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In preeclampsia, researchers identify proteins that cause blood vessel damage
March 19, 2007Proteins released by the placenta may damage blood vessels in women with preeclampsia (PE), according to an abstract presented by Yale School of Medicine researchers at the Society for Gynecologic Investigation Conference March 17 in Reno, Nevada.
In PE, a complication of pregnancy linked to life-threatening increases in high blood pressure after 20 weeks of gestation, it has long been recognized that substances called "microparticles" released by the placenta damage maternal blood vessels. Researchers at Yale, led by Seth Guller, sought to detect whether specific proteins were found in microparticles.
The team, including researchers from Berne, Switzerland, studied placentas obtained from patients with preeclampsia who had uncomplicated pregnancies delivered at term by cesarean section. They found that microparticles released from the placenta contain a protein that regulates clot formation (plasminogen activator inhibitor-1). They also found that microparticles contain soluble Flt-1, which inhibits blood vessel growth, and that microparticles contain extremely high levels of plasminogen activator inhibitor-2, a placental protein with no known function.
"In this study, we demonstrate for the first time that microparticles released by the placenta may contain factors that damage maternal blood vessels in preeclampsia," said Guller, associate professor in the Department of Obstetrics, Gynecology & Reproductive Sciences.
Guller said for this study, the team only detected whether specific proteins were found in microparticles. "In the future, we will determine whether they are biologically active—promote damage in vessel culture models—and whether they are present in the blood of women with preeclampsia," said Guller.
Yale University
"In this study, we demonstrate for the first time that microparticles released by the placenta may contain factors that damage maternal blood vessels in preeclampsia," said Guller, associate professor in the Department of Obstetrics, Gynecology & Reproductive Sciences.
Guller said for this study, the team only detected whether specific proteins were found in microparticles. "In the future, we will determine whether they are biologically active—promote damage in vessel culture models—and whether they are present in the blood of women with preeclampsia," said Guller.
Yale University
Preeclampsia Current Events and Preeclampsia News RSSNew link between pre-eclampsia and diet
A chemical compound found in unpasteurised food has been detected in unusually high levels in the red blood cells of pregnant women with the condition pre-eclampsia.
Pregnancy complications are a stress test for future maternal health and pregnancies
Predicting whether pregnancy complications affect long-term maternal health as well as future pregnancies is at the heart of two studies conducted by researchers in the Department of Obstetrics, Gynecology and Reproductive Sciences at Yale School of Medicine.
Increasing age of mothers in Spain leads to rise in mortality rates
A new study examining the evolution of maternal mortality rates in Spain since 1996 shows a 17% increase in deaths. This trend is linked to the widespread increase in maternal age. The highest death rates are among foreign women and those who live in the province of Malaga.
Complications early in pregnancy or in previous pregnancies adversely affect existing or subsequent pregnancies
Complications in early pregnancy or in previous pregnancies can predict the likelihood of further problems in current or subsequent pregnancies, according to research carried out by an international group of experts.
Taking folic acid for a year before pregnancy may reduce risk of preterm birth
Women who take folic acid supplements for at least one year before they become pregnant may cut their risk of having a premature baby by half, according to research published this week in the online journal, PLoS Medicine.
Management of asthma during pregnancy can optimize health of mother and baby
Pregnant women with asthma, the most common condition affecting the lungs during pregnancy, should actively manage their asthma in order to optimize the health of mother and the baby, according to new management recommendations published in the current issue of the New England Journal of Medicine.
Reducing Health Risks for Women and Children: American Dietetic Association Releases Position Paper on Obesity, Reproduction and Pregnancy Outcomes
Diet and nutrition counseling for virtually all overweight and obese women of childbearing age can reduce health risks associated with excess weight for mothers and children alike, according to a newly released position paper from the American Dietetic Association and the American Society of Nutrition.
The new 'epigenetics:' Poor nutrition in the womb causes permanent genetic changes in the offspring
The new science of epigenetics explains how genes can be modified by the environment, and a prime result of epigenetic inquiry has just been published online in The FASEB Journal: You are what your mother did not eat during pregnancy.
1 in 7 U.S. Teens Is Vitamin D Deficient
One in seven American adolescents is vitamin D deficient, according to a new study by researchers in the Department of Public Health at Weill Cornell Medical College. The findings are published in the March issue of the journal Pediatrics and were presented at the Pediatric Academic Societies' Annual Meeting in May 2008.
A reversal of thinking: How women with lupus can increase chance for healthy pregnancies
In the not so distant past, women with systemic lupus erythematosus (SLE), an autoimmune disease, were advised not to have children, and if they became pregnant, to have therapeutic abortions to prevent severe flares of their lupus.
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Pre-eclampsia: Etiology and Clinical Practice by Fiona Lyall (Editor), Michael Belfort (Editor) Pre-eclampsia is one of the leading causes of death and disability in mothers and babies. Over four million women worldwide will develop the disorder every year. This book, written by an international team of experts, focuses on both the scientific basis of pre-eclampsia and its management. The basic science section contains up-to-date reviews of the most exciting research developments in pre-eclampsia. The clinical chapters provide a comprehensive review of the pertinent literature, highlighting recent data and new ideas or developments in current management. There is a section in each chapter (where relevant) that deals with practical management, giving clinicians a formulated treatment plan that they can implement directly. The book will be of interest to all professionals interested... |
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Baby Nathan by Denise Davis (Author) Denise Davis, MSW, LSW, was born in Hammond, Indiana, in 1972. She was raised by a single mother since the age of ten when her father died in a tragic accident. Focusing on her academics, she worked hard during her school years and earned a master’s degree in social work from Loyola University in 2002. She currently works in Merrillville, Indiana, providing psychotherapy to children and adolescents. She is a wife and mother of four children, one of which was a stillborn twin named Nathan. This is Nathan’s story, how his short life and death sent Denise on the most challenging journey of her life. |
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Preeclampsia Medical Guide by Qontro Medical Guides (Author) The Preeclampsia Medical Guide is a publication which has been designed to better help readers understand Preeclampsia. This Qontro Medical Guide has been designed with the reader in mind, and is a useful information source for readers at all levels looking to learn more about Preeclampsia. The Preeclampsia Medical Guide is highly recommended for those interested in understanding and learning more about Preeclampsia. |
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Omron Elite 7300W Womens Avanced Blood Pressure Monitor by Omron FDA approved for women during pregnancy. Clinically validated for use by pregnant women, who are at significant risk for high blood pressure and pre-eclampsia |
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L Arginine 750 mg, 60 Capsules - Pharmaceutical Grade by Club Natural Arginine (also called L arginine) is a semi-essential amino acid involved in numerous areas of human biochemistry. Arginine is also well known as a precursor to nitric oxide (NO), a key component of endothelial-derived relaxing factor, a messenger molecule involved in a variety of endothelium-dependent physiological effects.* Take a look at a highly popular and effective sexual enhancement product, Passion Rx - click on your right below the Passion Rx bottle image. We have a high reorder rate for this product formulated by world renowned herbal expert and best selling author Ray Sahelian, M.D. Passion Rx does not have arginine. History of L Arginine :: L Arginine was first isolated in 1886. In 1932, L arginine was found to be required for the generation of urea, which is necessary for... |
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