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2 heads are better than 1: 2 dysfunctional DNA repair pathways kill tumor cells
April 13, 2007Individuals who inherit two mutant copies of any one of about 12 genes that make the proteins of the Fanconi Anemia (FA) pathway develop FA, which is characterized by increased incidence of cancer and bone marrow failure, among other things. However, individuals with just a single mutant copy of one of these genes are also at increased risk of developing cancer. This occurs when the remaining "good" copy of the gene becomes mutated in a specific cell type, allowing that cell type to form a tumor. However, hope of a new treatment for these cancers has now been provided by researchers from the Dana-Farber Cancer Institute in Boston who suggest that inhibiting the protein ATM might kill these cancer cells.
In the study, which appears online on April 12 in advance of publication in the May print issue of the Journal of Clinical Investigation, Alan D'Andrea and colleagues show that loss of ATM function in human cell lines with a dysfunctional FA pathway caused the cells to die. The dying cells were characterized by high levels of DNA breakage, which is consistent with the fact that FA pathway proteins and ATM are important regulators of two distinct DNA repair pathways. It therefore seems that the ATM pathway of DNA repair keeps the FA pathway-deficient tumor cells alive and that loss of this pathway results in tumor cell death. As FA pathway-deficient tumor cells were shown to be sensitive to an inhibitor of ATM, the authors suggest that ATM might provide a therapeutic target for the treatment of individuals with FA pathway-deficient tumors.
Journal of Clinical Investigation
Tumor Cells Current Events and Tumor Cells News RSSNew cancer target for non-Hodgkin's lymphoma
Physician-scientists from Weill Cornell Medical College have discovered a molecular mechanism that may prove to be a powerful target for the treatment of non-Hodgkin's lymphoma, a type of cancer that affects lymphocytes, or white blood cells.
Cancers' Sweet Tooth May Be Weakness
The pedal-to-the-metal signals driving the growth of several types of cancer cells lead to a common switch governing the use of glucose, researchers at Winship Cancer Institute of Emory University have discovered.
UCLA researchers create 'fly paper' to capture circulating cancer cells
Just as fly paper captures insects, an innovative new device with nano-sized features developed by researchers at UCLA is able to grab cancer cells in the blood that have broken off from a tumor.
'Cross-talk' mechanism contributes to colorectal cancer
Researchers at the University of Wisconsin-Madison School of Medicine and Public Health have identified a molecular mechanism that allows two powerful signaling pathways to interact and begin a process leading to colorectal tumors.
CSHL study shows that some malignant tumors can be shut down after all
Oncologists have had their hands tied because more than half of all human cancers have mutations that disable a protein called p53.
1930s drug slows tumor growth
Drugs sometimes have beneficial side effects. A glaucoma treatment causes luscious eyelashes. A blood pressure drug also aids those with a rare genetic disease.
New Notre Dame study provides insights into the molecular basis of tumor cell behavior
A new study by a team of researchers led by Crislyn D'Souza-Schorey, associate professor of biological sciences at the University of Notre Dame, sheds light on the molecular basis by which tumor cells modulate their surroundings to favor cancer progression.
Immune therapy can protect against or treat later lymphoma
Specially developed immune system cells that target the common Epstein-Barr virus can protect immune-suppressed bone marrow transplant recipients against lymph system disease and cancers that arise from the viral infection.
Study reveals a 'missing link' in immune response to disease
The immune system's T cells have the unique responsibilities of being both jury and executioner. They examine other cells for signs of disease, including cancers or infections, and, if such evidence is found, rid them from the body. Precisely how T cells shift so swiftly from one role to another, however, has been a mystery.
Discovery offers potential new pancreatic cancer treatment
Tiny particles that can carry drugs and target cancer cells may offer treatment hope for those suffering with pancreatic cancer. New research to be presented in November at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting in Los Angeles reveals that tumor-penetrating microparticles (TPM) have been specifically designed to break through hard-to-infiltrate barriers and deliver drugs more effectively and efficiently than the standard form of chemotherapy such as those injected through a vein.
