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Genes set scene for metastasis
April 12, 2007Biologists at Memorial Sloan-Kettering Cancer Center (MSKCC) have identified a set of genes expressed in human breast cancer cells that work together to remodel the network of blood vessels at the site of the primary tumor. These genes were also found to promote the spread of breast cancer to the lungs. The study, conducted in mice and reported in this week's Nature, helps to explain how cancer metastasis can occur and highlights targets for therapeutic treatment.
Metastasis — the leading cause of mortality in cancer patients — entails numerous biological functions that collectively enable cancerous cells from a primary site to disseminate and overtake distant organs. A number of genes are already known to contribute to the spread of breast cancer cells to the lungs.
Using genetic and pharmacological approaches, Joan Massagué, PhD, Chair of MSKCC's Cancer Biology and Genetics Program and a Howard Hughes Medical Institute Investigator, and colleagues showed how four genes facilitate the formation of new tumor blood vessels, the release of cancer cells into the bloodstream, and the penetration of tumor cells from the bloodstream into the lung. The gene set comprises EREG (an epidermal growth factor receptor ligand), the cyclooxygenase COX2, and MMP1 and MMP2 (matrix enzymes that are expressed in human breast cancer cells).
The researchers conclude that drug combinations that target one or more of the proteins encoded by these genes may prove useful for treating metastatic breast cancer.
Memorial Sloan-Kettering Cancer Center
The researchers conclude that drug combinations that target one or more of the proteins encoded by these genes may prove useful for treating metastatic breast cancer.
Memorial Sloan-Kettering Cancer Center
Breast Cancer Current Events and Breast Cancer News RSSResearcher: 'Optical biopsy' for breast cancer increasingly accurate
But women may not have to endure the medical costs, stress and potential complications that accompany such invasive biopsies forever. A University of Florida biomedical engineering researcher is making progress on an "optical biopsy" that has the potential to determine whether growths are cancerous without ever puncturing the skin.
Plastic surgeons offer microsurgery technique for breast reconstruction, tummy tuck after mastectomy
Since her teens, Jennifer Jablon had watched family members deal with breast cancer during their 40s, 50s, and 60s. She wondered whether it would be her fate too.
Experimental agent reduces breast cancer metastasis to bone
Researchers have reduced breast cancer metastasis to bone using an experimental agent to inhibit ROCK, a protein that was found to be over-expressed in metastatic breast cancer.
American Dietetic Association Releases Updated Position Paper Promoting and Supporting Breastfeeding
The American Dietetic Association has released an updated position paper on breastfeeding that details health benefits for both infants and mothers and encourages promotion of breastfeeding whenever possible.
Weight Training Boosts Breast Cancer Survivors' Body Image and Satisfaction with Intimate Relationships, Penn Study Shows
In addition to building muscle, weightlifting is also a prescription for self-esteem among breast cancer survivors, according to new University of Pennsylvania School of Medicine research.
Early-stage, HER2-positive breast cancer patients at increased risk of recurrence
Early-stage breast cancer patients with HER2 positive tumors one centimeter or smaller are at significant risk of recurrence of their disease, compared to those with early-stage disease who do not express the aggressive protein, according to a study led by researchers at The University of Texas M. D. Anderson Cancer Center.
Adapting Space-Industry Technology to Treat Breast Cancer
Researchers at Rush University Medical Center and Argonne National Laboratory are collaborating on a study to determine if an imaging technique used by NASA to inspect the space shuttle can be used to predict tissue damage often experienced by breast cancer patients undergoing radiation therapy.
An exquisite container
In campy old movies, Lucretia Borgia swans around emptying powder from her ring into wine glasses carelessly left unattended. The poison ring is usually a confection of gold filigree holding a cabochon or faceted gemstone that can be broken to empty the ring's contents. It is invariably enormous - so large it is rather odd nobody seems to notice it.
MicroRNA-mediated metastasis suppression
Metastases are responsible for over 90% of cancer deaths. In the upcoming issue of G&D, Dr. Robert Weinberg (MIT) and colleagues lend molecular insight into how microRNAs suppress tumor metastasis.
