Common parasitic infection leads to increased risk for HIV infectionJanuary 29, 2007A new study shows a significantly increased risk of HIV infection among women with a common sexually transmitted disease, trichomoniasis. Although studies have been undertaken in the past to show the link between sexually transmitted infections and susceptibility to HIV, the study published in the March 1 issue of The Journal of Infectious Diseases, now available online, is one of the first to demonstrate a statistically significant association between trichomoniasis and HIV infection. Trichomoniasis, caused by the parasite, Trichomonas vaginalis infects more than 170 million people worldwide each year. On its own, it usually does not cause serious complications. Some men may experience a mild burning sensation or discharge. Some women may have a frothy, strong-smelling yellow green discharge, and may feel discomfort during intercourse and urination, as well as itching of the genital area. Lower abdominal pain occurs in rare cases. The study, conducted by R. Scott McClelland, MD, MPH, and colleagues at the University of Washington in Seattle, the University of Nairobi, and the Coast Provincial General Hospital in Kenya, followed 1,335 HIV-seronegative women over the span of 11 years. Because infection with T. vaginalis is common, even a modest increase in vulnerability to HIV acquisition as a result could mean a substantial attributable risk for HIV infection overall. According to McClelland, "the modest increase in risk makes it important that studies are either very large or of long duration in order to demonstrate such an effect." Their results showed a 1.5-fold increased risk of HIV infection among women with trichomoniasis. "What this means is that a woman with trichomoniasis is at about fifty percent greater risk for acquiring HIV than a woman without trichomoniasis, after adjusting for other differences between the women such as differences in the rates of condom use, number of sex partners, etc." said McClelland. The study pointed to several reasons why vaginal trichomoniasis could possibly lead to an increased risk of HIV acquisition. Trichomoniasis can cause tiny areas of bleeding within mucous membranes that could provide a physical pathway for HIV infection. Also, the study noted, the T. vaginalis parasite has been shown to break down an enzyme that blocks HIV attachment to cells. The findings from this study provide support for prevention and treatment of sexually transmitted diseases such as trichomoniasis as important strategies for preventing HIV infection. As a next step, McClelland suggested that "comprehensive strategies for reducing vaginal infections and addressing potentially harmful intravaginal practices such as douching, washing, or placing traditional substances in the vagina should be developed and evaluated in clinical trials as possible female-controlled HIV prevention interventions." Infectious Diseases Society of America |
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| Related Trichomoniasis Current Events and Trichomoniasis News Articles 'Good bacteria' in women give clues for slowing HIV transmission Beneficial bacteria found in healthy women help to reduce the amount of vaginal HIV among HIV-infected women and make it more difficult for the virus to spread, boosting the possibility that "good bacteria" might someday be tapped in the fight against HIV. UCLA and NYU microbiologists crack genome of a parasite that causes a common STD Scientists at UCLA and NYU have deciphered the genome of the parasite causing trichomoniasis, and their research may lead to new approaches to improve the diagnosis and treatment of this common sexually transmitted disease. Scientists crack the genome of the parasite causing trichomoniasis Scientists have finally deciphered the genome of the parasite causing trichomoniasis, a feat that is already providing new approaches to improve the diagnosis and treatment of this sexually transmitted disease. TIGR researchers reveal tricks of common sexually transmitted infection It's the world's most common non-viral sexually transmitted infection. There are an estimated 8 million cases of trich - pronounced "trick" - a year in North America and 170 million cases worldwide. Scientists sequence genome of parasite responsible for common sexually transmitted infection Researchers have decoded the genetic makeup of the parasite that causes trichomoniasis, one of the most common sexually transmitted infections (STIs), revealing potential clues as to why the parasite has become increasingly drug resistant and suggesting possible pathways for new treatments, diagnostics and a potential vaccine strategy. More Trichomoniasis Current Events and Trichomoniasis News Articles |
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