 |
|
Anti-wrinkle compound causes pathological reaction in skin cells
April 12, 2007Researchers from Université Laval's Faculty of Medicine have discovered that a compound commonly used in many antiwrinkle products causes a pathological reaction in skin cells. Guillaume Morissette, Lucie Germain, and François Marceau present their conclusions about the mode of action of this substance—called DMAE—in the latest edition of the British Journal of Dermatology.
DMAE (2-dimethylaminoethanol) is used in many antiwrinkle products dubbed "instant anti-aging face-lifts." This compound, as well as other chemically similar ones, are also found in cosmetics, creams, lipsticks, shampoos, soaps, and baby lotions, although the way they work is not yet understood.
In vitro tests conducted by Dr. Marceau's team revealed that the application of DMAE induces a quick and spectacular swelling of skin cell vacuoles called fibroblasts, which act as reservoirs and interface between the inside and the outside of the cell.
In the hours following the application of DMAE, the researchers observed an important slowing down of cell division—sometimes coming to a complete stop, the inhibition of certain metabolic reactions, and the death of a significant percentage of fibroblasts. The mortality rate of fibroblasts, which varied according to DMAE concentration, was above 25% after 24 hours in the case of a concentration similar to the one resulting from normal use of an antiwrinkle cream. The thickening of the skin induced by the pathological swelling of the fibroblasts would explain the antiwrinkle effect of DMAE, according to the researchers.
"Even though DMAE is similar to medication, there is very little scientific documentation about its pharmacological and toxicological effects," explains Dr. Marceau, who stresses his goal is not to condemn the use of this compound. "We're not saying DMAE is dangerous to people exposed to it, but our results indicate it's time to begin serious research to determine whether or not it poses a health risk."
DMAE is not a unique case in the world of beauty products, continues the researcher. "Several compounds found in cosmetics are just as complex as medication—they are absorbed through the skin, flow through the bloodstream, are expelled by the kidneys, or stocked in cells or even in the liver. Yet, the laws regulating their use are far less restrictive than those regulating drugs," concludes Dr. Marceau.
Université Laval
In the hours following the application of DMAE, the researchers observed an important slowing down of cell division—sometimes coming to a complete stop, the inhibition of certain metabolic reactions, and the death of a significant percentage of fibroblasts. The mortality rate of fibroblasts, which varied according to DMAE concentration, was above 25% after 24 hours in the case of a concentration similar to the one resulting from normal use of an antiwrinkle cream. The thickening of the skin induced by the pathological swelling of the fibroblasts would explain the antiwrinkle effect of DMAE, according to the researchers.
"Even though DMAE is similar to medication, there is very little scientific documentation about its pharmacological and toxicological effects," explains Dr. Marceau, who stresses his goal is not to condemn the use of this compound. "We're not saying DMAE is dangerous to people exposed to it, but our results indicate it's time to begin serious research to determine whether or not it poses a health risk."
DMAE is not a unique case in the world of beauty products, continues the researcher. "Several compounds found in cosmetics are just as complex as medication—they are absorbed through the skin, flow through the bloodstream, are expelled by the kidneys, or stocked in cells or even in the liver. Yet, the laws regulating their use are far less restrictive than those regulating drugs," concludes Dr. Marceau.
Université Laval
Wrinkles Current Events and Wrinkles News RSSIs my robot happy to see me?
People are social creatures. Robots - not so much. When we think of robots, we think of cold, metallic computers without emotion.
Aggressive microdermabrasion induces wound-healing response in aging skin
Microdermabrasion using a coarse diamond-studded instrument appears to induce molecular changes in the skin of older adults that mimic the way skin is remodeled during the wound healing process.
Researchers find demand for cosmetic and surgical procedures in dermatologic surgery rising rapidly
Researchers from Boston University School of Medicine (BUSM) and the Laser and Skin Cancer Center of Indiana, (Carmel, Indiana), found that there has been a dramatic increase in the number of procedures performed and patient demand for dermatologic health care since 2000.
Secrets of insect flight revealed
Researchers are one step closer to creating a micro-aircraft that flies with the manoeuvrability and energy efficiency of an insect after decoding the aerodynamic secrets of insect flight.
Baby boomers' boon? LED light and green tea cream to smooth facial wrinkles
Scientists in Germany are reporting a major improvement in their potential new treatment for facial wrinkles that could emerge as an alternative to Botox and cosmetic surgery.
Dysport proves safe, effective anti-wrinkle treatment, UT Southwestern plastic surgeons find
The new anti-wrinkle facial filler Dysport, which could be used as an alternative to Botox, noticeably reduced frown lines between the eyes, according to users and independent reviewers in a study involving plastic surgeons at UT Southwestern Medical Center.
Non-toxic hull coating resists barnacles, may save ship owners millions
North Carolina State University engineers have created a non-toxic "wrinkled" coating for use on ship hulls that resisted buildup of troublesome barnacles during 18 months of seawater tests, a finding that could ultimately save boat owners millions of dollars in cleaning and fuel costs.
Anti-aging cosmetic reduced wrinkles in clinical trial
Scientists testing a cosmetic anti-ageing product sold on the high street have shown it can clinically reduce wrinkles and improve the appearance of skin damaged by everyday exposure to sunlight.
'Master regulator' of skin formation discovered
Researchers at Oregon State University have found one gene in the human body that appears to be a master regulator for skin development, in research that could help address everything from skin diseases such as eczema or psoriasis to the wrinkling of skin as people age.
