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Structural mechanism of the E. coli drug efflux pump AcrB
December 27, 2006In a new study published online in the open access journal PLoS Biology, Gaby Sennhauser, Marcus Gruetter, and colleagues use structural biology techniques to probe the molecular mechanisms of the major drug efflux pump in E. coli AcrB.
Bacterial resistance to antibiotics is a major challenge for the current treatment of infectious diseases. One way bacteria can escape destruction is by pumping out administered drugs through specific transporter proteins that span the cell membrane, such as AcrB.
Each subunit has a differently shaped substrate transport channel; these variable channels provide unique snapshots of the different phases employed by AcrB during transport of a substrate. The structure also offers an explanation for how substrate export is structurally coupled to simultaneous proton import-thus significantly improving our understanding of the mechanism of AcrB. This is the first report of the selection and co-crystallization of a DARPin with a membrane protein, which demonstrates not only DARPins' potential as inhibitors, but also as tools for the structural investigation of integral membrane proteins.
Public Library of Science
Biology Current Events and Biology News RSSNew chameleon species discovered in East Africa
Dr Andrew Marshall, from the Environment Department at the University of York, first spotted the animal while surveying monkeys in the Magombera Forest when he disturbed a twig snake eating one.
The cause behind the characteristic shape of a long leaf revealed
Applied mathematicians dissected the morphology of the plantain lily (Hosta lancifolia), a characteristic long leaf with a saddle-like arc midsection and closely packed ripples along the edges.
Time of day matters to thirsty trees, U of T researcher discovers
The time of day matters to forest trees dealing with drought, according to a new paper produced by a research team led by Professor Malcolm Campbell, University of Toronto Scarborough's vice-principal for research and colleagues in the department of cell and systems biology at the St. George campus.
Possible Link Studied Between Childhood Abuse and Early Cellular Aging
Children who suffer physical or emotional abuse may be faced with accelerated cellular aging as adults, according to new research from Butler Hospital and Brown University.
Rare pancreatic cancer patients may live longer when treated with radiation therapy
Radiation therapy is effective in achieving local control and palliation in patients with pancreatic neuroendocrine tumors (PNTs), despite such tumors being commonly considered resistant to radiation therapy.
Saving the single cysteine: new antioxidant system found
We've all read studies about the health benefits of having a life partner. The same thing is true at the molecular level, where amino acids known as cysteines are much more vulnerable to damage when single than when paired up with other cysteines.
Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer
Agios Pharmaceuticals today announced that its scientists have established, for the first time, that the mutated IDH1 gene has a novel enzyme activity consistent with a cancer-causing gene, or oncogene.
Scientists at UA, collaborating institutions decode maize genome
Scientists from the University of Arizona led by Arizona Genomics Institute director Rod A. Wing and from collaborating institutions have deciphered the complete genetic code of the maize plant for the first time.
Ancestry attracts, but love is blind
People preferentially marry those with similar ancestry, but their decisions are not necessarily based on hair, eye or skin colour.
Scientists unlock clues for tailoring corn plant for food, energy needs
Scientists have long known that the offspring of two inbred strains tend to be superior to both their parents. Now, a team of researchers including a University of Florida geneticist has discovered clues to why that might be the case for one of the most important crops in the world: corn.
