Science Current Events | Science News | Brightsurf.com
 
Email a Friend Send to a friend
Printer Friendly Print Estrogen curbs appetite in same way as the hormone leptin

Estrogen curbs appetite in same way as the hormone leptin

January 04, 2007

Estrogen regulates the brain's energy metabolism in the same way as the hormone leptin, leading the way to a viable approach to tackling obesity in people resistant to leptin, researchers at Yale School of Medicine report in the December 31 online issue of Nature Medicine.

"We found that estrogen suppresses appetite using the same pathways in the brain as the adipose hormone leptin," said lead author Tamas L. Horvath, chair and professor of Comparative Medicine and professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine.




Horvath and his team studied the regulation of obesity in mice with mutations in leptin or estrogen signaling. They analyzed the effect of estrogen on the ability of nerve cells to make new connections in the hypothalamus. They also measured the associated feeding behavior and energy expenditure of the animals.

According to their report, estrogen is a strong regulator of energy metabolism through the brain. They show that while the pathway of estrogen-induced intracellular signaling merges with that of leptin, estrogen's effect on feeding and obesity is independent from leptin or the leptin receptor.

"Impaired estrogen signaling in the brain may be the cause of metabolic changes during menopause," said Horvath. "Brain-selective mimics of estrogen could be a viable approach to tackle obesity in the case of leptin resistance."

In previous studies, Horvath and his team found that that estrogen induces synaptic plasticity in the hypothalamus, so they looked to see whether those alterations by estrogen were in line with the proposed shift in the activity of the hypothalamus.

In future studies, Horvath and his team will analyze brain-specific mimics of estrogen on metabolism, obesity in particular. "Brain-specific estrogen analogs would allow us to take advantage of estradiol's weight reducing effects without altering peripheral tissues such as the breast and ovaries," said Horvath.

Yale University



Related Estrogen Current Events and Estrogen News Articles Estrogen Current Events and Estrogen News RSS Estrogen Current Events and Estrogen News RSS
Heart and bone damage from low vitamin D tied to declines in sex hormones
Researchers at Johns Hopkins are reporting what is believed to be the first conclusive evidence in men that the long-term ill effects of vitamin D deficiency are amplified by lower levels of the key sex hormone estrogen, but not testosterone.

Fertility procedures need not delay breast cancer treatment for younger women
A new study published in the November issue of the Journal of the American College of Surgeons shows that breast cancer patients under 40 years old who undergo fertility preservation do not face a significant delay in the treatment of their disease when their care is coordinated in a timely fashion.

Coffee break: Compound brewing new research in colon, breast cancer
A compound in coffee has been found to be estrogenic in studies by Texas AgriLife Research scientists.

Mayo researchers find robotic repair for vaginal prolapse has significant benefits
New Mayo Clinic research has found that robotic surgery for vaginal prolapse dramatically reduces patient hospital stay and recovery time.

Estrogen therapy likely must be given soon after menopause to provide stroke protection
For estrogen replacement to provide stroke protection, it likely must be given soon after levels drop because of menopause or surgical removal of the ovaries, scientists report in the Journal of Neuroscience.

Oral contraceptives may benefit women with asthma
New research shows that during natural menstrual cycles, women with asthma who were not taking oral contraceptives (OC) had lower exhaled nitric oxide levels (eNO), a marker of airway inflammation associated with asthma, than women who were taking OC.

Study shows hormone replacement therapy decreases mortality in younger postmenopausal woman
Hormone replacement therapy (HRT) to treat menopausal estrogen deficiency has been in widespread use for over 60 years. Several observational studies over the years showed that HRT use by younger postmenopausal women was associated with a significant reduction in total mortality; available evidence supported the routine use of HRT to increase longevity in postmenopausal women.

Hormone mix could cut breast cancer risk and treat symptoms of menopause
The right combination of estrogen and a selective estrogen receptor modulator (SERM), which blocks the effects of estrogen in breast tissue, could relieve menopause symptoms and cut breast cancer risk.

Breast tenderness during hormone replacement therapy linked to elevated cancer risk
Women who developed new-onset breast tenderness after starting estrogen plus progestin hormone replacement therapy were at significantly higher risk for developing breast cancer than women on the combination therapy who didn't experience such tenderness, according to a new UCLA study.

Study finds no relationship between PCR rate and race in women with breast cancer
Locally advanced breast cancer patients who received the same class of neoadjuvant chemotherapy were found to have no evidence of disease at the time of their surgery, or achieved pathological complete response, at the same rate regardless of race, according to researchers at The University of Texas M. D. Anderson Cancer Center.
More Estrogen Current Events and Estrogen News Articles
Source Naturals Phyto-Estrogen Cream, 4 oz (113.4 g)

Source Naturals Phyto-Estrogen Cream, 4 oz (113.4 g)
by Source Naturals

Advanced liposomal delivery. Non-GMO soy. Phyto-Estrogen Cream offers some of the finest phytoestregens, renowned for use during menopause. Each ounce contains 60 mg of isoflavone phytoestrogens, along with 150 mg of pomegranate juice extract, and 100 mg of red clover extract. Micro-penetrating liposomes pass through skin layers more easily than non-liposomal creams.

