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New genetic biomarkers could predict coronary heart disease
April 02, 2007New genetic markers may be able to predict whether a person is likely to have coronary heart disease (CAD) in the future. Research carried out by Dr. M. Balasubramanyam and Dr.V.Mohan at the Madras Diabetes Research Foundation (India) shows that people who are pre-diabetic or who have Type 2 diabetes have much shorter telomeres1 and, since these people are prone to CAD, an early test could indicate their susceptibility and help them to alter their lifestyle to avoid or delay the onset of the disease. This work will be presented by Dr Adaikala Koteswari at the Society for Experimental Biology's Annual Main Meeting on Sunday 1st April 2007.
Tests have been carried out on pre-diabetics and Type 2 diabetics which have shown that telomere shortening is greater as a person progresses from being pre-diabetic through to being type-2 diabetic. Diabetics are more susceptible to oxidation and inflammation which could be the one of the reasons for telomere shortening and so an early indication of their telomeres starting to shorten could indicate the onset of diabetes and ultimately be a predictor for CAD. In other words, telomere shortening in prediabetics could predict those predisposed subjects who are at the cross-road of developing type 2 diabetes and cardiovascular disease.
1 Telomeres have been compared with the plastic tips on shoelaces because they prevent chromosome ends from fraying and sticking to each other, which would otherwise result in genomic instability. Telomeres are also thought to be the "clock" that regulates how many times an individual cell can divide. Telomeric sequences shorten each time the DNA replicates. When the telomeres reach a critically short length, the cell stops dividing and ages (senesces) which may cause or contribute to age-related diseases. Telomeres are essential regulators of the cellular lifespan and chromosome integrity, however it has recently been shown that telomeres may also play a role in complex genetic disorders such as hypertension and diabetes.
Society for Experimental Biology
Society for Experimental Biology
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Diabetes Current Events and Diabetes News RSSADA releases updated position paper on vegetarian diets
The American Dietetic Association has released an updated position paper on vegetarian diets that concludes such diets, if well-planned, are healthful and nutritious for adults, infants, children and adolescents and can help prevent and treat chronic diseases including heart disease, cancer, obesity and diabetes.
U finds treatment that significantly slows progression of eye damage in persons with type 1 diabetes
University of Minnesota Medical School researcher Michael Mauer, M.D., has found a treatment that significantly slows the progression of eye injury in people with type 1 diabetes, a common complication caused by this disease.
Lap-band weight-loss surgery can reverse metabolic syndrome in obese teens
A new study of obese adolescents has shown that laparoscopic gastric banding surgery -- the "Lap-Band" procedure -- not only helps them achieve significant weight loss but can also improve and even reverse metabolic syndrome, reducing their risk for cardiovascular disease and diabetes.
Biomarker of breathing control abnormality associated with hypertension and stroke
A study in the July 1 issue of the journal SLEEP identified a distinct ECG-derived spectrographic phenotype, designated as narrow-band elevated low frequency coupling (e-LFCNB), that is associated with prevalent hypertension, stroke, greater severity of sleep disordered breathing and sleep fragmentation in patients suffering from obstructive sleep apnea (OSA).
Joint replacement patients with diabetes greatly benefit from controlled glucose
Diabetics undergoing total joint replacement often are at a higher risk of experiencing complications after surgery due to various pre-existing health conditions.
UT researcher: Interferon alpha can delay full onset of type I diabetes
A low dose of oral interferon alpha shows promise in preserving beta cell function for patients with newly diagnosed type 1 diabetes, or juvenile diabetes.
New tool finds best heart disease and stroke treatments for patients with diabetes
Researchers from North Carolina State University and Mayo Clinic have developed a computer model that medical doctors can use to determine the best time to begin using statin therapy in diabetes patients to help prevent heart disease and stroke.
Polycystic ovarian syndrome: New light on its causes and its effect on brothers
Researchers have found evidence that chronic disease in either a mother or father can create unfavourable conditions in the womb that are associated with the development of polycystic ovarian syndrome (PCOS) in daughters.
Women with cystic fibrosis can have safe and successful fertility treatment
Women with cystic fibrosis can have fertility treatment to help them have babies without any long-term adverse effects on either themselves or their children.
Patients with moderate to severe periodontitis need evaluation for heart disease risk
Additional research is called for and patients with moderate to severe periodontitis should receive evaluation and possible treatment to reduce their risk of atherosclerotic cardiovascular disease (CVD).
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