 |
|
Genes may determine success of hip replacement surgery
March 15, 2007The success of long term hip replacement surgery may lie in the genes, suggests research published ahead of print in the Annals of the Rheumatic Diseases.
The researchers analysed genetic variations in 312 people, just over half of whom (162) had problems after hip replacement in the 10 years following surgery.
Among those with symptoms, 91 had early signs of "aseptic loosening," which describes a condition in which the artificial joint comes loose and the surrounding bone begins to dissolve. The other 71 patients had deep-seated infection, which occurs when the body is unable to control infection caused by bacteria colonising the artificial implants.
DNA samples were taken from all participants to test for genetic variations in genes responsible for generating matrix metalloproteinase 1, or MMP1 for short, interleukin 6, and vitamin D synthesis.
MMP1 is an enzyme that breaks down collagen, the main protein found in bone and cartilage, while interleukin 6 is a chemical involved in bone metabolism and the immune response.
Vitamin D synthesis is important for strong healthy bones.
Variations in the interleukin 6 gene did not seem to have any effect. But those with variations in MMP1 were more than three times as likely to have aseptic loosening as those who did not carry the genetic variation.
And variations in the vitamin D receptor gene almost doubled the chances of bone dissolution and deep infection.
The authors conclude that if confirmed in other research, these findings could be used to predict long term success in patients undergoing hip replacement surgery. And they could also be used to develop targeted genetic treatments.
BMJ-British Medical Journal
DNA samples were taken from all participants to test for genetic variations in genes responsible for generating matrix metalloproteinase 1, or MMP1 for short, interleukin 6, and vitamin D synthesis.
MMP1 is an enzyme that breaks down collagen, the main protein found in bone and cartilage, while interleukin 6 is a chemical involved in bone metabolism and the immune response.
Vitamin D synthesis is important for strong healthy bones.
Variations in the interleukin 6 gene did not seem to have any effect. But those with variations in MMP1 were more than three times as likely to have aseptic loosening as those who did not carry the genetic variation.
And variations in the vitamin D receptor gene almost doubled the chances of bone dissolution and deep infection.
The authors conclude that if confirmed in other research, these findings could be used to predict long term success in patients undergoing hip replacement surgery. And they could also be used to develop targeted genetic treatments.
BMJ-British Medical Journal
Hip Replacement Surgery Current Events and Hip Replacement Surgery News RSSTrimming US health care spending will require new approaches, study finds
Slowing the growth in U.S. health care spending will most likely require adoption of an array of strategies as well as an improved approach to moving promising strategies into widespread use, according to a new analysis by the RAND Corporation.
Study outlines strategies to test new payment models for health care
A new RAND Corporation study outlines methods that might be used to test a novel payment system for medical care that would provide doctors, hospitals and other health providers a set fee for treating an ailment such as hip replacement surgery.
How often do hip and knee replacements need revision?
A comprehensive study using nationwide data on hip and knee replacements in England has found that one in seventy-five patients require a revision of their joint replacement after three years.
NIST measuring device aims to up hip operation success
Researchers at the National Institute of Standards and Technology (NIST) are developing state-of-the-art measuring techniques, similar to those used in making aerospace components fit together precisely, that soon could improve success rates for hip replacement surgery.
New biomedical device uses nanotechnology to monitor hip implant healing, may reduce wait times
It is so small, you can barely see it, but a microsensor created by University of Alberta engineers may soon make a huge difference in the lives of people recovering from hip replacement surgery.
Anti-inflammatory drugs following hip replacement surgery could harm rather than help
The use of anti-inflammatory drugs following hip replacement surgery could do more harm than good.
Bayer launches Phase III clinical study of Trasylol in elective spinal fusion surgery
Bayer Pharmaceuticals Corporation (NYSE: BAY) today announced the initiation of a Phase III clinical trial to evaluate the safety and efficacy of Trasylol® (aprotinin injection) in reducing blood loss and the need for transfusion in adult patients undergoing elective spinal fusion surgery.
