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Genes set scene for metastasis
April 12, 2007Biologists at Memorial Sloan-Kettering Cancer Center (MSKCC) have identified a set of genes expressed in human breast cancer cells that work together to remodel the network of blood vessels at the site of the primary tumor. These genes were also found to promote the spread of breast cancer to the lungs. The study, conducted in mice and reported in this week's Nature, helps to explain how cancer metastasis can occur and highlights targets for therapeutic treatment.
Metastasis — the leading cause of mortality in cancer patients — entails numerous biological functions that collectively enable cancerous cells from a primary site to disseminate and overtake distant organs. A number of genes are already known to contribute to the spread of breast cancer cells to the lungs.
Using genetic and pharmacological approaches, Joan Massagué, PhD, Chair of MSKCC's Cancer Biology and Genetics Program and a Howard Hughes Medical Institute Investigator, and colleagues showed how four genes facilitate the formation of new tumor blood vessels, the release of cancer cells into the bloodstream, and the penetration of tumor cells from the bloodstream into the lung. The gene set comprises EREG (an epidermal growth factor receptor ligand), the cyclooxygenase COX2, and MMP1 and MMP2 (matrix enzymes that are expressed in human breast cancer cells).
The researchers conclude that drug combinations that target one or more of the proteins encoded by these genes may prove useful for treating metastatic breast cancer.
Memorial Sloan-Kettering Cancer Center
The researchers conclude that drug combinations that target one or more of the proteins encoded by these genes may prove useful for treating metastatic breast cancer.
Memorial Sloan-Kettering Cancer Center
Breast Cancer Current Events and Breast Cancer News RSSNew statistical model could help reduce breast-lesion biopsies
A new method of characterizing breast lesions found during an MRI exam could result in fewer biopsies of benign tumors with the benefits of reduced pain and expense for patients and providers, according to a paper that will be presented today (Sunday, Nov. 30) at the annual meeting of the Radiological Society of North America (RSNA).
Breast cancer treatment offers better outcome to women with implants
Women with early-stage breast cancer who have undergone breast augmentation may be treated successfully with a partial-breast radiation treatment called brachytherapy, according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA).
Study identifies double-balloon enteroscopy as cost-effective approach for obscure GI bleeding
A cost-effectiveness analysis conducted by researchers at Stanford University Hospital in Calif., shows that an initial double-balloon enteroscopy (DBE) is a cost-effective approach for patients with obscure gastrointestinal (GI) bleeding.
Study identifies causes of bone loss in breast cancer survivors
Osteoporosis is a growing concern among breast cancer survivors and their doctors, because certain cancer drugs can cause bone loss.
2 new compounds show promise for eliminating breast cancer tumors
Two new compounds created by a University of Central Florida professor show early promise for destroying breast cancer tumors.
UNC researchers find clue to stopping breast-cancer metastasis
If scientists knew exactly what a breast cancer cell needs to spread, then they could stop the most deadly part of the disease: metastasis. New research from the University of North Carolina at Chapel Hill School of Medicine takes a step in that direction.
Fear, misconceptions about screenings keep many African-Americans from getting mammograms
Training physicians and caregivers to improve cultural sensitivity and communication with economically disadvantaged African-American patients could influence these women to get mammograms that could save their lives.
New technology could revolutionize breast cancer screening
The world's first radar breast imaging system developed at Bristol University that could revolutionise the way women are scanned for breast cancer, is being trialled at North Bristol NHS Trust (NBT).
Battling bacteria in the blood: Researchers tackle deadly infections
It's a leading cause of death, but no one knows for sure how and why it happens. It's a major source of health care costs, adding days or weeks to the hospital stays and lost work time of millions of people. But no one fully understands how best to fight it.
Mayo Clinic Study Finds Risk Assessment Tool Not Reliable Predictor for Some Women at High Risk of Breast Cancer
A statistical model commonly used to predict the risk of breast cancer in women was not accurate when used to evaluate women with atypical hyperplasia, according to a new Mayo Clinic study published in the Oct. 14, 2008, issue of the Journal of Clinical Oncology.
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