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New approach could lower antibiotic requirements by 50 times
January 30, 2007Steven Hagens, previously at the University of Vienna, told Chemistry & Industry, the magazine of the SCI, that certain bacteriophages, a type of virus that infects bacteria, can boost the effectiveness of antibiotics gentamicin, gramacidin or tetracycline.
It is the phages' ability to channel through bacterial cell membranes that boosts antibiotic effectiveness. 'Pseudomonas bacteria for example are particularly multi-resistant to antibiotics because they have efflux pump mechanisms that enable them to throw out antibiotics. A pore in the cell wall would obviously cancel the efflux effect,' Hagens explains.
Pseudomonas bacteria cause pneumonia and are a common cause of hospital-acquired infections.
Experiments in mice revealed that 75% of those infected with a lethal dose of Pseudomonas survived if the antibiotic gentamicin was administered in the presence of bacteriophages. None survived without the phages (Microb. Drug Resist., 2006, 12 (3), 164).
The bacteriophage approach would also be particularly useful for treating cases of food poisoning, because the lower doses of antibiotic needed would not disrupt the friendly bacteria in the gut-a big problem with conventional antibiotic treatments.
'The prospect of using such treatments to prolong the life of existing agents and delay the onset of widespread resistance is to be welcomed,' said Jim Spencer a lecturer in microbial pathogenesis at the University of Bristol.
The overuse of antibiotics since the 1940s had slowly created a host of infections that are resistant to antibiotics. MRSA (Methicillin-resistant Staphylococcus aureus) for example is rapidly spreading through hospitals, affecting more than 8,000 people in the UK every year. MRSA infection can lead to septic shock and death.
Society of Chemical Industry
Experiments in mice revealed that 75% of those infected with a lethal dose of Pseudomonas survived if the antibiotic gentamicin was administered in the presence of bacteriophages. None survived without the phages (Microb. Drug Resist., 2006, 12 (3), 164).
The bacteriophage approach would also be particularly useful for treating cases of food poisoning, because the lower doses of antibiotic needed would not disrupt the friendly bacteria in the gut-a big problem with conventional antibiotic treatments.
'The prospect of using such treatments to prolong the life of existing agents and delay the onset of widespread resistance is to be welcomed,' said Jim Spencer a lecturer in microbial pathogenesis at the University of Bristol.
The overuse of antibiotics since the 1940s had slowly created a host of infections that are resistant to antibiotics. MRSA (Methicillin-resistant Staphylococcus aureus) for example is rapidly spreading through hospitals, affecting more than 8,000 people in the UK every year. MRSA infection can lead to septic shock and death.
Society of Chemical Industry
Antibiotic Current Events and Antibiotic News RSSAmid the flu epidemic, don't forget RSV in young children
Influenza, particularly H1N1, has understandably captured the attention of public health officials, the media and the public.
Multiple health concerns surface as winter, vitamin D deficiences arrive
A string of recent discoveries about the multiple health benefits of vitamin D has renewed interest in this multi-purpose nutrient, increased awareness of the huge numbers of people who are deficient in it, spurred research and even led to an appreciation of it as "nature's antibiotic."
New study finds MRSA on the rise in hospital outpatients
The community-associated strain of the deadly superbug MRSA-an infection-causing bacteria resistant to most common antibiotics-poses a far greater health threat than previously known and is making its way into hospitals, according to a study in the December issue of Emerging Infectious Diseases.
A Second Skin
Despite advances in treatment regimens and the best efforts of nurses and doctors, about 70% of all people with severe burns die from related infections.
Study reveals why certain drug combinations backfire
Combination drug therapy has become a staple for treating many infections. For instance, doctors treat extensively drug resistant forms of tuberculosis with one drug that breaks down the pathogen's protective barriers and opens the door for another to deliver the deathblow.
Exposure to several common infections over time may be associated with risk of stroke
Cumulative exposure to five common infection-causing pathogens may be associated with an increased risk of stroke, according to a report posted online today that will appear in the January 2010 print issue of Archives of Neurology, one of the JAMA/Archives journals.
New imagining technique could lead to better antibiotics and cancer drugs
A recently devised method of imaging the chemical communication and warfare between microorganisms could lead to new antibiotics, antifungal, antiviral and anti-cancer drugs, said a Texas AgriLife Research scientist.
U.S. and European Experts Applaud Creation of New Transatlantic Task Force on Global Antibiotic Resistance Threat
Experts on both sides of the Atlantic applaud President Barack Obama and Swedish Prime Minister Fredrik Reinfeldt, representing the European Union (EU) Presidency, for establishing a transatlantic task force to address antibiotic resistance, an urgent and growing problem that threatens patient safety and public health worldwide.
Does prostate-specific antigen velocity help in early detection prostate cancer?
The November issue of European Urology, the official journal of the European Association of Urology, features an article focussing on prostate specific antigen (PSA) velocity and early cancer detection. It has been suggested that changes in PSA over time aid prostate cancer detection.
Researchers identify drug candidate for treating spinal muscular atrophy
A chemical cousin of the common antibiotic tetracycline might be useful in treating spinal muscular atrophy (SMA), a currently incurable disease that is the leading genetic cause of death in infants.
