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Clues to gene expression in cystic fibrosis will guide research
March 29, 2007Genetics tests could help provide cystic fibrosis (CF) patients with targeted treatment in future, pilot study authors suggest. Results from a French clinical trial published today in BMC Medicine show how a small percentage of CF sufferers with a rare genetic stop mutation responded positively to gentamicin treatment.
Aleksander Edelman and Isabelle Sermet-Gaudelus of Faculté de Médicine Necker in Paris led collaborators from several French institutions studying how the antibiotic gentamicin affected CF patients with a stop mutation. The team used a dual reporter gene assay first in vitro and then in CF patients. The study found that a small subgroup of patients with the Y122X mutation, found mainly in inhabitants of Reunion island, responded to gentamicin treatment.
Cystic fibrosis is caused by mutations in the gene that encodes the Cystic Fibrosis Transmemrane Conductance Regulator (CFTR) protein. Over 1500 mutations have been described since this gene's discovery. Premature stop mutations, which includeY122X, are found in around 10% of CF patients. Gentamicin reversed stop codons in the Y122X gene, and helped restore the CFTR protein, improving patients' respiration.
Gentamicin itself may not be an ideal drug option, as it may cause serious side effects for some patients, including ear and kidney damage. The authors suggest that other drugs, such as amikacin or PTC124, with a comparable mode of action and fewer side effects, may have treatment potential. The in vitro method used to predict the trial's outcome could be a first step to developing treatments effective for patients with CF and other diseases where premature stop codons play a role.
BioMed Central
Gentamicin itself may not be an ideal drug option, as it may cause serious side effects for some patients, including ear and kidney damage. The authors suggest that other drugs, such as amikacin or PTC124, with a comparable mode of action and fewer side effects, may have treatment potential. The in vitro method used to predict the trial's outcome could be a first step to developing treatments effective for patients with CF and other diseases where premature stop codons play a role.
BioMed Central
Gentamicin Current Events and Gentamicin News RSSBUSM researchers find gram-negative rods in two Philippine neonatal intensive care units
Researchers at Boston University School of Medicine (BUSM) have found a high frequency of multidrug-resistant Gram-negative rods (GNRs) in two of the largest neonatal intensive care units (NICUs) in the city of Manila, Philippines.
New findings raise questions about process used to identify experimental drug
A study by National Institutes of Health (NIH) researchers has revealed surprising new insights into the process used to initially identify an experimental drug now being tested in people with cystic fibrosis and muscular dystrophy.
Milk may help bacteria survive against low levels of antibiotics
Milk may help prevent potentially dangerous bacteria like Staphylococcus from being killed by antibiotics used to treat animals, scientists heard today (Monday 8 September 2008) at the Society for General Microbiology's Autumn meeting being held this week at Trinity College, Dublin.
Poultry workers at increased risk of carrying antibiotic-resistant E. coli
Poultry workers in the United States are 32 times more likely to carry E. coli bacteria resistant to the commonly used antibiotic, gentamicin, than others outside the poultry industry, according to a recent study conducted by researchers at the Johns Hopkins Bloomberg School of Public Health.
Electrical implant steadies balance disorder in animals
Hearing and balance experts at Johns Hopkins report successful testing in animals of an electrical device that partly restores a damaged or impaired sense of balance.
New approach could lower antibiotic requirements by 50 times
Steven Hagens, previously at the University of Vienna, told Chemistry & Industry, the magazine of the SCI, that certain bacteriophages, a type of virus that infects bacteria, can boost the effectiveness of antibiotics gentamicin, gramacidin or tetracycline.
New approach could lower antibiotic requirements by 50 times
Antibiotic doses could be reduced by up to 50 times using a new approach based on bacteriophages.
New Treatment - First in Years - Demonstrated For Dangerous Staph Infections
Duke University Medical Center researchers have demonstrated in an international clinical trial the effectiveness and safety of a new drug for treating bloodstream and heart infections caused by Staphylococcus aureus bacteria, a major cause of sickness and death worldwide.
Aspirin shows promise in combating a common, antibiotic-induced hearing loss
Around the world, inexpensive antibiotics known as aminoglycosides have been used for the past 60 years in the battles against acute infections and tuberculosis as antibacterial prophylaxis in cystic fibrosis patients and in other conditions.
Antibiotic resistant bacteria frequently transmitted between intensive care patients
Bacteria with resistance to multiple antibiotics will become more common in intensive care units unless hospitals improve their hygiene standards. Research published in Critical Care this week shows that there is an "unexpectedly high" level of transmission of bacteria between intensive care patients.