Study shows hormone replacement therapy decreases mortality in younger postmenopausal woman
Hormone replacement therapy (HRT) to treat menopausal estrogen deficiency has been in widespread use for over 60 years. Several observational studies over the years showed that HRT use by younger postmenopausal women was associated with a significant reduction in total mortality; available evidence supported the routine use of HRT to increase longevity in postmenopausal women.
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New Balance Women's Lace Up X Out Breast Cancer Tech Tee (Athletic Grey, Medium) by New Balance The New Balance X Out Breast Caner Tee has a soft hand and clearly states how everyone feels! |
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1149 WOMENS VINTAGE BLACK ADJUSTABLE FATIGUE CAP w/PINK STRIPES & ''BREAST CANCER'' RIBBON by Rothco A portion of these proceeds go to the Babylon Breast Cancer Coalition- For Life, For Hope, For Change, For the Future Visit www.babylonbreastcancer.org for more information. |
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New Balance Women's Lace Up X Out Breast Cancer Tech Tee (Athletic Grey, Small) by New Balance The New Balance X Out Breast Caner Tee has a soft hand and clearly states how everyone feels! |
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Pink Ribbon BREAST CANCER Crystal Pin by MyJewelThief Genuine Austrian Crystal Layered in 18k Gold Pink Enameled Ribbon Pins. Measures approx. 1 1/2" X 1". Each individually carded. Wonderful for fund raisers! |
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Breast Cancer Survival Manual, Fourth Edition: A Step-by-Step Guide for the Woman With Newly Diagnosed Breast Cancer by John Link (Author) A completely updated edition of the definitive guide for patients with breast cancer The new fourth edition of The Breast Cancer Survival Manual provides essential updates on treatment and care, enhancing the basic information that has made this the most trusted guide for women diagnosed with breast cancer for the past decade. This edition includes the most current advice on • getting a second opinion: why it’s important, what questions   to ask, and how to decide which team of doctors is best for you • updates on genetic testing and how doctors are using   the results to tailor care for each patient • navigating new types of radiation, the herceptin   breakthrough, and improved reconstruction surgeries Conscious of the rapidly evolving spectrum of... |
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Find the Cure Pink Breast Cancer Awareness Wristband by sci Find The Cure Pink Breast Cancer Awareness wristband |
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PINK RIBBON BREAST CANCER BEADED KEY CHAIN Purse Charm by MyJewelThief Beaded Pink Ribbon Breast Cancer Awareness Keychains. A mix of 4 styles! BEADS GALORE! Great for keychains, purse charms and more! Great for fund raisers! Meaures approx. 5" long! |
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Trudeau Cool Off Hydration Bottle - Breast Cancer Pink - 24oz by Trudeau For each Bottle sold Trudeau will donate 5% to The Breast Cancer Research Foundation |
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Breast Cancer Awareness Ribbon Promise of a Cure Cuff Bracelet by Silver Insanity This Cuff Bracelet Will Fit up to a 8" Wrist and is 3/8" Wide Crafted of a Silver Toned Base Metal and Brought to High Polish Shine Set with a Bright Pink Breast Cancer Awareness Ribbon and Inscribed With The Phrase "Promise of a Cure" |
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Sunbeam SlumberRest Camelot Microplush Heated Throw, Breast Cancer Awareness Pink by Sunbeam Soft comfortable fabric that you can cuddle up with anywhere in your house. Use it on the couch while curling up to read a good book or in a chair while watching your favorite show. This throw is 50"x60", with a primstyle control which features 3 warming settings and 3 hour auto-off. So turn on your warming blanket, turn off your thermostat and save on your heating bill. Warm up to a good cause! Sunbeam is joining the fight against breast cancer. Through the purchase of this pink throw, sunbeam will donate $1.00 to city of hope for breast cancer research, treatment and education* up to $25,000. Program ends april 30, 2009. "to save lives and end breast cancer forever by empowering people, ensuring quality care for all, and energizing science to find the cures." *to learn more about... |
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