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Biology with MasteringBiology (8th Edition) by Neil A. Campbell (Author), Jane B. Reece (Author) The best-selling biology textbook in the world just got better! Neil Campbell and Jane Reece’s BIOLOGY is the unsurpassed leader in introductory biology. The book's hallmark values–accuracy, currency, and passion for teaching and learning–have made Campbell/Reece the most successful book for readers for seven consecutive editions. More than 6 million readers have benefited from BIOLOGY’sclear explanations, carefully crafted artwork, and student-friendly narrative style. Introduction: Themes in the Study of Life, The Chemical Context of Life, Water and the Fitness of the Environment, Carbon and the Molecular Diversity of Life, The Structure and Function of Large Biological Molecules, A Tour of... |
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Biology, 7th Edition (Book & CD-ROM) by Neil A. Campbell (Author), Jane B. Reece (Author) Neil Campbell and Jane Reece's BIOLOGY remains unsurpassed as the most successful majors biology textbook in the world. This text has invited more than 4 million students into the study of this dynamic and essential discipline.The authors have restructured each chapter around a conceptual framework of five or six big ideas. An Overview draws students in and sets the stage for the rest of the chapter, each numbered Concept Head announces the beginning of a new concept, and Concept Check questions at the end of each chapter encourage students to assess their mastery of a given concept. New Inquiry Figures focus students on the experimental process, and new Research Method Figures illustrate important techniques in biology. Each chapter ends with a Scientific Inquiry Question that asks... |
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Biology by Peter Raven (Author), George Johnson (Author), Kenneth Mason (Author), Jonathan Losos (Author), Susan Singer (Author) Take a New Look at Raven! BIOLOGY is an authoritative majors textbook focusing on evolution as a unifying theme. In revising the text, McGraw-Hill consulted with numerous users, noted experts and professors in the field. Biology is distinguished from other texts by its strong emphasis on natural selection and the evolutionary process that explains biodiversity. The new 8th edition continues that tradition and advances into modern biology by featuring the latest in cutting edge content reflective of the rapid advances in biology. That same modern perspective was brought into the completely new art program offering readers a dynamic, realistic, and accurate, visual program. To view a sample chapter, go to www.ravenbiology.com |
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Student Study Guide for Biology by Neil A. Campbell (Author), Jane B. Reece (Author), Martha R. Taylor (Author) This printed learning aid provides a concept map of each chapter, chapter summaries, word roots, chapter tests, and a variety of interactive questions including multiple-choice, short-answer essay, labeling art, and graph-interpretation questions. |
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Biology: A Self-Teaching Guide, 2nd edition by Steven Daniel Garber (Author) A complete course, from cells to the circulatory system Hundreds of questions and many review tests Key concepts and terms defined and explained Master key concepts. Answer challenging questions. Prepare for exams. Learn at your own pace. Are viruses living? How does photosynthesis occur? Is cloning a form of sexual or asexual reproduction? What is Anton van Leeuwenhoek known for? With Biology: A Self-Teaching Guide, Second Edition, you’ll discover the answers to these questions and many more. Steven Garber explains all the major biological concepts and terms in this newly revised edition, including the origin of life, evolution, cell biology, reproduction, physiology, and botany. The step-by-step, clearly structured format of Biology... |
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Biology: Concepts and Connections (6th Edition) by Neil A. Campbell (Author), Jane B. Reece (Author), Martha R. Taylor (Author), Eric J. Simon (Author), Jean L. Dickey (Author) Biology: Concepts & Connections, 6/e continues to be the most accurate, current, and pedagogically effective book on the market. This extensive revision builds upon the book’s best-selling success with exciting new and updated features. KEY TOPICS: THE LIFE OF THE CELL, The Chemical Basis of Life, The Molecules of Cells, A Tour of the Cell, The Working Cell, How Cells Harvest Chemical Energy, Photosynthesis: Using Light to Make Food, The Cellular Basis of Reproduction and Inheritance, Patterns of Inheritance, Molecular Biology of the Gene, How Genes Are Controlled, DNA Technology and Genomics, How Populations Evolve, The Origin of Species, Tracing Evolutionary History, The Origin and Evolution of Microbial Life: Prokaryotes and Protists, Plants, Fungi, and... |
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Prentice Hall Biology by Kenneth R. Miller (Author), Joseph S. Levine (Author) |
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Biology by Peter Raven (Author), George Johnson (Author), Susan Singer (Author), Jonathan Losos (Author) BIOLOGY is an authoritative majors textbook with evolution as a unifying theme. In revising the text, McGraw-Hill has consulted extensively with previous users, noted experts and professors in the field. It is distinguished from other texts by its strong emphasis on natural selection and the evolutionary process that explains biodiversity. |
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CliffsAP Biology (Cliffs Ap Biology) by Phillip E. Pack Ph.D. (Author) Your complete guide to a higher score on the AP Biology exam. Included in book: A review of the AP exam format and scoring, proven strategies for answering multiple-choice questions, and hints for tackling the essay questions. A list of 14 specific must-know principles are covered. Includes sample questions and answers for each subject Laboratory Review includes a focused review of all 12 AP laboratory exercises. AP Biology Practice Tests features 2 full-length practice tests that simulate the actual test along with answers and complete explanations. AP is a registered trademark of the College Board, which was not involved in the production of, and does not endorse, this product. |
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Study Guide for Biology by Martha R. Taylor (Author) by Martha R. Taylor. This printed learning aid provides a concept map of each chapter, chapter summaries, word roots, chapter tests, and a variety of interactive questions including multiple-choice, short-answer essay, labeling art, and graph-interpretation questions. |
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