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Scientists use saliva's 'diagnostic alphabets' to diagnose disease
March 22, 2007Today, during the 85th General Session of the International Association for Dental Research, scientists are reporting that the use of saliva for clinical detection of major human diseases is only a few years away. Intense research is ongoing to discover diagnostic saliva biomarkers. A necessary prerequisite is to know, in a comprehensive manner, the informative biomarkers in saliva: the diagnostic alphabets. Like languages, which are synthesized from a foundation of alphabets, there are multiple diagnostic languages and thus diagnostic alphabets in saliva. The salivary proteome and the salivary transcriptome are two diagnostic alphabets that are ready for translational and clinical applications.
The human salivary proteome is a consortium effort by three National Institute of Dental and Craniofacial Research-supported research groups (Scripps/Rochester; UCSF, and UCLA), leading to the identification of over 1,500 proteins in saliva. The salivary transcriptome revealed ~3,000 mRNA species in saliva, of which 185 are common among all healthy subjects examined.
Using the salivary proteome and transcriptome as diagnostic alphabets to search for diagnostic signatures, the investigators have found five salivary proteins and four salivary RNA to be highly discriminatory for oral cancer (>90% clinical accuracy). They have also examined the saliva from patients with the autoimmune disease Sjögren's Syndrome, and have found a small subset of the salivary proteome and transcriptome to be highly discriminatory for this disease.
International & American Association for Dental Research
International & American Association for Dental Research
Saliva Current Events and Saliva News RSSDartmouth researchers get personal with genetics
Two recent studies by Dartmouth researchers use individual genetic data to reveal the powers and limits of our current understanding of how the genome influences human health and what genes can reveal about the ancestry of the people of New Hampshire.
Anti-smoking law helps waiters to quit smoking
Researchers from the Catalan Institute of Oncology have studied the impact of the law banning smoking in public places such as bars and restaurants on those working in these places.
Vet says owners should exercise with their dogs based on specific needs to prevent obesity
People and their dogs both need physical activity to fight obesity, and there are many exercises that owner and pet can do together that can improve their health and their relationship, according to a Kansas State University expert.
MicroRNA in human saliva may help diagnose oral cancer
Researchers continue to add to the diagnostic alphabet of saliva by identifying the presence of at least 50 microRNAs that could aid in the detection of oral cancer, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research.
University of Maryland researchers identify gene variant linked to effectiveness of plavix
Researchers at the University of Maryland School of Medicine have identified a common gene variant carried by as many as a third of the general population that is believed to play a major role in determining why people do not respond to a popular anti-clotting medication, Plavix.
Dental researchers confirm microRNAs as biomarkers for oral cancer detection
A new study published by researchers at the UCLA School of Dentistry substantiates the effectiveness of measuring the microRNAs present in saliva to detect oral squamous cell carcinoma.
Vet scientists' work on diagnostic, intervention tools for h1n1 helps human health lab, too
If some day you are tested for the H1N1 virus without the painful prick of a needle, thank a pig -- and a team of Kansas State University researchers and their collaborators who are connecting animal and human health.
Open wide and say 'zap'
A group of researchers in Australia and Taiwan has developed a new way to analyze the health of human teeth using lasers.
Researchers find genetic link between physical pain and social rejection
UCLA psychologists have determined for the first time that a gene linked with physical pain sensitivity is associated with social pain sensitivity as well.
Sleep patterns in children and teenagers could indicate risk for depression, researcher finds
Sleep patterns can help predict which adolescents might be at greatest risk for developing depression, a researcher at UT Southwestern Medical Center has found in a five-year study.
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