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Cancer Cell Culture: Methods and Protocols (Methods in Molecular Medicine) by Simon P. Langdon (Editor) Western General Hospital, Edinburgh, UK. Describes easy-to-follow methods for guiding researchers on new techniques in cell and molecular biology of cancer, Features the basic concept of cancer cell culture and general techniques used in many cell culture facilities. Also covers the isolation of specific cancer cell types. For researchers. |
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Cure Ovarian Germ Cell Tumor Long Sleeve T-shirt Large White by Shop Zeus |
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Fight Against Germ Cell Tumor Keychain by Design a Product LLC Text on keychain: Fight Against Germ Cell Tumor * Durable acrylic key chain is crystal-clear and double-sided so the artwork or message is seen twice. * Sturdy metal ring holds your keys securely. * Full color printed images or messages are included. * If you have new ideas or need help selecting text for your custom keychains please contact us. * Size: 2 1/8" x 3 1/2" (Approx. business card) |
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Mobile Starring: Keith Allen, Julie Graham, Michael Kitchen, Samantha Bond, Jamie Draven Directed By: Stuart Orme Conspiracy, betrayal, and revenge in the global telecom industry Someone is blowing up mobile-phone towers across England. Messages scrawled in blood-red paint at the scenes proclaim that mobile phones are the instruments of the devil. What’s more, a gunman -- or gunmen -- is shooting cell phone users in mid-conversation. Baffled police investigators scramble to avert public panic. In four interlocking parts, this tense drama peels back the layers of a terrorist conspiracy, gradually revealing the evil at its core. We follow three characters -- a disgraced telecom executive (Michael Kitchen, Foyle’s War), a bitter ex-soldier (Jamie Draven, Billy Elliot), and a disgruntled engineer (Neil Fitzmaurice, Going Off Big Time) -- all united by circumstance or collusion. In a style... |
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Olympian Labs Ip-6, Inositol Hexaphosphate by Olympian Labs Inositol hexaphosphate is a sugar molecule attached to six phosphate molecules. It is found throughout nature, in wheat and rice bran, legumes such as soybeans and virtually every kind of mammalian cell. It plays an important role in regulating vital cellular functions including cell proliferation and differentiation. There has been research on human liver cancer cells that were treated with inositol hexaphosphate and transplanted into mice. They found that inositol hexaphosphate slowed or stopped the growth of liver cancer cells and shrank existing tumors three- to four-fold. Inositol hexaphosphate does not kill cancer cells - it tames them and makes them behave like normal cells. Inositol hexaphosphate decreases proliferation of cancer cells and causes them to differentiate,... |
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Fight Against Extracranial Germ Cell Tumor Long Sleeve T-shirt Large White by Shop Zeus |
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Organic Noni Juice, Morinda Citrifolia, Unflavored, Vegetarian 16 oz by Dynamic Health Laboratories by Dynamic Health It is believed that the Noni (Morinda Citrifolia) tree originated in Southeast Asia about two thousand years ago. Since that time, the precious fruit of the Noni tree has been distributed throughout the islands of the South Pacific, as the tree will only thrive in the delicate ecosystem of the tropics. The great gifts of the Noni fruit are well-known in tropical cultures. Noni Juice (Morinda Citrifolia) has traditionally been used to cleanse and purify the entire system, as a defense against illness, to aid digestion, to heal abrasions, to reduce swelling and inflammation and reduce pain. Dynamic Health Laboratories, Inc. offers a variety of Noni formulas so that you can choose the one that's right for you. Usage: Take 2 tablespoons (1fl.oz) daily on an empty stomach, preferably in the... |
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Atlas of Human Tumor Cell Lines by Robert K.M. Hay (Editor), Jae-Gahb Park (Editor), Adi Gazdar (Editor) Human tumor cells in culture are valuable for studying cancer causes and properties. This convenient reference provides useful information for cancer researchers on commonly used, established tumor cell lines of the major human organ systems. Atlas of Human Tumor Cell Lines includes data about morphological, metabolic, genetic, and growth characteristics of human tumor cells, with morphological characteristics presented in more than 250 photomicrographs. It also contains information for establishing and maintaining human tumor cell lines in culture, and each chapter covers future perspectives. * * Covers well-characterized tumor cell lines from the major human organ systems * Presents over 250 photomicrographs, both phase-contrast... |
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