope to further our research further and look at other cancers as well as diseases such as heart disease and neural and psychiatric diseases. Identifying which drugs have the best responses in particular patients would not only save lives but would also save the NHS money as treatment with expensive drugs can be tailor-made for whom it works."
University of Edinburgh
It is hoped that the database, which will use clinical information from patients at the Edinburgh Breast Unit and Cancer Research Centre, will be able to narrow down the different types of drugs that should be prescribed to individual patients and what types of combination therapy would have the best outcome.
The database could also provide information for creating new drugs, with computer modelling becoming an integral part of medical research.
Igor Goryanin, director of the Edinburgh Centre for Bioinformatics, based at the University, said: "The computer systems will help the biologist to understand the function of the organisms and, with this knowledge, we will be able to predict more accurately which new and existing drugs work and why.
"We would hope to further our research further and look at other cancers as well as diseases such as heart disease and neural and psychiatric diseases. Identifying which drugs have the best responses in particular patients would not only save lives but would also save the NHS money as treatment with expensive drugs can be tailor-made for whom it works."
University of Edinburgh
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Researchers Identify Role of Gene in Tumor Development, Growth and Progression
Virginia Commonwealth University Massey Cancer Center and VCU Institute of Molecular Medicine researchers have identified a gene that may play a pivotal role in two processes that are essential for tumor development, growth and progression to metastasis.
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Drugs to treat anemia in cancer patients linked to thromboembolism
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Discovery in worms by Queen's researchers points to more targeted cancer treatment
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FDA approved leukemia drugs shows promise in ovarian cancer cells
The drug Sprycel, approved for use by the U.S. Food and Drug Administration in patients with chronic myeloid leukemia, significantly inhibited the growth and invasiveness of ovarian cancer cells and also promoted their death, a study by researchers with UCLA's Jonsson Comprehensive Cancer Center found.
Carnegie Mellon researchers link health-care debate to risk of dying in US and Europe
The current health care debate in the United States is complicated. Trade-offs between heath care expenditures, lifestyle choices and life expectancy have been suggested but seldom clearly demonstrated.
Scientists uncover new key to the puzzle of hormone therapy and breast cancer
The use of postmenopausal hormone therapy has decreased over time in the United States, which researchers suggest may play a key role in the declining rate of atypical ductal hyperplasia, a known risk factor for breast cancer.
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