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3-D ultrasound identifies women at risk for impending preterm birth
February 09, 2007To help physicians non-invasively identify women at risk for preterm birth, 3-D ultrasound was used to measure the size of fetal adrenal glands, according to an abstract presented by Yale School of Medicine researchers at the Society for Maternal-Fetal Medicine Conference February 8 in San Francisco.
Preterm birth is a major public health problem with lasting repercussions on families and society. The authors found that the ultrasound measurements could identify a preterm risk of delivery within five days of the measurement.
"Our results suggest that examining the fetal adrenal gland at the time a woman is evaluated for symptoms of preterm labor, may have major beneficial clinical implications," said first author Ozhan Turan, postdoctoral fellow in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine. Turan conducted the study with senior author Catalin Buhimschi, M.D., director of Perinatal Research at Yale Ob/Gyn.
The authors said that understanding the time when a marker becomes positive in relationship to preterm birth is essential for a test with high diagnostic accuracy. "The high accuracy, sensitivity and specificity of the adrenal gland volume in predicting preterm birth within five days from the time of examination proves that 3-dimensional ultrasound evaluation of the fetal adrenal gland has the desired test characteristics to define a population at risk," they said.
The current study creates the basis for further prospective studies to confirm that 3-dimensional ultrasound assessment of the fetal adrenal gland volume can assist clinicians with devising better therapeutic and preventive interventions for preterm birth.
Yale University
The authors said that understanding the time when a marker becomes positive in relationship to preterm birth is essential for a test with high diagnostic accuracy. "The high accuracy, sensitivity and specificity of the adrenal gland volume in predicting preterm birth within five days from the time of examination proves that 3-dimensional ultrasound evaluation of the fetal adrenal gland has the desired test characteristics to define a population at risk," they said.
The current study creates the basis for further prospective studies to confirm that 3-dimensional ultrasound assessment of the fetal adrenal gland volume can assist clinicians with devising better therapeutic and preventive interventions for preterm birth.
Yale University
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Neurodevelopmental Outcomes of Preterm Birth: From Childhood to Adult Life by Chiara Nosarti (Editor), Robin M. Murray (Editor), Maureen Hack (Editor) The improved survival of very preterm and very low birth weight infants in recent decades has been associated with an increase in the prevalence of physical and neurodevelopmental problems. Attention is increasingly being focused on the quality of life of survivors, who are at greater risk of brain damage and consequent neurological disorders, and neuropsychological and behavioural impairments. In this volume, leading experts present a comprehensive and up-to-date perspective on research in various aspects of the long-term consequences of very preterm birth. As well as extending existing knowledge of the neurodevelopmental sequelae following very preterm birth, a shared aim of this burgeoning body of research is to identify the mechanisms underlying variations in outcome, and thus... |
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Preterm Birth: Mechanisms, Mediators, Prediction, Prevention & Interventions (Series in Maternal Fetal Medic) by Felice Petraglia (Editor), Jerome F. Strauss III (Editor), Steven G. Gabbe (Editor), Gerson Weiss (Editor) Preterm delivery is probably the most important problem in obstetrics, and a major public health concern. Recent developments - such as the preventive use of progesterone, and new data on possible mechanisms of initiation of parturition – have placed the topic at the forefront of the interests and preoccupation of many in maternal-fetal medicine and obstetrics. Recent studies have found that preterm deliveries have increased even amongst low risk women. Also shown is that assisted conceptions, multiple pregnancies and elective deliveries are associated with early birth. The impact on society is considerable. Preterm birth can also have considerable impact on long-term health, including severe mental or physical disability. With all this being currently debated,... |
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