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New genetic biomarkers could predict coronary heart disease
April 02, 2007New genetic markers may be able to predict whether a person is likely to have coronary heart disease (CAD) in the future. Research carried out by Dr. M. Balasubramanyam and Dr.V.Mohan at the Madras Diabetes Research Foundation (India) shows that people who are pre-diabetic or who have Type 2 diabetes have much shorter telomeres1 and, since these people are prone to CAD, an early test could indicate their susceptibility and help them to alter their lifestyle to avoid or delay the onset of the disease. This work will be presented by Dr Adaikala Koteswari at the Society for Experimental Biology's Annual Main Meeting on Sunday 1st April 2007.
Tests have been carried out on pre-diabetics and Type 2 diabetics which have shown that telomere shortening is greater as a person progresses from being pre-diabetic through to being type-2 diabetic. Diabetics are more susceptible to oxidation and inflammation which could be the one of the reasons for telomere shortening and so an early indication of their telomeres starting to shorten could indicate the onset of diabetes and ultimately be a predictor for CAD. In other words, telomere shortening in prediabetics could predict those predisposed subjects who are at the cross-road of developing type 2 diabetes and cardiovascular disease.
1 Telomeres have been compared with the plastic tips on shoelaces because they prevent chromosome ends from fraying and sticking to each other, which would otherwise result in genomic instability. Telomeres are also thought to be the "clock" that regulates how many times an individual cell can divide. Telomeric sequences shorten each time the DNA replicates. When the telomeres reach a critically short length, the cell stops dividing and ages (senesces) which may cause or contribute to age-related diseases. Telomeres are essential regulators of the cellular lifespan and chromosome integrity, however it has recently been shown that telomeres may also play a role in complex genetic disorders such as hypertension and diabetes.
Society for Experimental Biology
Society for Experimental Biology
Diabetes News and Current Diabetes Events RSSClass of diabetes drugs carries significant cardiovascular risks
A class of oral drugs used to treat type 2 diabetes may make heart failure worse, according to an editorial published online in Heart Wednesday by two Wake Forest University School of Medicine faculty members.
Not all fat is created equal
A Temple University study finds fat in obese patients is "sick" when compared to fat in lean patients.
Young Type-2 Diabetic Men Suffer Low Testosterone Levels, Study Shows
Young men with type 2 diabetes have significantly low levels of testosterone, endocrinologists at the University at Buffalo have found -- a condition that could have a critical effect on their quality of life and on their ability to father children.
Early trigger for type-1 diabetes found in mice, Stanford scientists report
Scientists at the Stanford University School of Medicine are shedding light on how type-1 diabetes begins.
Findings challenge common practice regarding glucose control for critically ill patients
An analysis of randomized trials indicates that for critically ill adults, tight glucose control is not associated with a significantly reduced risk of death in the hospital, but is associated with an increased risk of hypoglycemia, calling into question the recommendation by many professional societies for tight glucose control for these patients.
Chronic stress alters our genetic immune response
Most people would agree that stress increases your risk for illness and this is particularly true for severe long-term stresses, such as caring for a family member with a chronic medical illness.
Low cholesterol associated with cancer in diabetics
Low levels of LDL cholesterol as well as high levels are associated with cancer in patients with type 2 diabetes.
Potential diabetes treatment selectively kills autoimmune cells from human patients
In experiments using blood cells from human patients with diabetes and other autoimmune disorders, Massachusetts General Hospital (MGH) researchers have confirmed the mechanism behind a potential new therapy for type 1 diabetes.
Scientists discover leptin can also aid type 1 diabetics
Terminally ill rodents with type 1 diabetes have been restored to full health with a single injection of a substance other than insulin by scientists at UT Southwestern Medical Center.
Nano-sized 'trojan horse' to aid nutrition
Researchers from Monash University have designed a nano-sized "trojan horse" particle to ensure healing antioxidants can be better absorbed by the human body.
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