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Fat overrides effects of vitamin C
April 02, 2007Fats in our stomach may reduce the protective effects of antioxidants such as vitamin C. Scientists at the University of Glasgow found that in the presence of lipid the ability of antioxidants, such as ascorbic acid (the active component of vitamin C), to protect against the generation of potential cancer-forming compounds in the stomach is less than when no lipids are present. "Our results illustrate how diet can influence gastric biochemistry", says Emilie Combet, the post-doctoral researcher working on the project, who will be presenting her results at the Society of Experimental Biology's Annual Main Meeting on Monday 2nd of April.
The incidence of cancer of the proximal stomach has been increasing over the last 20 years for which environmental factors, such as diet, certainly play a part. Nitrite, which is present in our saliva and is derived from nitrate in our diet, is thought to be a pre-carcinogen for gastric cancer. When it is swallowed and enters the acidic environment of the stomach, nitrite spontaneously forms nitrosating species able to convert a range of targets, such as secondary amines and bile acids, into carcinogenic N-nitrosocompounds. Antioxidants such as ascorbic acid protect against the formation of these nitrosocompounds by converting the nitrosating species back into nitric oxide (NO). However, NO diffuses rapidly to lipids, where it reacts with oxygen to reform nitrosating species. The presence of lipids therefore overrides the protective effect of vitamin C against the formation of harmful compounds.
Society for Experimental Biology
Antioxidants Current Events and Antioxidants News RSSNew evidence that dark chocolate helps ease emotional stress
The "chocolate cure" for emotional stress is getting new support from a clinical trial published online in ACS' Journal of Proteome Research.
'Escaped' proteins add to hearing loss in elderly, UF researchers find
Age-related hearing loss is the most common sensory disorder among the elderly. But scientists are still trying to figure out what cellular processes govern or contribute to the loss.
Ice cream researchers making sweet strides with 'functional foods'
A comfort food, a tasty treat, an indulgence - ice cream conjures feelings of happiness and satisfaction for millions. Ice cream researchers at the University of Missouri have discovered ways to make ice cream tastier and healthier and have contributed to ice cream development and manufacturing for more than a century.
Powerful pumpkins, super squash
Carotenoids, the family of yellow to red pigments responsible for the striking orange hues of pumpkins and the familiar red color of vine-ripe tomatoes, play an important role in human health by acting as sources of provitamin A or as protective antioxidants.
Breeding better broccoli
Carotenoids-fat-soluble plant compounds found in some vegetables-are essential to the human diet and reportedly offer important health benefits to consumers.
Daily dose of color may boost immunity this flu season
Hoping to keep the flu at bay? A strong immune system helps. Enjoying the bounty of colorful fruits and vegetables available right now can be an important step toward supporting your family's immune system this cold/flu season.
Scientists discover influenza's Achilles heel: Antioxidants
As the nation copes with a shortage of vaccines for H1N1 influenza, a team of Alabama researchers have raised hopes that they have found an Achilles' heel for all strains of the flu-antioxidants.
Propolis has proved to be a product with ability to have beneficial effects for health
Growing concerns about health has caused the scientific community to focus their interest on investigating functional foods which contribute to boosting the prevention and reduction of the risk of suffering from certain illnesses.
Phytochemicals in plant-based foods could help battle obesity, disease
The cheeseburger and French fries might look tempting, but eating a serving of broccoli or leafy greens first could help people battle metabolic processes that lead to obesity and heart disease, a new University of Florida study shows.
Herbal tonic for radiotherapy
Antioxidant extracts of the leaves of the Gingko biloba tree may protect cells from radiation damage, according to a study published in the International Journal of Low Radiation.
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