More Antibiotic Current Events and Antibiotic News Articles
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Antibiotics Pocketcard 2009 by H. Hof (Author) Antibiotics pocketcard provides an initial choice of antimicrobial therapy for most common infections. These empirical therapies cover more than 90% of everyday scenarios. The reverse side of this durable plastic card shows a table of antimicrobial spectra for the most important antibiotics. **2009 edition, completely updated! **Initial choice of antimicrobials for: CNS, heart, blood, gastrointestinal tract, bones/joints, urogenital tract, eye, ENT, skin/soft tissue diseases, fever of unknown origin. **Antimicrobial agents against selected bacteria, e.g. streptococci, staphylococci. |
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First Aid Only Triple Antibiotic Ointment Pack, 0.5 Gram, 25-Count Boxes (Pack of 3) by First Aid Only Use this triple antibiotic ointment pack to treat all kinds of minor cuts, burns and abrasions. Helps prevent infection while it promotes healing. May be applied 2 to 3 times daily as the condition indicates. Active ingredients: neomycin and polymyxin B sulfates and bacitracin zinc ointment USP. |
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Fish Mox (Amoxicillin 250 mg) - 100 Caps by THOMAS LABS Fish-Mox exerts a bactericidal action on gram positive and some gram negative bacteria. Useful for control of some common bacterial diseases of fish including aeromonas and pseudomonas genera and mysobacterial group (gill diseases, chondrococcus). Add contents of one capsule (250 mg) into aquarium for each 10 gallons of water to be treated. Repeat in 24 hours. It is suggested that a partial water change be made between treatments. While duration of treatment depends on type and severity of infection, it is recommended that extended medication baths continue for a minimum of 5 days & for not more than 10 days. Discontinue treatment if no improvement is noted within 5 days. To remove harmless yellow color, change 20% of water and use charcoal filter until clear. |
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Antibiotics Simplified by Jason Gallagher (Author) Antibiotics Simplified is a succinct guide designed to bridge knowledge gained in basic sciences courses with clinical practice in infectious diseases. Introductory chapters explain the rationale behind the treatment of infectious diseases, describe a system for selecting antimicrobial agents and briefly review basic microbiology. Later chapters present relevant characteristics of drug classes, emphasizing clinical "pearls" for individual agents, and also include content on antifungals. The concise nature of the text allows for emphasis on key points, allowing readers to extract the most important characteristics of anti-infective drugs from the larger mass of material that they learn from detailed pharmacology textbooks. This is an ideal handbook for students as well as practicing... |
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Antibiotic Essentials 2009 by Burke Cunha MD (Author) Antibiotic Essentials is a concise, practical, and authoritative guide to the treatment and prevention of infectious diseases commonly encountered in adults. It covers 542 clinical infectious disease syndromes, HIV infection, 134 detailed drug summaries, pediatric infectious diseases, and a chest x-ray atlas. Topics include: Empiric Therapy Based on Clinical Syndrome; Initial Therapy Based on Isolates; Pending Susceptibility Testing; HIV Infection; Fungi, Parasites, Unusual Organisms; Antibiotic Prophylaxis and Immunizations; Drug Summaries |
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First Aid Only Triple Antibiotic Ointment Pack, 0.5 Gram, 10-Count Boxes (Pack of 10) by First Aid Only Use this triple antibiotic ointment pack to treat all kinds of minor cuts, burns and abrasions. Helps prevent infection while it promotes healing. May be applied 2 to 3 times daily as the condition indicates. Active ingredients: neomycin and polymyxin B sulfates and bacitracin zinc ointment USP. |
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2009 Emra Antibiotic Guide by Brian J. Levine MD (Editor) The 2009 EMRA Antibiotic Guide, 13th edition, is designed to be a quick reference guide to antibiotic use in the emergency department. The contents are organized alphabetically by organ system, followed by sections on "Special Topics" to make reference quick and easy for a particular disease process. As requested by popular demand from loyal users, each organ system and special topic section is color coded for quick reference. EMRA Members receive a complimentary copy of each new version of the Antibiotic Guide as one of the many benefits of membership. To learn more, please visit www.emra.org. |
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Fish Flex Cephalexin - 250 mg 100 capsules by THOMAS LABS Fish-Flex is for use in aquariums for treatment of bacterial activity. Add contents of one capsule (250 mg) into aquarium for each 10 gallons of water to be treated. Repeat in 24 hours. It is suggested that a partial water change be made between treatments. While duration of treatment depends on type and severity of infection, it is recommended that extended medication baths continue for a minimum of 5 days & for not more than 10 days. Discontinue treatment if no improvement is noted within 5 days. |
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Antibiotic Basics for Clinicians: Choosing the Right Antibacterial Agent (Point (Lippincott Williams & Wilkins)) by Alan R Hauser (Author) Designed for quick, easy comprehension, this handbook reference will assist medical students in understanding the rationale behind antibiotic selection for common bacterial pathogens and infectious disease presentations. By supplying the rationale for choosing antibiotics, the book reduces the amount of memorization necessary for proper antibiotic prescribing. The book is heavily illustrated with two-color figures and includes fact-anecdotes, interesting ancillary information, mnemonics, and questions to test understanding. Appendices include dosing in adults and children; antibacterial agents in pregnancy; generic and trade names of commonly used antibacterial agents; and treatment of infections caused by bacterial agents of bioterrorism. |
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Neosporin Plus Pain Relief First Aid Antibiotic/Pain Relieving Ointment, Maximum Strength, 1-Ounce Tubes (Pack of 3) by Neosporin Bacitracin Zinc-Neomycin Sulfate-Polymyxin B Sulfate-Pramoxine HCI. Maximum Strength Pain Relief. Soothes painful cuts, scrapes and burns while preventing infection. Keep In: Kitchen; Bathroom; Workshop; Travel Bag. Soothes the pain of burns; Suitable for |
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