 |
|
Scientists identify cells responsible for relapse after treatment in common childhood cancer
March 29, 2007Approximately 20% of children with ALL will experience a relapse of their disease following treatment. Of these, most will never be cured.
"We have previously shown that these relapses were due to small numbers of cells which survived the treatment administered to the patient," said Prof Norris.
"However, it has been unclear whether these cells developed resistance to chemotherapy during the course of treatment or if they were already present in the child at the time their cancer was diagnosed."
The findings of this study demonstrate that relapse in ALL patients can result from a minor, but intrinsically resistant subpopulation of cells, present from the time of diagnosis. Undetected at diagnosis because of their very small numbers, this population of leukaemia cells remained in the patient's body throughout the disease and continued to thrive even after the major population of sensitive leukaemia cells were destroyed and the patient appeared to have gone into remission.
"We have shown, for the first time, that children with a greater number of these cells at diagnosis are more likely to experience relapse much sooner after treatment.
"Without new strategies to identify and attack these cells early in treatment, relapse appears inevitable for these patients," said Prof Norris.
"Our ability to characterise these cells means that researchers can now develop treatments which specifically target the cells and are more effective than current options.\\\
Research Australia
The findings of this study demonstrate that relapse in ALL patients can result from a minor, but intrinsically resistant subpopulation of cells, present from the time of diagnosis. Undetected at diagnosis because of their very small numbers, this population of leukaemia cells remained in the patient's body throughout the disease and continued to thrive even after the major population of sensitive leukaemia cells were destroyed and the patient appeared to have gone into remission.
"We have shown, for the first time, that children with a greater number of these cells at diagnosis are more likely to experience relapse much sooner after treatment.
"Without new strategies to identify and attack these cells early in treatment, relapse appears inevitable for these patients," said Prof Norris.
"Our ability to characterise these cells means that researchers can now develop treatments which specifically target the cells and are more effective than current options.\\\
Research Australia
Childhood Cancers Current Events and Childhood Cancers News RSSAnti-psychotic drugs could help fight cancer
The observation that people taking medication for schizophrenia have lower cancer rates than other people has prompted new research revealing that anti-psychotic drugs could help treat some major cancers.
PET Can Help Guide Treatment Decisions for a Common Pediatric Cancer
A new study published in the August issue of The Journal of Nuclear Medicine shows that positron emission tomography (PET) is an important tool for depicting the extent of neuroblastoma in some patients, particularly for those in the early stages of the disease.
Common household pesticides linked to childhood cancer cases in Washington area
A new study by researchers at the Georgetown's Lombardi Comprehensive Cancer Center finds a higher level of common household pesticides in the urine of children with acute lymphoblastic leukemia (ALL), a cancer that develops most commonly between three and seven years of age.
U of M Researchers Find Childhood Cancer Risk Rises with Mother's Age
Research from the Masonic Cancer Center, University of Minnesota indicates that a baby born to an older mother may have a slightly increased risk for many of the cancers that occur during childhood.
Genetic finding could lead to targeted therapy for neuroblastoma
Researchers have identified a genetic glitch that could lead to development of neuroblastoma, a deadly form of cancer that typically strikes children under 2.
USC researchers identify DNA mutation that occurs at beginning point of T-cell lymphoma
Researchers at the Keck School of Medicine of the University of Southern California (USC) have identified a key mechanism that causes chromosomes within blood cells to break-an occurrence that marks the first step in the development of human lymphoma.
New therapy enlists immune system to boost cure rate in a childhood cancer
A multicenter research team has announced encouraging results for an experimental therapy using elements of the body's immune system to improve cure rates for children with neuroblastoma, a challenging cancer of the nervous system.
Mutant genes in high-risk childhood leukemias identified
A research team has pinpointed a new class of gene mutations, which identify cases of childhood acute lymphoblastic leukemia (ALL) that have a high risk of relapse and death.
University of Kansas graduate student researcher takes aim at deadly brain tumors
Natalie Ciaccio, a fourth-year graduate student researcher in the Department of Pharmaceutical Chemistry at the University of Kansas, is investigating what might be an ideal target for anti-cancer drug therapy, and she is focusing her work on brain tumors specifically.
New research shows lower educational outcomes for survivors of childhood cancer
New research funded by the Canadian Cancer Society has discovered poor educational achievement and learning difficulties for some childhood cancer survivors, especially those diagnosed with brain tumours.
