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Continuous infusion of hydrocortisone reduces hyperglyaemia in patients with septic shock
February 16, 2007Changing how critically ill patients are treated with hydrocortisone could reduce hyperglycemia. The results of a randomized controlled clinical trial, published today in the journal Critical Care, lead researchers to recommend using continuous infusion of low-dose hydrocortisone in patients with sepsis, rather than bolus injections. The study shows that continuous infusion of low-dose hydrocortisone minimizes hyperglycaemic episodes, serious adverse events that can lead to insulin dependency. The researchers also found that continuous infusion reduced nurses' workload.
Low dose hydrocortisone treatment is widely used as a treatment for patients suffering from septic shock. However, hydrocortisone stimulates glucose production in the liver and other tissues and may induce high blood glucose levels, or hyperglycaemia. Preventing hyperglycaemia has previously been shown to improve the survival of critically ill patients.
Pekka Loisa of the Päijät-Häme Hospital in Finland, and colleagues from hospitals throughout Finland carried out the trial involving 48 patients in four intensive care units (ICUs) between July 2005 and April 2006. One group of 24 patients received the hydrocortisone treatment by continuous infusion of 200mg/day. The bolus therapy group of 24 patients received the same overall dose, but the hydrocortisone was administered intravenously in 50mg doses every six hours. Loisa et al. compared blood glucose levels, insulin requirements and the nursing workload for the two groups. Hydrocortisone treatment lasted five days in both groups.
Loisa et al. found that the mean blood glucose levels were similar in both groups, but the number of hyperglycaemic episodes was higher in the group receiving bolus therapy. For patients undergoing bolus therapy, the insulin infusion rate had to be changed more often to maintain normal blood glucose levels, adding to nurses' workload. The researchers stress that normal blood glucose levels can be achieved successfully using both methods. However, strict normoglycemia is more easily achieved with continuous hydrocortisone infusion.
BioMed Central
Loisa et al. found that the mean blood glucose levels were similar in both groups, but the number of hyperglycaemic episodes was higher in the group receiving bolus therapy. For patients undergoing bolus therapy, the insulin infusion rate had to be changed more often to maintain normal blood glucose levels, adding to nurses' workload. The researchers stress that normal blood glucose levels can be achieved successfully using both methods. However, strict normoglycemia is more easily achieved with continuous hydrocortisone infusion.
BioMed Central
Steroid Treatment Offers No Benefit In Preemies, Hopkins Children's Study Suggests
Results of a multicenter study led by Johns Hopkins Children's Center challenge the longstanding practice of treating premature babies with hydrocortisone, a steroid believed to fight inflammation and prevent lung disease.
MSU researchers make new discoveries on what does and doesn't affect immune system
Scientists know that a number of factors can affect the body's immune system: poor diet, certain steroids, chronic stress. Now researchers at Michigan State University have discovered that an appetite-controlling hormone also affects the immune system, while natural versions of certain steroids do not.
Use of hydrocortisone reduces incidence of atrial fibrillation after cardiac surgery
Patients who receive corticosteroids after cardiac surgery have a significantly lower risk of atrial fibrillation in the days following the surgery.
Hydrocortisone supplementation improves ventilator weaning
ntensive care unit physicians can increase the success of mechanical ventilation weaning and shorten the weaning period by identifying critically ill patients who have adrenal insufficiency and treating them with the hormone hydrocortisone (cortisol).
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Member's Mark® Hydrocortisone Cream 1% - 4/2oz by Members Mark Overview Relieves itches and rashes due to insect bites, eczema, psoriasis, poison oak and ivy. SpecificationsValue pack Compare to Cortaid Four - two ounce tubes Laboratory tested - Quality assured Drug Facts |
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Aveeno 1% Hydrocortisone Anti-Itch Cream, Maximum Strength, 1-Ounce Tubes (Pack of 4) by Aveeno Aveeno 1 percent Hydrocortisone Anti-Itch Cream is enriched with Aloe and Vitamin E and dermatologist recommended. Effective itch relief with skin-soothing natural colloidal oatmeal. Effective Relief of Itching Due to Inflammation and Rashes Due to: Eczem |
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Cortizone 10 Hydrocortisone Anti-Itch Creme, Intense Healing 2 oz (57 g) by Chattem, Inc Helps Heal Itch Fast Clinically prove to moisturize in 24 hours. Cont |
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Itch-X Fast-Acting Anti-Itch Moisturizing Hydrocortisone Lotion, 3-Ounce Bottle (Pack of 2) by Itch-x Stop scratching irritated, dry itchy skin with Itch-X lotion. Itch-X Lotion attacks the itch and moisturizes the affected area. Itch-X lotion starts working on contact for the temporary relief from itching associated with minor skin irritations, inflammation, psoriasis, eczema and rashes. |
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Kirkland Signature Maximum Strength Hydrocortisone Cream 1% with Aloe (4 X 2 ... by Kirkland |
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Hydrocortisone 1 % Max Ointment (GenericCortaid) 1 oz by E. FOUGERA SKU NUMBER: 213561The Mininimum EXP date on product:1Year.TITLE DESCRIPTION: Hydrocortisone 1 % Maximum Strength Ointment --- 1 Oz ( Generic Cortaid Maximum Strength 1% Hydrocortisone Ointment ) 50 % OffMANUFACTURER:PREFFERED PLUS PRODUCTS. PRODUCT DESCRIPTION:Temporarily relieves itching associated with minor skin irritation, inflammation and rashes due to: Eczema, Psoriasis, Seborrheic Dermatitis, Insect Bites, Detergents, Poison Ivy/Oak/Sumac, Soaps, Cosmetics, Jewelry, and external feminine and anal itching. Other uses of this product: ask a doctor. INGREDIENTS:Active Ingredient:Per container: Hydrocortisone Acetate (equivalent to hydrocortison 1.0%). Inactive Ingredients :Butylparaben, Cholestrol, Methylparaben, Microcrystalline Wax, Mineral Oil, White Petrolatum. SUGGESTED USE:apply... |
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Zymox Otic Pet Ear Treatment with Hydrocortisone, 1-1/4-Ounce by Pet King Brands ZYMOX Otic is used in dogs and cats for the treatment of acute and chronic inflammation of the external ear caused by bacterial, viral and yeast infections. Treat once a day for 7 days for acute infection and once a day for 14 days for chronic infection. Do not use in conjunction with other topical ear medications or cleaners. |
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Aveeno 1% Hydrocortisone Anti-Itch Cream, Maximum Strength, 1-Ounce Tubes (Pack of 4) by Aveeno Aveeno 1 percent Hydrocortisone Anti-Itch Cream is enriched with Aloe and Vitamin E and dermatologist recommended. Effective itch relief with skin-soothing natural colloidal oatmeal. Effective Relief of Itching Due to Inflammation and Rashes Due to: Eczema; Psoriasis; Seborrheic dermatitis; Poison ivy, oak, sumac; Insect bites; Detergents; Soaps; Cosmetics; Jewelry. The Aveeno brand has been dermatologist recommended for over 50 years. |
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