Smith & Nephew launches Oxinium - a significant technological advance to finding a hip replacement that will last a lifetime
1 April 2004, London, UK - A breakthrough in hip replacement technology from orthopaedic specialists, Smith & Nephew, means that nine million people who suffer with arthritis or chronic hip injury in the UK can now benefit from the new Oxinium hip, which could last their lifetime due to its superior strength and endurance. It also means that younger patients who have suffered severe pain and immobility while waiting years to be offered a hip replacement, may no longer have to. In the UK, of the nine million people who suffer with arthritis, 50,000 need hip replacements each year due to osteoarthritis, but orthopaedic surgeons have traditionally delayed joint replacement surgery in patients y
Need for hip replacements could double within next 30 years
Researchers estimated the likely numbers of hip replacements needed in the UK according to projected changes in population, numbers in each age band, and data from Sweden, which has a similar universal health care system and equivalent rates of osteoarthritis, but where attempts have been made to prioritise demand.
More Hip Replacement Surgery Current Events and Hip Replacement Surgery News Articles
 |
Your Complete Guide To Total Hip Replacements: Before, During, And After Surgery (An Idyll Arbor Personal Health Book) by Jennifer Frantin (Author) |
 |
Hip And Knee Surgery: A Patient's Guide To Hip Replacement, Hip Resurfacing, Knee Replacement, And Knee Arthroscopy by Robert E. Kennon (Author) This friendly and informative book is written by an orthopaedic surgeon specializing in joint replacement and related surgeries, including hip resurfacing and knee arthroscopy. It contains useful information for patients who are considering treatment for hip or knee arthritis and related conditions. Clear and informative chapters explain in plain English what to expect before, during, and after hospitalization, including post-operative exercises and rehabilitation recommendations. Illustrated sections discuss hip and knee surgeries, nonoperative treatment options, surgical approaches, the latest minimally invasive surgery techniques, implant materials and designs (such as ceramic versus metal bearings), and potential complications of surgery. Robert Edward Kennon, MD, is a board certified... |
 |
What Your Doctor May Not Tell You About(TM) Hip and Knee Replacement Surgery: Everything You Need to Know to Make the Right Decisions (What Your Doctor May Not Tell You About...) by Ronald P. Grelsamer (Author) Readers get the facts they need to make informed decisions about hip and knee replacement surg-eries-the two most common joint replacements in America. Hundreds of thousands of Americans suffer from painful, deteriorating joints-and for many, surgery is their only option for relief. Now, Dr. Ronald P. Grelsamer gives readers all the information they need to decide whether hip or knee replacement is the right choice. From the history and evolution of joint implants to the significant differences between types of implants and surgeries, he arms readers with the need-to-know facts for a lasting recovery, including a step-by-step physical program to recover from surgery in the shortest time possible. Dr. Grelsamer also examines the risks and limitations, informing readers under which... |
 |
Sock Aid with Loop Handle by The Wright Stuff Molded plastic frame allows the sock to be slipped over the form and then pulled into the foot. Rubber self-adhesive pad (included) may be added to provide a non-slip resistance to the sock and can be placed in the best position for the individual user. With this useful aid, users can successfully don socks without assistance.Formed Sock Aid with Cord Loop Handle Features:Allows the sock to be pulled onto the foot.Rubber self adhesive pad provides a non-slip resistance to the sock.Foam hand-grips make it much easier to grasp.Formed Sock Aid with Cord Loop Handle Specifications:Braided cord line.Molded plastic sock aid. |
|
The Implant ~ Hip Replacement Surgery Also With: PBS (Producer) | |
 |
Preparing For Surgery Wonderful, powerful CD for use before surgery. Many studies show people prepared in this way remain relaxed, comfortable, heal more quickly and have fewer complications. Redo of 2006 edition. |
 |
Hip Replacement Kit - with 18" Stainless Steel Shoehorn by Active Forever Hip Replacement Kit |
|
Surgical Treatment of Periprosthetic Fractures After Total Hip Replacement Starring: James B. Stiehl | |
 |
Out on a Limb Also With: Warner Bros. (Producer) |
 |
Soap Assistant Soap Holder by Soap Assistant No more dropping soap on the shower floor. Eliminates bending to pick up dropped soap. Just insert your favorite soap through the nylon casing and soap suds onto your wash cloth or skin. Use over and over again. Also, good to use if you have arthritis as it makes holding the soap easier. |
| © 2009 BrightSurf.com |