More Childhood Cancers Current Events and Childhood Cancers News Articles
 |
Childhood Cancer Survivors: A Practical Guide to Your Future (Childhood Cancer Guides) by Nancy Keene (Author), Wendy Hobbie (Author), Kathy Ruccione (Author) More than 270,000 children, teens, and adults in the Untied States are survivors of childhood cancer. The surgery, radiation, chemotherapy, and stem cell transplants used to cure children can affect growing bodies and developing minds. If survivors know of these potential problems, they can take steps to identify, cope with, or treat them early if they do develop. The second edition of "Childhood Cancer Survivors" charts the territory for survivors by providing state-of-the-art information about: Medical late effects from treatment Emotional aspects of surviving cancer Schedules for follow-up care Challenges in the heathcare system Lifestyle choices to maximize health Discrimination in employment of insurance Authors Keene, Hobbie, and Ruccione are experts in the field of childhood... |
 |
Living With Childhood Cancer : A Practical Guide to Help Families Cope by Leigh A. Woznick (Author), Carol D. Goodheart (Author) Like a natural disaster, the diagnosis that your child has cancer can leave you and your family feeling helpless. How do you explain the disease to the child and to his or her siblings? How can you communicate your child’s needs to the hospital staff? What are the best ways to reduce the physical side effects and the emotional distress of treatment? How will you, your child or teenager, and the rest of your family cope with cancer, and what can you do to help? When and where do you find good psychological help for your child or your family? How do you manage financial and school issues? How can you foster your child’s development and self-esteem? More than 12,000 American children will be diagnosed with cancer this year, and roughly 75% will survive. In addition to excellent... |
 |
Childhood Cancer: A Parent's Guide to Solid Tumor Cancers, 2nd Edition by Honna Janes-Hodder (Author), Nancy Keene (Author) This second edition of the most complete parent guide available, features detailed and precise medical information about solid tumor childhood cancers, including neuroblastoma, Wilms tumor, liver tumors, soft tissue sarcomas, and bone sarcomas. In addition, it offers day-to-day practical advice on how to cope with procedures, hospitalization, family and friends, school, social and financial issues, communication, feelings, and, if therapy is not successful, the difficult issues of death and bereavement. Woven among the medical details and the practical advice are the voices of parents and children who have lived with cancer and its treatments. Parents who read this book will encounter medical facts simply explained, advice to ease their daily lives, and tools to be strong advocates for... |
 |
Cure Childhood Cancer Awareness Sweatshirt Large White by Shop Zeus |
 |
Celebration of Life: Musicians Against Childhood Cancer by Various Artists Recorded "live" at the annual Musicians Against Childhood Cancer bluegrass festival in Columbus, Ohio, Celebration of Life is a 2-CD set that features spirited performances by many of the top artists in bluegrass today. 136 bluegrass musicians. 37 songs. 2 CDs. 1 special reason -- to benefit St. Jude Children's Research Hospital. You can feel good knowing that 100% of the net proceeds from the sale of Celebration of Life will be donated to St. Jude Children's Research Hospital. |
 |
Cure Childhood Cancer Awareness Oval Magnet by Magnet Inc. Model: M-OV-CCCA; Cure Childhood Cancer Awareness Oval Magnet. High Quality UV protected printed vinyl backed with thick .30 mil magnetic material. Great fundraiser for awareness organizations, schools, churches, or your fundraiser group. Dimensions: 4 1/4" x 6 1/2" |
 |
Cole...I love You to the Moon and Back by Aaron Dean Ruotsala (Author) Aaron Dean Ruotsala, 24-year-old husband, father, business owner, and pilot shares a true story about a heart-wrenching experience he calls the best and worst experience of a lifetime. This story will provoke you to laughter, tears, and cause you to examine yourself and your role as a human on this temporal journey. His prayer is that all who read this amazing story will learn from the experience in which they had no choice, to realize that when life brings you to the darkest, deepest, loneliest point imaginable, you will recognize what really matters in life. So, please laugh, cry, share, examine, and mostly enjoy this book that is certain to make you ask the question: "What if this happened to me?" The reality is that it could. Recommended It's amazing how God used a single... |
 |
Childhood Cancer Awareness Brown Genuine Swarovski Crystal Bracelet by SilverSpeck.com This Beautiful Brown Genuine Swarovski Crystal Bracelet Is the Perfect Bracelet you have been waiting for. It has a Sparking Glimmer and is beaded on a Comfort Stretch band. Crystal beads can also be used to create your own jewelry!. Very Stylish and Pretty! |
|
Childhood Cancer Awareness Ribbon Mouse Pad by MyHeritageWear.com The Childhood Cancer Ribbon proudly displayed on a mouse pad. There is no better way to achieve awareness for the meaning of the Childhood Cancer Ribbon than to display it on your mouse pad for everyone to see. The mouse pad measures at 9.25 x 7.75, it is machine washable, and the colors will not fade or run. Start gaining awareness today by presenting your Childhood Cancer Ribbon mouse pad at work or at home. It is certain to keep your mouse rolling in style all while gaining support and awareness! | |
|
|
Cure Childhood Cancer Awareness Oval Decal by Magnet Inc. Model: D-OV-CCCA; Cure Childhood Cancer Awareness Oval Decal. High Quality UV protected printed vinyl material. Great fundraisers for awareness organizations, schools, churches, or your fundraiser group. Dimensions: 4 1/4" x 6 1/2" |
| © 2009 BrightSurf.com |