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Mouse stem cell line advance suggests potential for IVF-incompetent eggs
February 20, 2007Researchers have found that mouse oocytes that fail to become fertilized during in vitro fertilization are nevertheless often capable of succeeding as "cytoplasmic donors" during a subsequent cloning step using so-called nuclear transfer. Although the implications for human eggs are not yet clear, the findings are of interest because of the ethical and practical concerns surrounding the need for fresh human oocytes for similar nuclear-transfer procedures using human cells. The findings, reported by Teruhiko Wakayama, Sayaka Wakayama, and colleagues at RIKEN Kobe in Japan, appear in the February 20th issue of the journal Current Biology, published by Cell Press.
Human IVF is now routinely practiced in fertility clinics, but a proportion of oocytes fail to become fertilized in these procedures. In the new work, researchers examined the ability of day-old mouse oocytes that fail to become fertilized in vitro—"aged, fertilization-failure" (or AFF) oocytes—to succeed in a standard cloning procedure in which the oocyte's nucleus is removed and replaced by the nucleus of a somatic cell. Although this nuclear-transfer procedure showed a lower rate of success in the very first stages of cloning compared to nuclear transfer with fresh oocytes, the early (morulae- or blastocyst-stage) mouse embryos derived from nuclear transfer using AFF oocytes showed similar rates of success in giving rise to embryonic stem cell lines.
Cell Press
Oocytes Current Events and Oocytes News RSSFertility procedures need not delay breast cancer treatment for younger women
A new study published in the November issue of the Journal of the American College of Surgeons shows that breast cancer patients under 40 years old who undergo fertility preservation do not face a significant delay in the treatment of their disease when their care is coordinated in a timely fashion.
Stem cell research: From molecular physiology to therapeutic applications
Stem cell research promises remedies to many devastating diseases that are currently incurable, ranging from diabetes and Parkinson's disease to paralysis.
Who goes abroad for fertility treatment and why?
A substantial number of European patients travel to other countries for fertility treatment, both because they think that they will receive better quality care abroad and in order to undergo procedures that are banned in their home country.
Reduced ovarian reserve associated with increased risk of trisomic pregnancy
Women who have a diminished number of eggs in their ovaries, either because they are older or for some other reason such as ovarian surgery, may be more at risk of a trisomic pregnancy than women with an ovarian reserve within the normal, fertile range.
Universitat Autonoma de Barcelona researchers first to clone mice in Spain
Researchers at the Department of Cell Biology, Physiology and Immunology at Universitat Autònoma de Barcelona (UAB) are the first to have cloned mice in Spain. Cloe, Cleo and Clona are three female brown-coloured mice and were born respectively on 12 May, 3 June and 10 June.
2 studies: The first finds twins born after fertility treatment have a higher risk of problems
Twins born as a result of assisted reproductive technology (ART) are more likely to be admitted to neonatal intensive care and to be hospitalised in their first three years of life than spontaneously conceived twins
Animal eggs not suitable substitutes to produce stem cells
Since the cloning of Dolly the Sheep over a decade ago, somatic cell nuclear transfer (SCNT) has been considered a promising way to generate human, patient-specific stem cells for therapeutic applications.
CSHL scientists discover a new way in which epigenetic information is inherited
Hereditary information flows from parents to offspring not just through DNA but also through the millions of proteins and other molecules that cling to it.
Rong Li Lab probes mechanism of asymmetry in meiotic cell division
The Stowers Institute's Rong Li Lab has characterized a mechanism that allows for asymmetrical cell division during meiosis in oocytes. By tracking chromosome movement in live mouse oocytes, the team discovered that chromosomes can recruit to their vicinity a protein called formin-2.
What to do with leftover embryos in fertility clinics?
The majority of infertility patients are in favor of using left-over embryos for stem cell research and would also support selling left-over embryos to other couples, according to a recent survey.
