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Aspirin discovery may improve cancer treatments
April 06, 2007Salicylates, including aspirin, are used to treat a range of inflammatory conditions and can be used to prevent diseases such as cancer, but the way aspirin works is not yet fully understood.
In a paper published in the prestigious Journal of Biological Chemistry in April, Professor Bryan Williams, Director of the Monash Institute of Medical Research, led a collaborative study that investigated the effects of salicylates on the inhibition of protein synthesis.
"Our research showed that treating human cells with salicylates results in the phosphorylation of the translation initiation factor eIF2'-, thus inhibiting protein synthesis," Professor Williams said.
"Inhibiting or slowing down protein synthesis reduces the accumulation of incorrectly folded proteins in cells, which reduces cellular stress and allows protein synthesis to return to normal."
Under conditions of cellular stress, eIF2'- is phosphorylated by a group of proteins called stress-activated kinases. One of these is protein kinase R-like endoplasmic reticulum kinase (PERK).
The research showed that salicylates caused an early increase in the phosphorylation of eIF2'- in normal mouse cells, but not in cells deficient in PERK. Aspirin was shown to activate PERK. Moreover, although aspirin inhibited protein synthesis in normal cells, this did not occur significantly in cells deficient in PERK. Thus PERK plays an important role in the inhibition of protein synthesis by salicylates.
"Our research into the mechanisms by which salicylates inhibit protein synthesis could lead to the design of more effective aspirin-like drugs for the treatment of diseases such as cancer," Professor Williams said.
Research Australia
"Inhibiting or slowing down protein synthesis reduces the accumulation of incorrectly folded proteins in cells, which reduces cellular stress and allows protein synthesis to return to normal."
Under conditions of cellular stress, eIF2'- is phosphorylated by a group of proteins called stress-activated kinases. One of these is protein kinase R-like endoplasmic reticulum kinase (PERK).
The research showed that salicylates caused an early increase in the phosphorylation of eIF2'- in normal mouse cells, but not in cells deficient in PERK. Aspirin was shown to activate PERK. Moreover, although aspirin inhibited protein synthesis in normal cells, this did not occur significantly in cells deficient in PERK. Thus PERK plays an important role in the inhibition of protein synthesis by salicylates.
"Our research into the mechanisms by which salicylates inhibit protein synthesis could lead to the design of more effective aspirin-like drugs for the treatment of diseases such as cancer," Professor Williams said.
Research Australia
Nasal polyps from analgesics
If a patient develops respiratory problems after taking analgesics, this indicates that the active substances are poorly tolerated.
Smaller packs of analgesics have reduced overdose deaths
The number of deaths from self poisoning with paracetamol and salicylates has decreased significantly since legislation limiting the number of tablets per pack was introduced in the United Kingdom in 1998, finds a study in this week's BMJ. Data including drug related deaths, cases of liver poisoning, numbers of liver transplantations, and sales data, were used to assess the impact of the legislation. The number of tablets in packets of paracetamol and salicylate preparations decreased markedly in the 12 months after the legislation. The annual number of deaths from paracetamol poisoning decreased by 21% and the number from salicylates decreased by 48%. There was also a decrease in the numbe
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AMMONIA SALICYLATE #1 & #2 REAGENTS 10PK TwinPak by Top Dawg Pet Supplies Aqua Test_Kit Kordon by Kordon - Get Fast Shipping and Low Prices at PetsWarehouse.com on over 43,000 Pet Supplies such as Dog Food, Dog Supplies, Cat Food, Cat Supplies, Bird Food, Bird Supplies, Aquarium Supplies and Fish Supplies. We offer our customers the largest selection of Pet Supplies online in the world, when we say "everything for your pet" it's true, we have it. Customer satisfaction guaranteed! |
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