Scientists closer to making invisibility cloak a reality
J.K. Rowling may not have realized just how close Harry Potter's invisibility cloak was to becoming a reality when she introduced it in the first book of her best-selling fictional series in 1998. Scientists, however, have made huge strides in the past few years in the rapidly developing field of cloaking. Ranked the number five breakthrough of the year by Science magazine in 2006, cloaking involves making an object invisible or undetectable to electromagnetic waves.
More Wrinkles Current Events and Wrinkles News Articles
 |
RoC Retinol Correxion Deep Wrinkle Night Cream, 1-Ounce Tube by RoC RoC Deep Wrinkle Night Cream visibly reduces expression lines and deep wrinkles. RoC Retinol Correxion Deep Wrinkle Night Cream is an intensive anti-wrinkle treatment that works through the night, visibly reducing expression lines and deep wrinkles. This exclusive combination of pure Retinol and an essential mineral complex is clinically proven to visibly reduce deep wrinkles while you sleep. When you apply, the upper layers of your skin are firmed leading to a visible reduction in expression lines. The formula starts to work immediately as pure Retinol penetrates deep within the skin's surface to help fill in even your deep wrinkles. This product diminishes the appearance of expression lines, visibly reduces even deep wrinkles, moisturizes skin throughout the night, and leaves skin... |
 |
Perry Ellis Men's Long Sleeve Wrinkle Free Shirt,Della Robbia,18 36/37 by Perry Ellis |
 |
Afirm 3X -30 gm by Afirm AFIRM 3x by TxSystems, with the patented APS MICROSPONGE system containing .6% Retinol, is designed to minimize the appearance of aging due to sun damage, fine lines, brown spots and surface roughness. Regular use of AFIRM dramatically transforms your skin, providing a radiant glow. AFIRM should be used as part of a comprehensive skin care and sun avoidance program including the use of sunscreens. Ideal for those unable to tolerate Renova. Use 3x only if advancing from the 2x or if you are currently using an equivalent strength retinol product. Afirm can be irritating! Follow instruction card. Use alone, very sparingly (Pea-sized amount) every other night or less often as tolerated and wait 30 minutes after washing before applying. Not for use if pregnant or nursing. |
 |
Derma e Peptides Plus Double-Action Wrinkle Reverse Creme, 2 oz (56 g) by derma e This revolutionary double-action peptide creme includes two of the most powerful peptides that bio-science has to offer. Formulated with Palmitoyl Pentapeptide to smooth away wrinkles and Acetyl Hexapeptide to relax muscles for healthier, younger-looking skin. Improves skin's resilience, tone and texture and also helps increase collagen and elastin production. A rich and luxurious moisturizing creme that saturates your skin with nutrients and softens even the deepest wrinkles. No animal testing. Made in USA. |
 |
The Wrinkle Cure: Unlock the Power of Cosmeceuticals for Supple, Youthful Skin by Nicholas Perricone (Author) Dr. Perricone's #1 "New York Times" bestselling guide to a better, healthier complexion offers a revolutionary, all-natural, antioxidant program that revitalizes the skin at any age, from the outside and inside. Reissue. |
 |
GUESS Wrinkle Patent Belt with Pearls & St, BLACK (S) by GUESS Pearls and pyramid studs give this black patent leather belt a mix of girlish charm with rockin good looks. Large brass buckle has engraved logo. 1.5 wide Women's Accessories > Belts |
 |
Olay Wrinkle Smoothing Cream, Pro-x, 1.7-Ounce Bottle by Olay Pro-X Olay Professional is at the forefront of science and anti-aging technology. Leading dermatologists and Olay skin scientists have partnered to establish the Olay Professional Advisery Panel for Skin Care Innovation. This team has professionaly designed and professionaly tested these products by selcting anti-aging ingrediants to treat your specific ckin care concern. Through this partnership, Pro-X was created to bring you prescribed regimens to Protect, Treat and Teansform you skin's appearance. Each product in the line contains a unique combination of anti-aging ingredients that are designed to work together for excellent results in treating primary and specific aging skin appearance concerns. Additionally, the products are designed to be used in a daily regimen to provide comprehensive... |
 |
Relastin Skin Revitalizer, 1.7-Ounce Jar by Relastin Don't take our word for it, real women who used Relastin saw visible results: 84% saw a significant improvement in skin firmness. 80% experienced improved elasticity. 75% saw a decrease in fines lines and wrinkles. 89% said it improved their skin's texture. |
 |
Perry Ellis Men's Long Sleeve Wrinkle Free Shirt,Desert Sage,14H 32/33 by Perry Ellis |
 |
Olay Pro-X Wrinkle Treatment, 1-Ounce Bottle by Olay Pro-X Olay Professional is at the forefront of science and anti-aging technology. Leading dermatologists and Olay skin scientists have partnered to establish the Olay Professional Advisery Panel for Skin Care Innovation. This team has professionaly designed and professionaly tested these products by selcting anti-aging ingrediants to treat your specific ckin care concern. Through this partnership, Pro-X was created to bring you prescribed regimens to Protect, Treat and Teansform you skin's appearance. Each product in the line contains a unique combination of anti-aging ingredients that are designed to work together for excellent results in treating primary and specific aging skin appearance concerns. Additionally, the products are designed to be used in a daily regimen to provide comprehensive... |
| © 2009 BrightSurf.com |