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Microtubule protein interactions visualized en masse
January 16, 2007In a new study published online in the open access journal PLoS Biology, Philipp Niethammer, Eric Karsenti, and colleagues investigate the regulation of microtubule dynamics via application of their new method, called visual immunoprecipitation (VIP), which enables simultaneous visualization of multiple protein interactions in cell extracts.
When eukaryotic cells undergo cell division, a dramatic reorganization occurs during the transition from interphase to metaphase. The cell rounds up, chromosomes condense, the nuclear envelope breaks down, and microtubules (proteins that help maintain the cell's shape) become very short and dynamic before assembly of the mitotic spindle (the structure that pulls chromosomes apart). Although it is known that the CDK1 kinase induces this reorganization, the precise mechanisms that regulate such coordinated changes are not yet understood.
There are two known major regulators of microtubule dynamics: a stabilizer (XMAP215) and a destabilizer (XKCM1); a series of other molecules (EB1, APC, and CLIP 170) are also involved, although their roles in the global regulation of microtubule dynamic instability are not as clear. Using VIP, these researchers show that microtubules are stable during interphase because the destabilizer is inhibited by the other molecul es. During mitosis, however, the destabilizer is released, triggering the alteration of microtubule structure and dynamics. Thus, microtubule dynamics change in response to a dramatic switch in the interactions of a set of proteins.
Public Library of Science
Public Library of Science
Microtubule Current Events and Microtubule News RSSGerton Lab determines the composition of centromeric chromatin
The Stowers Institute's Gerton Lab has provided new evidence to clarify the structure of nucleosomes containing Cse4, a centromere-specific histone protein required for proper kinetochore function, which plays a critical role in the process of mitosis. The work, conducted in yeast cells, was published in the most recent issue of Molecular Cell.
Newly Discovered Mechanism in Cell Division has Implications for Understanding Aberrant Chromosome's Role in Cancer, According to Penn Study
"A biologist, a physicist, and a nanotechnologist walk into a ..." sounds like the start of a joke. Instead, it was the start of a collaboration that has helped to decipher a critical, but so far largely unstudied, phase of how cells divide.
Researchers identify new function for protein missing in Duchenne muscular dystrophy
Researchers at the University of Minnesota and National Institutes of Health have identified a new function for the protein missing in people with the most common and ultimately lethal form of childhood muscular dystrophy.
The downside of microtubule stability
Stalled microtubules might be responsible for some cases of the neurological disorder Charcot-Marie-Tooth (CMT) disease.
Tiny but toxic: MBL researchers discover a mechanism of neurodegeneration in Alzheimer's disease
Tiny, toxic protein particles severely disrupt neurotransmission and inhibit delivery of key proteins in Alzheimer's disease, two separate studies by Marine Biological Laboratory (MBL) researchers have found.
Motor proteins may be vehicles for drug delivery
Specialized motor proteins that transport cargo within cells could be turned into nanoscale machines for drug delivery, according to bioengineers.
Mechanism of Alzheimer's suggests combination therapy needed
Researchers at the University of Illinois at Chicago College of Medicine have discovered a mode of action for mysterious but diagnostic protein snarls found in the brains of Alzheimer's patients that suggests a one-two punch of therapy may be needed to combat the neurodegenerative disease.
Molecule tracking reveals mechanism of chromosome separation in dividing cells
University of Washington (UW) researchers are helping to write the operating manual for the nano-scale machine that separates chromosomes before cell division.
Structural polymorphism of 441-residue Tau at single residue resolution
Worldwide almost 30 million suffer from Alzheimer's disease, an irreversible, neurodegenerative condition that is eventually fatal.
Mayo Clinic: Brain disorder suggests common mechanism may underlie many neurodegenerative diseases
A Mayo Clinic-led international consortium has found a mechanism that may help explain Parkinson's and other neurological disorders.
