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Scientists use saliva's 'diagnostic alphabets' to diagnose disease
March 22, 2007Today, during the 85th General Session of the International Association for Dental Research, scientists are reporting that the use of saliva for clinical detection of major human diseases is only a few years away. Intense research is ongoing to discover diagnostic saliva biomarkers. A necessary prerequisite is to know, in a comprehensive manner, the informative biomarkers in saliva: the diagnostic alphabets. Like languages, which are synthesized from a foundation of alphabets, there are multiple diagnostic languages and thus diagnostic alphabets in saliva. The salivary proteome and the salivary transcriptome are two diagnostic alphabets that are ready for translational and clinical applications.
The human salivary proteome is a consortium effort by three National Institute of Dental and Craniofacial Research-supported research groups (Scripps/Rochester; UCSF, and UCLA), leading to the identification of over 1,500 proteins in saliva. The salivary transcriptome revealed ~3,000 mRNA species in saliva, of which 185 are common among all healthy subjects examined.
Using the salivary proteome and transcriptome as diagnostic alphabets to search for diagnostic signatures, the investigators have found five salivary proteins and four salivary RNA to be highly discriminatory for oral cancer (>90% clinical accuracy). They have also examined the saliva from patients with the autoimmune disease Sjögren's Syndrome, and have found a small subset of the salivary proteome and transcriptome to be highly discriminatory for this disease.
International & American Association for Dental Research
International & American Association for Dental Research
Saliva Current Events and Saliva News RSSMeasuring and modeling blood flow in malaria
When people have malaria, they are infected with Plasmodium parasites, which enter the body from the saliva of a mosquito, infect cells in the liver, and then spread to red blood cells.
On the Trail of a Vaccine for Lyme Disease: Yale Researchers Target Tick Saliva
A protein found in the saliva of ticks helps protect mice from developing Lyme disease, Yale researchers have discovered. The findings, published in the November 19 issue of Cell Host & Microbe, may spur development of a new vaccine against infection from Lyme disease, which is spread through tick bites.
Toward explaining why hepatitis B hits men harder than women
Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women.
Saliva proteins change as women age
In a step toward using human saliva to tell whether those stiff joints, memory lapses, and other telltale signs of aging are normal or red flags for disease, scientists are describing how the protein content of women's saliva change with advancing age.
Study raises concerns about outdoor second-hand smoke
Indoor smoking bans have forced smokers at bars and restaurants onto outdoor patios, but a new University of Georgia study in collaboration with the Centers for Disease Control and Prevention suggests that these outdoor smoking areas might be creating a new health hazard.
Dartmouth researchers get personal with genetics
Two recent studies by Dartmouth researchers use individual genetic data to reveal the powers and limits of our current understanding of how the genome influences human health and what genes can reveal about the ancestry of the people of New Hampshire.
Anti-smoking law helps waiters to quit smoking
Researchers from the Catalan Institute of Oncology have studied the impact of the law banning smoking in public places such as bars and restaurants on those working in these places.
Vet says owners should exercise with their dogs based on specific needs to prevent obesity
People and their dogs both need physical activity to fight obesity, and there are many exercises that owner and pet can do together that can improve their health and their relationship, according to a Kansas State University expert.
MicroRNA in human saliva may help diagnose oral cancer
Researchers continue to add to the diagnostic alphabet of saliva by identifying the presence of at least 50 microRNAs that could aid in the detection of oral cancer, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research.
University of Maryland researchers identify gene variant linked to effectiveness of plavix
Researchers at the University of Maryland School of Medicine have identified a common gene variant carried by as many as a third of the general population that is believed to play a major role in determining why people do not respond to a popular anti-clotting medication, Plavix.
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