 |
|
Don't move a muscle: Evolutionary insight into myogenesis
December 07, 2006In a paper released online ahead of its scheduled December 15th publication date, Dr. Michael Krause (NIH) and colleagues detail the transcription network that drives muscle development in the roundworm C. elegans, and make a strong argument for an evolutionarily conserved program of myogenesis in all animals. Dr. Krause and colleagues demonstrate that three transcription factors - HLH-1, UNC-120 and HND-1 - redundantly control body wall muscle development in C. elegans. As the corresponding mammalian factors play important roles in directing vertebrate myogenesis, the authors propose that all animal muscle cell types (skeletal, smooth and cardiac muscle in vertebrates; and bodywall, smooth and cardiac/pharyngeal muscle in invertebrates) have arisen from a common ancestral precursor. Dr. Krause emphasizes that "understanding the redundancy built into worm muscle development reveals that the core transcriptional regulators of myogenesis are, as we would predict, conserved across animals."
Cold Spring Harbor Laboratory
Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
In an upcoming issue of G&D, Drs. Maria Divina Deato and Robert Tjian (HHMI, UC Berkeley) reveal that the formation of an alternative transcriptional core promoter complex directs cell-type specific differentiation during myogenesis.
Gene silencing directs muscle-derived stem cells to become bone-forming cells
Using a relatively new technology called RNA interference to turn off genes that regulate cell differentiation, University of Pittsburgh researchers have demonstrated they can increase the propensity of muscle-derived stem cells (MDSCs) to become bone-forming cells.
Masterminding muscle development
Dr. Lizi Wu (Dana Farber Cancer Institute) and colleagues report on a critical role for one of the three mammalian mastermind genes (Maml1) in myogenesis - assigning that first biological function to the mammalian MAML Notch co-activators.
Genetics of muscular dystophy
Various forms of human muscular dystrophy result from mutations in genes encoding proteins of the nuclear envelope. A new paper in the February 15th issue of G&D reveals how.
More Myogenesis Current Events and Myogenesis News Articles
|
Regeneration of Striated Muscle and Myogenesis by Alexander Mauro (Editor), etc. (Editor) | |
|
Science, 21 June 1963, Articles on Clonal Analysis of Myogenesis, Can the Direction of Flow of Time Be Determined?, Ecdysone, Cretaceous, Paleocene, and Pleistocene Sediments from the Indian Ocean, Ozone Damage, and Much More! by American Association for the Advancement of Science. (Author) | |
|
Frontiers in Muscle Research: Myogenesis, Muscle Contraction and Muscle Dystrophy : Proceedings of the Uehara Memorial Foundation Symposium on Front (International Congress Series) by Uehara Memorial Foundation Symposium on Frontiers in Muscle Research (Author), Tomoh Masaki (Author), Eijiro Ozawa (Author), Yoichi Nabeshima (Author), Yoichi Nabeshima (Editor) Researchers from various fields of muscle cell study gathered to exchange new knowledge and to show new trends in muscle sciences to the younger generation of scientists. Today, muscle research has many facets, i.e. induction of muscle from more immature tissues, control of gene expression, formation of organelles such as myofibrils, and contraction and maintenance of muscle cells. The constructive presentations and discussions presented by leading researchers in these various fields makes this book a reflection of the frontiers, and the developments in muscle science in 1990. | |
 |
Elucidating the Epistatic Network of Cardiac and Skeletal Myogenesis by Peter Gianakopoulos (Author), Ilona Skerjanc (Author), Helen Petropoulos (Author) The striated muscle forming regions in the vertebrate embryo respond to extra-cellular signals emitted from surrounding structures. Subsequently, genetic programs are activated in these tissues; ultimately forming cardiac or skeletal myocytes. P19 are embryonal carcinoma cells that can differentiate into beating myocardium and multi-nucleated skeletal myotubes that are biochemically and physiologically similar to in vivo tissues. MyoD (a member of the Myogenic Regulatory Factors (MRFs)), Sonic Hedgehog (Shh), Gli2 and Meox1 play roles in the commitment of cells into the skeletal muscle lineage. To further define their roles in regulating skeletal myogenesis, MyoD, Shh, Gli2 and Meox1 were examined in the context of differentiating P19 cells. |
|
Cell: Volume 56 Number 4 February 24, 1989; Homologies in Genes Family Regulating Myogenesis by Cell Press (Publisher) | |
 |
Vertebrate Myogenesis (Results and Problems in Cell Differentiation) by Beate Brand-Saberi (Editor) The development of vertebrate muscle has long been a major area of research in developmental biology. During the last decade, novel technical approaches have allowed us to unravel to a large extent the mechanisms underlying muscle formation, and myogenesis has become one of the best-understood paradigms for cellular differentiation. This book concisely summarizes our current knowledge about muscle development in vertebrates, from the determination of muscle precursors to terminal differentiation. Each chapter has been written by an expert in the field, and particular emphasis has been placed on the different developmental and molecular pathways followed by the three types of vertebrate musculature - skeletal, heart and smooth muscle. |
 |
Stem Cells and Cell Signalling in Skeletal Myogenesis, Volume 11 (Advances in Developmental Biology and Biochemistry, V. 11) by D.A. Sassoon (Editor) Skeletal muscle development is perhaps one of the best understood processes at the molecular, cellular and organismal level due in large part to the fact that primary myogenic cells (myoblasts) will grow and subsequently differentiate into myotubes in culture. With the advent of reverse mouse genetics, many of the observations gained through the study of myogenic cells in vitro have been directly tested in vivo. What has emerged is a complex but cohesive story of how myogenic cells are initially specified in the vertebrate embryo and how muscle fibers ultimately achieve their respective identities (i.e. fast versus slow) to perform their function. This collection of chapters is focused on these developments. The book discusses old and new directions for the skeletal muscle field and... |
|
Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems by Antonio Giordano (Editor), Umberto Galderisi (Editor) Complex physiopathological relationships have been proven to exist between two of the body’s most vital organs; the brain and the heart. In Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems Antonio Giordano, Umberto Galderisi and a panel of the most respected authorities in their field offer an in-depth analysis of the differentiation process in two systems that have profound relationships with one another. The text looks at several aspects of the cardiovascular and nervous systems from a new point of view, describing the differences and similarities in their differentiation pathways with an emphasis on the role of cell cycle regulation and cell differentiation. Topics discussed include neurogenesis in the central nervous system, neural stem cells, and... | |
![Microarray gene expression profiling during the segmentation phase of zebrafish development [An article from: Comparative Biochemistry and Physiology, Part C]](http://ecx.images-amazon.com/images/I/51A51TBEEML._SL160_.jpg) |
Microarray gene expression profiling during the segmentation phase of zebrafish development [An article from: Comparative Biochemistry and Physiology, Part C] by E. Linney (Author), B. Dobbs-McAuliffe (Author), H. Sajadi (Author), R Malek (Author) This digital document is a journal article from Comparative Biochemistry and Physiology, Part C, published by Elsevier in 2004. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: We analyzed 15,512 unique transcripts from wild-type Danio rerio using a long oligonucleotide microarray containing >16,000 65-mers probes. Total RNA was isolated from staged embryos at 2 h intervals over a 24-h period. On average, at any given time point, 27% of the probe set detected corresponding transcripts in embryonic RNA. There were two predominant patterns in the nearly 4000 genes that changed expression in at least one time point during the first 24 hpf. At 12 hpf, we detected... |
|
Alteration of terminal myogenesis by the carcinogen ethane methylsulfonate: A dissertation in anatomy by Parker Bruce Antin (Author) |
| © 2009 BrightSurf.com |