More Microtubule Current Events and Microtubule News Articles
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The Role of Microtubules in Cell Biology, Neurobiology, and Oncology (Cancer Drug Discovery and Development) by Antonio Tito Fojo (Author), Antonio Tito Fojo (Editor) Microtubule Targets in Cancer Therapy presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available. Among the topics examined in this volume are compounds that interact with tubulin, mechanisms and regulation by microtubule-associated proteins and drugs, MAPs, the tubulin superfamily its isotopes, peptides and depsipeptides, and neurodegenerative diseases. |
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Nusap, a Novel Microtubule-Associated Protein (Map) Involved in Mitotic Spindle Organization (Acta Biomedica Lovaniensia, 286) by Tim Raemaekers (Author) |
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Microtubules, Part A, Volume 96 (Methods in Cell Biology) by Leslie Wilson (Editor), John J. Correia (Editor) There continues to be intense interest in the microtubule cytoskeleton, the assembly, structure and regulation of microtubules and the numerous motors and accessory proteins that control cell cycle, dynamics, organization and transport. The field continues to grow and explore new aspects of these issues driven immensely by developments in optical imaging and tracking techniques. This volume (complimented by the forthcoming companion volume by Cassimeris and Tran) brings together current research and protocols in the field of microtoublues in vitro and will serve as a valuable tool for cell biologists, biophysicists and pharmacologists who study the microtubule cyctoskeleton, as well as for researchers in the biomedical and biotechnology communities with interest in developing... | |
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Microtubule Organization in Fission Yeast - A Systems Biology Approach by Dietrich Foethke (Author) In almost any eucaryotic cell microtubules are essential for a great variety of processes, including the separation of sister chromatids during cell division, the spatial organization of organelles within the cytoplasm, directed intracellular transport via motor proteins, and morphogenesis. The structure of the microtubule network and the regulation of its dynamics are therefore of utmost importance for the cell. In this work, the fission yeast Schizosaccharomyces pombe is used as a model organism to investigate how microtubule dynamics is controlled at the poles of an interphase cell. Experiments are combined with computer simulations to unravel the complicated interplay of cell shape, microtubule mechanics and regulatory proteins which enable the cell to establish and maintain its... |
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Microtubules in microorganisms (Microbiology series) by M. Dekker (Publisher) | |
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Microtubules by Jeremy S. Hyams (Editor), Clive W. Lloyd (Editor) Reflecting significant advances in microtubule research during the past decade, a prominent group of contributors present reviews dealing with three central topics—the biochemistry and assembly of tubulin dimer; associated proteins and regulation of microtubule function; and microtubule organization and function in the cell. |
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Asymmetric Microtubule Pushing Forces in Nuclear Centering [A short communication from: Current Biology by R.R. Daga (Author), A. Yonetani (Author), F. Chang (Author) This digital document is a journal article from Current Biology, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Abstract: Dynamic properties of microtubules contribute to the establishment of spatial order within cells. In the fission yeast Schizosaccharomyces pombe, interphase cytoplasmic microtubules are organized into antiparallel bundles that attach to the nuclear envelope and are needed to position the nucleus at the geometric center of the cell [1, 2]. Here, we show that after the nucleus is displaced by cell centrifugation, these microtubule bundles efficiently push the nucleus back to the center. Asymmetry in microtubule number,... |
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Microtubule: Webster's Timeline History, 1967 - 2007 by Icon Group International (Author) Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Microtubule," including when used in literature (e.g. all authors that might have Microtubule in their name). As such, this book represents the largest compilation of timeline events associated with Microtubule when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the arts, social... |
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Microtubule Proteins by Jesus Avila (Author) This work focuses on the structural and functional description of the microtubule proteins. The objective of the authors is to establish a relationship between the structure of microtubule proteins and the functions in which these polymers are involved. This book covers topics which have been treated only in a preliminary manner in previous works, such as microtubule dynamics and microtubule poisons. Microtubules display a variety of cellular roles and are vital for the separation and correct distribution of chromosomes during cell division. They also play an important role in morphogenesis, intracellular transport, secretion, and motility. Microtubule Proteins is a concise, easy-to-read text which is particularly of interest to cell biologists, chemists, neurochemists, and graduate... |
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Dynamic Aspects of Microtubule Biology (Annals of the New York Academy of Sciences) by David Soifer (Editor) |
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