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Glucose levels trigger compensation for type 2 diabetics
January 03, 2007Many individuals with type 2 diabetes are diabetic because the cells of their body no longer respond to the hormone insulin, which is crucial for lowering blood sugar levels (blood glucose levels). However, before individuals become clinically diabetic their body tries to compensate for the increasing resistance to the effects of insulin by increasing both the amount of insulin secreted and the mass of insulin-secreting cells (beta cells) in the pancreas. Several factors have been shown to induce an increase in beta-cell mass, but exactly what triggers this in individuals consuming a high-fat diet has not been clearly established.
In a study appearing in the January issue of the Journal of Clinical Investigation, Takashi Kadowaki and colleagues from the University of Tokyo, Japan, show that in mice with high-fat diet-induced insulin resistance, changes in glucose concentration are likely to be the main trigger of increased beta-cell mass. The beta-cell mass of mice expressing only one copy of the gene encoding the sensor of blood glucose levels, GCK (Gck-/- mice), showed little increase compared with wild-type mice fed a high-fat diet, and the mice developed diabetes. One important mediator of the beta-cell mass increase downstream of GCK sensing increased blood glucose levels, and was shown to be IRS2, as expression of IRS2 in Gck-/- mice partially prevented diabetes by increasing beta-cell mass. The authors therefore suggest that novel strategies to increase beta-cell mass to treat type 2 diabetes and overcome high-fat diet-induced insulin resistance might be developed if the mechanism linking GCK and IRS2 can be determined. However, in an accompanying commentary, Gordon Weir and Susan Bonner-Weir from the Joslin Diabetes Center remind us that before we develop new therapeutics "it is essential that glucose signals involved in beta-cell replication in both health and disease be carefully defined."
Journal of Clinical Investigation
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Scientists have long known that the offspring of two inbred strains tend to be superior to both their parents. Now, a team of researchers including a University of Florida geneticist has discovered clues to why that might be the case for one of the most important crops in the world: corn.
Scripps research scientists find new link between insulin and core body temperature
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Cancers' Sweet Tooth May Be Weakness
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Scientists find molecular trigger that helps prevent aging and disease
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Night Beat, Overtime and a Disrupted Sleep Pattern Can Harm Officers' Health
A police officer who works the night shift, typically from 8 p.m. to 4 a.m., already is at a disadvantage when it comes to getting a good "night's" sleep.
Fat collections linked to decreased heart function
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New study links vitamin D deficiency to cardiovascular disease and death
While mothers have known that feeding their kids milk builds strong bones, a new study by researchers at the Heart Institute at Intermountain Medical Center in Salt Lake City suggests that Vitamin D contributes to a strong and healthy heart as well - and that inadequate levels of the vitamin may significantly increase a person's risk of stroke, heart disease, and death, even among people who've never had heart disease.
Researchers discover mechanism of insulin production that can lead to better treatment for diabetes
How a specific gene within the pancreas affects secretion of insulin has been discovered by researchers from the Hebrew University of Jerusalem, in collaboration with Japanese and American universities.
New paper describes connections between Circadian and metabolic systems
A paper by University of Notre Dame biologist Giles Duffield and a team of researchers offers new insights into a gene that plays a key role in modulating the body's Circadian system and may also simultaneously modulate its metabolic system.
Sweet as can be: how E. coli gets ahead
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Bayer's Contour Blood Glucose Monitoring System by Ascensia Bayer HealthCare LLC does not warrant use of the Ascensia Contour Blood Glucose Meter with any strip other than Ascensia Contour Blood Glucose Strips. For complete warranty information, refer to User Guide. For in vitro diagnostic use. Store meter at room temperature 50 -86° Fahrenheit. This kit contains the following Ascensia Contour items: *Blood Glucose Meter*Quick Reference Guide*User Guide*Ascensia Microlet Adjustable Lancing Device with 5 lancets*Ascensia Clinilog record Diary*Carrying case*Warranty card. Satisfaction guaranteed or your money back within 90 days of purchase. Five year limited warranty. For questions or comments, or help with reimbursement, call: 1-800-348-8100, or www.bayerdiabetes.com. Bayer HealthCare LLC is dedicated to providing the highest quality products and... |
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The New Glucose Revolution Shopper's Guide to GI Values 2009: The Authoritative Source of Glycemic Index Values for More than 1,250 Foods by Jennie Brand-Miller (Author), Kaye Foster-Powell (Author) Whether you’re grocery shopping, planning dinner, eating out, or meeting with your nutritionist or dietitian, the fourth annual edition of the Shopper’s Guide to GI Values 2009—previous editions of which have sold more than 140,000 copies—is a must for everyone seeking healthier eating habits. Newly revised and updated, the convenient, at-a-glance tables make this the one necessary guide for people following the glycemic index (GI) for health conditions such as diabetes, heart disease, or PCOS; to lose weight; or to improve their overall well-being and fitness. Shopper’s Guide is the only annually updated book of GI values, featuring more than 1,200 foods and their GI values and comprehensive nutritional data for calories, fat, saturated fat, cholesterol, fiber, and... |
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Polycose Glucose Polymer Module Powder, Unflavored, 12.3-Ounce Cans (Pack of 6) by Polycose Polycose is an easily digestible source of carbohydrate calories for use when additional calories are required. It mixes easily with regular foods and beverages to provide extra calories for persons with increased caloric needs or for those whose normal diet does not meet their needs. POLYCOSE Glucose Polymers may be used indefinitely as an enteral carbohydrate supplement. Although POLYCOSE may serve temporarily as the sole energy source, it is not intended to be used as a sole - source nutritional product because it contains no protein, fat, or vitamins and very low levels of minerals. |
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Bayer Contour Blood Glucose, 50 Test Strips by Ascensia Bayer HealthCare LLC does not warrant use of the Ascensia CONTOUR Blood Glucose Meter with any strip other than Ascensia CONTOUR Blood Glucose Test Strips. For complete warranty information, refer to User Guide. For in vitro diagnostic use. Before using this product, read the package insert. Store between temperature 59 -86° Fahrenheit and out of direct sunlight. Do not use after expiration date. For sale in U.S.A. only. Reagents:*6% w/w FAD glucose dehydrogenase(Aspergillus SP, 2.0 U/test strip) *56% w/w potassium ferricyanide *38% w/w nonreactive ingredients. For questions or comments, or help with reimbursement, call: 1-800-348-8100, or www.bayerdiabetes.com. Bayer HealthCare LLC is dedicated to providing the highest quality products and services to our customers. |
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Caullet Glucose Syrup - 2.2 lb by CAULLET Liquid sugar derived from corn, most often used in sorbet formulations and candy making. |
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The New Glucose Revolution: The Authoritative Guide to the Glycemic Index - the Dietary Solution for Lifelong Health by Jennie Brand-Miller (Author), Thomas M.S. Wolever (Author), Kaye Foster-Powell (Author), Stephen Colagiuri (Author) The New York Times bestseller, by the world's leading authorities on the glycemic index, now completely revised and updated: More useful and relevant than ever, The New Glucose Revolution is the definitive introduction to and an essential source of new information for everyone seeking to establish a way of eating for lifelong health, no matter what your current age, weight, or medical or physical condition. Widely recognized as the most significant dietary finding of the last twenty-five years, the glycemic index (GI)—an easy-to-understand measure of how foods affect blood glucose levels—shows how and why eating low-GI foods has major health benefits for everybody, every day, at every meal. This all-new third edition includes: ? The latest scientific findings on the GI and the myriad... |
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