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The Fish Oocyte: From Basic Studies to Biotechnological Applications by Patrick J. Babin (Editor), Joan Cerdà (Editor), Esther Lubzens (Editor) This book addresses the growing needs in deciphering the biological processes associated with fish reproduction, in view of the growth of aquaculture and the dwindling natural stocks of commercially important fish. It presents a comprehensive overview on egg production in fish, from the standpoint of the oocyte. With this view in mind, the book includes chapters on oocyte development (oogenesis), hormonal regulation and hormone receptors, formation of the egg envelopes, growth, accumulation of nutrients and maternal transcripts, maturation, hydration, ovulation and fertilization. A special emphasis is placed on using state-of-the-art tools including electron microscopy for discerning the ultra-structure of the follicle and genomic/proteomic tools to fully understand biological basis of... |
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Anopholes Mosquito Oocytes Photographic Poster Print, 32x24 by AllPosters.com AllPosters.com is the world's #1 seller of posters, prints, photographs, specialty products and framed art. We're dedicated to bringing our customers the best selection of high quality wall décor that is perfect for their home or office. Browse our catalog of over 300,000 items that include entertainment and specialty posters, decorative prints, and art reproductions. Whether you're looking for your favorite movie or music poster, a framed Monet reproduction, or a print of the Eiffel Tower you will find it at AllPosters.com. Visit our Amazon store today at www.amazon.com/allposters to find Special Offers and search by subject category or artist. AllPosters.com provides unmatched service with a 100% satisfaction guarantee. We ship internationally to over 80 countries. Decorate your... |
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Gametes - The Oocyte (Cambridge Reviews in Human Reproduction) by J. G. Grudzinskas (Editor), J. L. Yovich (Editor) This volume, and its companion volume on the spermatozoon, provide a wide-ranging analysis of the gametes and their reproductive role in humans. The authors give a detailed account of the oocyte that includes particularly helpful information on female infertility and its treatment. The book starts with an evolutionary perspective before focusing on the molecular and cellular biology of the oocyte and its structure and function. The development and maturation of the oocyte is also fully described, including an account of the endocrine and paracrine regulation of ovarian function. Practical issues such as oocyte storage and ovarian stimulation are also fully covered. The volume will be an essential source of information for all clinicians and scientists with an interest in human... |
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Biology and Pathology of the Oocyte: Its Role in Fertility and Reproductive Medicine by Alan O. Trounson (Editor), Roger G. Gosden (Editor) The human oocyte, or egg, is the rarest and most rapidly aging cell in the body, and is essential for fertility. This book is about the development and pathology of the oocyte, and includes information on new technologies to manipulate, enhance, and control fertility. Leading world experts contribute essays on the basic and applied science of the egg, its clinical manipulation, and its pivotal role in reproductive medicine and biology. |
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Anopholes Mosquito Oocytes Photographic Poster Print, 40x30 by Art.com Art.com is the world's largest retailer of art prints, posters, photographs, and framed artwork. With our huge selection of over 400,000 prints, you'll easily find the perfect piece for your home, office, or classroom. Our art is printed on quality paper. When you order framed artwork, the piece is built by our team of in-house professionals. Visit our Amazon store today at www.amazon.com/artdotcom to find Special Offers and search for products based on 'Artist Name' and 'Subject Categories' such as Movie, Music, Vintage, TV, Children, Travel, Kitchen, Museum Art, Animals, Floral, Motivational, and Sports. Art.com is dedicated to providing you with high quality products and service by offering you 100% satisfaction guaranteed. We ship internationally to over 80 countries. Decorate your... |
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Human Fertility and Reproduction: The Oocyte, the Embryo, and the Uterus (Annals of the New York Academy of Sciences) by Carlo Bulletti (Editor), Dominique de Ziegler (Editor), Seth Guller (Editor), Mortimer Levitz (Editor) This unique volume provides a comprehensive overview of basic research and clinical applications of reproductive biology, with an emphasis on new developments in the field. The objective is to provide information from basic research that will lead to a clearerunderstanding of the intricate mechanisms underlying human reproduction--particularlyuterine function--and their roles in fertility and sterility. Recent advances in the clinicaltreatment of human infertility also are presented. |
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Principles of Oocyte and Embryo Donation by Mark V. Sauer (Author), M.V. Sauer (Author) Principles of Oocyte and Embryo Donation is the definitive textbook on the medical, surgical, legal, and ethical aspects of establishing and maintaining an office-based egg donation program. The editor has assembled an international list of authors with known expertise in this rapidly expanding field. Comphrensive, yet practical, chapters include: * indications and success rates * screening and demographics of recipients and donors * preparation of the endometrium * synchronization of cycles * obstetrical outcomes * risks and complications * gestational carriers * consents and contracts * ethics The clinical steps and procedures are clearly outlined in photographs and line drawings. This book is a must-have reference for all health care providers of ART programs, reproductive ... | |
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Anopholes Mosquito Oocytes Photographic Poster Print, 16x12 by AllPosters.com AllPosters.com is the world's #1 seller of posters, prints, photographs, specialty products and framed art. We're dedicated to bringing our customers the best selection of high quality wall décor that is perfect for their home or office. Browse our catalog of over 300,000 items that include entertainment and specialty posters, decorative prints, and art reproductions. Whether you're looking for your favorite movie or music poster, a framed Monet reproduction, or a print of the Eiffel Tower you will find it at AllPosters.com. Visit our Amazon store today at www.amazon.com/allposters to find Special Offers and search by subject category or artist. AllPosters.com provides unmatched service with a 100% satisfaction guarantee. We ship internationally to over 80 countries. Decorate your... |
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In Vitro Maturation of Human Oocytes: Basic Science to Clinical Applications (Reproductive Medicine and Asst. Reproduction) by Seang Lin Tan (Editor), Ri-Chen Chian (Editor), M. Buckett (Editor) The use of IVM in assisted reproductive technology continues to increase around the world. The major benefit of IVM is that significant numbers of oocytes can be collected from ovaries without recourse to ovarian stimulation. This reduces the costs, time, and risks associated with conventional IVF. Although initially limited to women with polycystic ovary syndrome who were at higher risk of problems following ovarian stimulation, IVM is increasingly used in women with normal ovulatory menstrual cycles. This authoritative text covers the current scientific knowledge of oocyte development and the understanding behind the techniques involved in the clinical application of IVM in assisted reproductive technologies. Short Contents |
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Oocyte Donation by L.A. Salamonsen (Editor), D.L. Healy (Editor) This book comprises papers from a symposium on oocyte donation, held on 22-24 November 1991, in Melbourne, Australia. The symposium was sponsored by Serono, and presented by the Department of Obstetrics and Gynaecology, and the Centre for Reproductive Biology, Monash University. |
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