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CDX2 — A protein that promotes leukemia
March 08, 2007Researchers from Harvard Medical School, Boston, have found that most individuals with acute myeloid leukemia (AML) inappropriately express a protein known as CDX2 in their leukemic cells. CDX2 regulates the expression of a number of genes that encode members of the HOX family of proteins, which might provide a new set of targets for the treatment of individuals with AML.
In the study, which appears online on March 8 in advance of publication in the April print issue of the Journal of Clinical Investigation, Stefan Fröhling and colleagues show that the gene encoding CDX2 is expressed in 90% of the patients with AML that they analyzed. Moreover, reducing the amount of CDX2 in human AML cell lines decreased their ability to proliferate, indicating that CDX2 has a causal role in the pathogenesis of AML. Further evidence of this was provided by the observation that mouse hematopoietic cells engineered to express CDX2 were induced to proliferate and were able to cause full-blown AML when transplanted into mice. Expression of CDX2 in the mouse hematopoietic cells induced altered expression of a number of genes that encode HOX family of proteins, leading the authors to conclude that aberrant expression of CDX2 drives the dysregulated HOX gene expression observed in most individuals with AML.
Journal of Clinical Investigation
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Anti-cancer drug prevents, reverses cardiovascular damage in mouse model of premature aging disorder
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New insights into the regulation of PTEN tumor suppression function
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Children's national co-leads nationwide study of landmark sickle cell treatment
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Newly discovered molecular switch helps decide cell type in early embryo development
Researchers have discovered a central molecular switch in fruit fly embryos that opens new avenues for studying the causes of birth defects and cancer in humans. Writing about their study in the Aug. 12 Developmental Cell, scientists at Cincinnati Children's Hospital Medical Center determined the switch to be a main tuning mechanism for instructing cells whether to form sensory nerves or blood cells in different parts of the body.
McGill researchers overcome chemotherapy resistance in the lab
Researchers from McGill University's Faculty of Medicine have discovered a compound that reduces resistance to chemotherapy agents used to treat cancer. Their results were published in the June issue of The Journal of Clinical Investigation (JCI).
Crucial Factors in Lymphoma Development and Survival Discovered
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