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Effect of Cassia auriculata Linn. Root extract on cisplatin and gentamicin-induced renal injury.: An article from: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology by S. Annie (Author), P.L. Rajagopal (Author), S. Malini (Author) This digital document is an article from Phytomedicine: International Journal of Phytotherapy & Phytopharmacology, published by Thomson Gale on August 1, 2005. The length of the article is 3558 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Effect of Cassia auriculata Linn. Root extract on cisplatin and gentamicin-induced renal injury. Author: S. Annie Publication: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology (Magazine/Journal) Date: August 1, 2005 Publisher: Thomson Gale Volume: 12 Issue: 8 Page: 555(6) Distributed by... | |
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BD BBL Sensi-Disc Gentamicin Susceptibility Test Discs by BD Diagnostic Systems, Clinical Susceptibility Test Discs; BBL Sensi-Disc; Antibiotic/Antimicrobial Agent: Gentamicin; 10ug; 50 cartridges/Pack; 50 discs per cartridge |
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Resveratrol protects auditory hair cells from gentamicin toxicity.(ORIGINAL ARTICLE)(Clinical report): An article from: Ear, Nose and Throat Journal by Sharouz Bonabi (Author), Antje Caelers (Author), Arianne Monge (Author), Alex Huber (Author), Daniel Bodmer (Author) This digital document is an article from Ear, Nose and Throat Journal, published by Vendome Group LLC on October 1, 2008. The length of the article is 3161 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser. Citation Details Title: Resveratrol protects auditory hair cells from gentamicin toxicity.(ORIGINAL ARTICLE)(Clinical report) Author: Sharouz Bonabi Publication: Ear, Nose and Throat Journal (Magazine/Journal) Date: October 1, 2008 Publisher: Vendome Group LLC Volume: 87 Issue: 10 Page: 570(4) Article Type: Clinical report Distributed by Gale, a part of Cengage... | |
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BD BBL Sensi-Disc Gentamicin Susceptibility Test Discs, 10-Cartridge Pack by BD Diagnostic Systems, Clinical Susceptibility Test Discs; BBL Sensi-Disc; Antibiotic/Antimicrobial Agent: Gentamicin; 10μg; 50 discs per cartridge; 10 cartridges/Pack |
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Long-term follow-up after gentamicin application via the Silverstein MicroWick in the treatment of Meniere's disease.: An article from: Ear, Nose and Throat Journal by Samuel L., III Hill (Author), Nicholas B. Digges (Author), Herbert Silverstein (Author) This digital document is an article from Ear, Nose and Throat Journal, published by Thomson Gale on August 1, 2006. The length of the article is 2258 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Long-term follow-up after gentamicin application via the Silverstein MicroWick in the treatment of Meniere's disease. Author: Samuel L., III Hill Publication: Ear, Nose and Throat Journal (Magazine/Journal) Date: August 1, 2006 Publisher: Thomson Gale Volume: 85 Issue: 8 Page: 494(3) Distributed by Thomson... | |
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Columbia Agar w/LHB Gentamicin and Penicillin (10 per pack) by Hardy Diagnostics Columbia Agar with 5% Lysed Horse Blood, 5mg/1 Gentamicin, and 0.1mg/1 Penicillin, 15x100mm plate, by Hardy Diagnostics. (Columbia Agar with Lysed Horse Blood, Gentamicin and Penicillin) For the selective isolation of penicillin-resistant Streptococcus pneumoniae. Refrigerate on arrival. | |
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Once daily high-dose gentamicin to prevent infection in open fractures of the tibia shaft: A preliminary investigation. (*).(Statistical Data Included): An article from: Southern Medical Journal by George V. Russell (Author), Chantae King (Author), Carmen G. May (Author), Albert W. Pearsall (Author) This digital document is an article from Southern Medical Journal, published by Southern Medical Association on December 1, 2001. The length of the article is 3953 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Once daily high-dose gentamicin to prevent infection in open fractures of the tibia shaft: A preliminary investigation. (*).(Statistical Data Included) Author: George V. Russell Publication: Southern Medical Journal (Refereed) Date: December 1, 2001 Publisher: Southern Medical Association Volume: 94 Issue: 12 Page: 1185(7) Article Type:... | |
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Columbia Agar w/LHB and Gentamicin (10 per pack) by Hardy Diagnostics Columbia Agar with 5% Lysed Horse Blood and 5mg/1 Gentamicin, 15x100mm plate, by Hardy Diagnostics. (Columbia Agar with Lysed Horse Blood and Gentamicin) For the selective isolation of Streptococcus pneumoniae. Refrigerate on arrival. | |
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The effect of treatment with the medicinal plant Rhazya stricta Decne on gentamicin nephrotoxicity in rats.: An article from: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology by B.H. Ali (Author) This digital document is an article from Phytomedicine: International Journal of Phytotherapy & Phytopharmacology, published by Urban & Fischer Verlag on July 1, 2002. The length of the article is 3428 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: The effect of treatment with the medicinal plant Rhazya stricta Decne on gentamicin nephrotoxicity in rats. Author: B.H. Ali Publication: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology (Refereed) Date: July 1, 2002 Publisher: Urban & Fischer Verlag Volume: 9 Issue: 5 Page:... | |
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Results of a European proficiency test for the detection of streptomycin/dihydrostreptomycin, gentamicin and neomycin in milk by ELISA and biosensor methods [An article from: Analytica Chimica Acta] by V. Gaudin (Author), N. Cadieu (Author), P. Sanders (Author) This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2005. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: An interlaboratory study was proposed to the European Community and Third Countries National Reference Laboratories (NRL) for the analysis of aminoglycoside residues in bovine milk by ELISA. This test was intended to allow the participants to control their aminoglycoside ELISA methods and also to compare the performance of various ELISA kits (neomycin, gentamicin, streptomycin and DHS) in bovine milk. Twelve random coded frozen samples were sent in dried ice (including 2 blank samples and 10 spiked milk... |
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