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Mouse stem cell line advance suggests potential for IVF-incompetent eggs
February 20, 2007Researchers have found that mouse oocytes that fail to become fertilized during in vitro fertilization are nevertheless often capable of succeeding as "cytoplasmic donors" during a subsequent cloning step using so-called nuclear transfer. Although the implications for human eggs are not yet clear, the findings are of interest because of the ethical and practical concerns surrounding the need for fresh human oocytes for similar nuclear-transfer procedures using human cells. The findings, reported by Teruhiko Wakayama, Sayaka Wakayama, and colleagues at RIKEN Kobe in Japan, appear in the February 20th issue of the journal Current Biology, published by Cell Press.
Human IVF is now routinely practiced in fertility clinics, but a proportion of oocytes fail to become fertilized in these procedures. In the new work, researchers examined the ability of day-old mouse oocytes that fail to become fertilized in vitro—"aged, fertilization-failure" (or AFF) oocytes—to succeed in a standard cloning procedure in which the oocyte's nucleus is removed and replaced by the nucleus of a somatic cell. Although this nuclear-transfer procedure showed a lower rate of success in the very first stages of cloning compared to nuclear transfer with fresh oocytes, the early (morulae- or blastocyst-stage) mouse embryos derived from nuclear transfer using AFF oocytes showed similar rates of success in giving rise to embryonic stem cell lines.
Cell Press
Oocytes Current Events and Oocytes News RSSStem cell research: From molecular physiology to therapeutic applications
Stem cell research promises remedies to many devastating diseases that are currently incurable, ranging from diabetes and Parkinson's disease to paralysis.
Who goes abroad for fertility treatment and why?
A substantial number of European patients travel to other countries for fertility treatment, both because they think that they will receive better quality care abroad and in order to undergo procedures that are banned in their home country.
Reduced ovarian reserve associated with increased risk of trisomic pregnancy
Women who have a diminished number of eggs in their ovaries, either because they are older or for some other reason such as ovarian surgery, may be more at risk of a trisomic pregnancy than women with an ovarian reserve within the normal, fertile range.
Universitat Autonoma de Barcelona researchers first to clone mice in Spain
Researchers at the Department of Cell Biology, Physiology and Immunology at Universitat Autònoma de Barcelona (UAB) are the first to have cloned mice in Spain. Cloe, Cleo and Clona are three female brown-coloured mice and were born respectively on 12 May, 3 June and 10 June.
2 studies: The first finds twins born after fertility treatment have a higher risk of problems
Twins born as a result of assisted reproductive technology (ART) are more likely to be admitted to neonatal intensive care and to be hospitalised in their first three years of life than spontaneously conceived twins
Animal eggs not suitable substitutes to produce stem cells
Since the cloning of Dolly the Sheep over a decade ago, somatic cell nuclear transfer (SCNT) has been considered a promising way to generate human, patient-specific stem cells for therapeutic applications.
CSHL scientists discover a new way in which epigenetic information is inherited
Hereditary information flows from parents to offspring not just through DNA but also through the millions of proteins and other molecules that cling to it.
Rong Li Lab probes mechanism of asymmetry in meiotic cell division
The Stowers Institute's Rong Li Lab has characterized a mechanism that allows for asymmetrical cell division during meiosis in oocytes. By tracking chromosome movement in live mouse oocytes, the team discovered that chromosomes can recruit to their vicinity a protein called formin-2.
What to do with leftover embryos in fertility clinics?
The majority of infertility patients are in favor of using left-over embryos for stem cell research and would also support selling left-over embryos to other couples, according to a recent survey.
Cryopreservation techniques bring hopes for women cancer victims and endangered species
Emerging cryopreservation techniques are increasing hope of restoring fertility for women after diseases such as ovarian cancer that lead to destruction of reproductive tissue.
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