Natural Estrogen with Pomegranate Extract, 60 caplets

Natural Estrogen with Pomegranate Extract, 60 caplets
by Life Extension

Natural Estrogen with Pomegranate Extract60 caplets Item Catalog Number: 712 In an attempt to provide aging women with the multiple health effects of the bodies’ estrogen without side effects, scientists have discovered plant extracts with estrogenic activity (phytoestrogens). Natural Estrogen with Pomegranate Extract is one answer to the concerns of maintaining healthy hormone function. A review of the published literature reveals some interesting findings about how plant-derived estrogens can provide safe and effective support for such menopausal symptoms as hot flashes. Derived from organically-grown fruit, the pomegranate extract in this formula has the same ratio of polyphenols found in the whole fruit and all the benefits one would get from the juice without the sugar, calories,...

Estrogen/Estriol (Bio-Identical) Fragrance Free Cream 2 oz. Pump Bottle

Estrogen/Estriol (Bio-Identical) Fragrance Free Cream 2 oz. Pump Bottle
by Radiant Laboratories - Made In USA

Paraben-Free and Unscented. Menopausal Hot Flashes? Night Sweats? Trouble Sleeping? Replenish Your Estrogen Naturally and Safely. Get your life back! Estriol Has Been Used in Europe for Years. Bio-identical Hormones Are Safe and Effective. Non Prescription Bio-identical Natural Estrogen (Estriol Usp) Not to Be Confused with Phyto-estrogens. Bio-identical Hormones Are Safe for Women Help Relieve Menopause Symptoms. Estriol is not a phyto estrogen. Don't confuse phyto estrogens with pure natural estriol USP. The natural estrogen, estriol USP, is made the same way natural progesterone USP is made. Sterol analogues found in many varieties of plants are combined with specific bacteria and the resulting hormone is bio identical in chemical structure to the hormone produced by the human body....

Estroven Maximum Strength - 98 Caplets

Estroven Maximum Strength - 98 Caplets
by Amerifit

Estroven Maximum Strength is clinically shown to reduce hot flashes and night sweats. It contains a higher level of the key black cohosh and soy isoflavones ingredients found in Estroven Regular Strength, plus additional vitamins and minerals for women's health.

Emerita Phytoestrogen Body Cream with Black Cohosh, 2-Ounce Tube

Emerita Phytoestrogen Body Cream with Black Cohosh, 2-Ounce Tube
by Emerita

Peri/Menopause support. Paraben-free. Who knew a little tube of cream could change the world? In 1978 we had a revolutionary idea: that there was not enough real choice when it came to peri / menopause. So we created Pro-Gest, Phytoestrogen Cream and Pers

Phyto-Estrogen 60 Capsules

Phyto-Estrogen 60 Capsules
by Gaia Herbs

Provides a Natural Hormonal Balance During the Onset of Menopause Rich Natural Source of Phytoestrogens Support for the Peri-Menopause and Menopausal Years

The Greatest Experiment Ever Performed on Women: Exploding the Estrogen Myth, Second Edition

The Greatest Experiment Ever Performed on Women: Exploding the Estrogen Myth, Second Edition
by Barbara Seaman (Author)

A Library Journal Best Consumer Health Book of 2003 and an American Library Association/Booklist Editor's Choice Book of 2003

"Barbara Seaman is the first prophet of the women's health movement and her prophecies are still coming true."-Gloria Steinem

"A wake-up call to women about unquestioningly accepting doctors' orders."-Booklist (starred review)

"Lively and impassioned . . . [Seaman] certainly makes her point."-Gina Kolata, The New York Times

With the ardent tone of a close friend, Barbara Seaman draws on forty years of journalistic research to expose the "menopause industry" and shows how estrogen therapy often causes more problems-including breast cancer, heart attack, and stroke-than it cures. The Greatest Experiment Ever Performed on Women tracks the...

Alternative Health & Herbs Remedies Female Estrogen W, progesterone, 1-Ounce Bottle

Alternative Health & Herbs Remedies Female Estrogen W, progesterone, 1-Ounce Bottle
by Alternative Health & Herbs Remedies

Alternative Health & Herbs Remedies Female Estrogen W, progesterone, promotes hormonal balance, effective for women who are experiencing menopause and it does not contain hormones.

Estroven Dietary Supplement Caplets for Menopause, 30-Count Boxes (Pack of 2)

Estroven Dietary Supplement Caplets for Menopause, 30-Count Boxes (Pack of 2)
by Estroven

Dietary Supplement with Soy and Other Plants Plus Vitamins B6, E & Calcium. Naturally helps support hormonal balance. Daily dose caplets. Naturally, safely and gently provides hormonal support before, during and after menopause - because physical and psyc

Remifemin Menopause Herbal Supplement, Estrogen Free, 120 Tablets

Remifemin Menopause Herbal Supplement, Estrogen Free, 120 Tablets
by Remifemin

Remifemin, the #1 OB/GYN recommended OTC menopausal therapy. Clinically shown to reduce menopausal symptoms including hot flashes, night sweats, mood swings, irritability, related occasional sleeplessness. Effectively used by over 1.5 million women.

© 2009 BrightSurf.com