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Noninvasive magnetic resonance imaging may help predict who's at risk for a heart attack
January 29, 2007The study suggests that magnetic resonance imaging (MRI)—a highly sensitive technique that provides three-dimensional views of tissue at the molecular level—effectively measured macrophages or white blood cells, in the arterial walls of blood vessels. These detailed images allowed researchers not only to see macrophage activity, but also to determine whether the activity was unstable and likely to trigger a heart attack or stroke, explains senior study author Zahi A. Fayad, PhD, Director of the Eva and Morris Feld Cardiovascular Imaging Research Laboratory and a Professor of Radiology and Medicine (Cardiology) at The Mount Sinai Medical Center.
Dr. Fayad and his colleagues injected mice with a synthetic material that tracked down and attached itself to macrophages embedded in the arterial walls. Twenty-four hours after injection, MRI tests showed that measuring and assessing macrophages in the arterial walls yielded a 79 percent increase in detection compared with the initial baseline images taken the day before.
"Our study results clearly show that detecting and measuring macrophage levels using MRI could be an effective and non-invasive screening tool for what's becoming one of the leading public health threats worldwide," Dr. Fayad explains. "We have known that macrophages are red flags indicating inflammation in the blood vessels, and mounting evidence has cemented the causal relationship between inflammation and cardiovascular disease. Yet we lacked the technology to measure this inflammation at the molecular level and predict who was at risk. Now, the technology is here, and our findings demonstrate that this new approach in cardiovascular screening not only works, but works very well."
The next step is to test this new approach in larger animals before moving to human clinical trials. Dr. Fayad says it's possible this technique could become part of standard clinical practice in the next few years.
Atherosclerosis is the pathological cause behind cardiovascular, cerebrovascular, and peripheral arterial diseases. It is currently the leading cause of death in industrialized nations, and is estimated that in the next 15 years, cardiovascular diseases alone will be the leading cause of death worldwide.
The Mount Sinai Hospital / Mount Sinai School of Medicine
The next step is to test this new approach in larger animals before moving to human clinical trials. Dr. Fayad says it's possible this technique could become part of standard clinical practice in the next few years.
Atherosclerosis is the pathological cause behind cardiovascular, cerebrovascular, and peripheral arterial diseases. It is currently the leading cause of death in industrialized nations, and is estimated that in the next 15 years, cardiovascular diseases alone will be the leading cause of death worldwide.
The Mount Sinai Hospital / Mount Sinai School of Medicine
Magnetic Resonance Imaging Current Events and Magnetic Resonance Imaging News RSSUCSB physicists move 1 step closer to quantum computing
Physicists at UC Santa Barbara have made an important advance in electrically controlling quantum states of electrons, a step that could help in the development of quantum computing.
Fat collections linked to decreased heart function
Researchers from Boston University School of Medicine (BUSM) have shown that fat collection in different body locations, such as around the heart and the aorta and within the liver, are associated with certain decreased heart functions.
Neuroimaging provides insights into new treatment options for Alzheimer's disease
With about 35 million people around the world suffering from Alzheimer's disease (AD) by the year 2010 and an expectation that these numbers will double every twenty years with approximately 115 million cases by 2050, pressure on healthcare systems worldwide will be intense.
'Emotions increase or decrease pain': researchers
Getting a flu shot this fall? Canadians scientists have found that focusing on a pretty image could alleviate the sting of that vaccine.
New UAB Study Sheds Light on Brain's Response to Distress, Unexpected Events
In a new study, psychologists at the University of Alabama at Birmingham (UAB) are able to see in detail for the first time how various regions of the human brain respond when people experience an unexpected or traumatic event.
Psychiatric impact of torture could be amplified by head injury
Depression and other emotional symptoms in survivors of torture and other traumatic experiences may be exacerbated by the effects of head injuries, according to a study from the Harvard Program in Refugee Trauma (HPRT), based in the Massachusetts General Hospital (MGH) Department of Psychiatry.
New methods found useful for diagnosing myocarditis
Myocarditis is an important, and often unrecognized cause of dilated cardiomyopathy (DCM). Several new diagnostic methods, such as cardiac magnetic resonance imaging (MRI), are useful for diagnosing myocarditis, according to a study published in the November 2009 issue of Mayo Clinic Proceedings.
Mending meniscals in children, improving diagnosis and recovery
The meniscus is a rubber-like, crescent moon-shaped cartilage cushion that sits between the leg and thigh bone. Each knee has two menisci: one on the inside of the knee joint and one on the outside.
Precuneus region of human and monkey brain is divided into 4 distinct regions
A study published this week in PNAS provides a comprehensive comparative functional anatomy study in human and monkey brains which reveals highly similar brain networks preserved across evolution.
Experts unveil new CVD guidelines and position papers
Several new guidelines and position papers offering the most up to date information to ensure that clinicians practice evidence-based medicine were released at the Canadian Cardiovascular Congress 2009 this week.
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