Promising treatment for post-traumatic stress disorder sleep disturbancesApril 19, 2007For sufferers of Post Traumatic Stress Disorder (PTSD), sleep disturbances are among the most treatment-resistant symptoms and can lead to drug and alcohol abuse and even suicide. Previously, there has been little success in treating these sleep disorders with psychopharmacologic approaches. In a study in the April 15th issue of Biological Psychiatry, researchers have found that an inexpensive, widely available drug was successful in reducing symptoms in chronic PTSD patients. In a placebo-controlled, blinded study of 40 veterans of the Vietnam War (32 subjects), World War II (2), the Korean War (3), the Panama invasion (1) and the first Gulf War (2), prazosin was significantly more effective than placebo in reducing trauma nightmares, improving sleep quality and improving the general clinical condition of the treated patients. Subjects were assessed using three primary outcome measures, the CAPS "recurrent distressing dreams" item, the Pittsburgh Sleep Quality Index (PSQI) and the Clinical Global Impression of Change (CGIC). The CAPS "recurrent distressing dreams" item measures frequency and intensity of trauma-related distressing dreams. The PSQI is a self-report scale assessing sleep quality and sleep disturbance. The CGIC is an investigator rated assessment of change in global clinical status, which was defined in this study as sense of well-being and ability to function in daily activities. Improvements in all three measures were observed, with 71% of the subjects receiving prazosin having "moderately or markedly improved" CGIC scores at the end of the study, compared to 12% of those receiving placebo. Writing in the article, Murray A. Raskind, MD, states, "These results support the therapeutic use of prazosin for PTSD in combat veterans who present with trauma nightmares and sleep disturbance. Clinical experience suggests that prazosin also is beneficial for PTSD trauma nightmares and sleep disturbance in young civilian trauma victims, young veterans of the current conflict in Iraq and Afghanistan and in elderly World War II and Korean War combat veterans and Holocaust survivors." Elsevier Health Sciences |
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| Related Post-traumatic Stress Disorder Current Events and Post-traumatic Stress Disorder News Articles New UAB Study Sheds Light on Brain's Response to Distress, Unexpected Events In a new study, psychologists at the University of Alabama at Birmingham (UAB) are able to see in detail for the first time how various regions of the human brain respond when people experience an unexpected or traumatic event. Psychiatric impact of torture could be amplified by head injury Depression and other emotional symptoms in survivors of torture and other traumatic experiences may be exacerbated by the effects of head injuries, according to a study from the Harvard Program in Refugee Trauma (HPRT), based in the Massachusetts General Hospital (MGH) Department of Psychiatry. Use of cannabinoids (marijuana) could help post-traumatic stress disorder patients Use of cannabinoids (marijuana) could assist in the treatment of post-traumatic stress disorder patients. This is exposed in a new study carried out at the Learning and Memory Lab in the University of Haifa's Department of Psychology. MU Researchers Use Computational Models to Study Fear The brain is a complex system made of billions of neurons and thousands of connections that relate to every human feeling, including one of the strongest emotions, fear. Researchers unravel mystery behind long-lasting memories A new study by researchers at Wake Forest University School of Medicine may reveal how long-lasting memories form in the brain. PTSD associated with higher Alzheimer's/dementia risk; moderate alcohol consumption may lower it Though discoveries about Alzheimer's disease risk factors are often in the news, adults do not know about the relationship between Alzheimer's disease risk and heart health, nor that physical activity can be protective against dementia. Neuroscience research could benefit US Army, yet challenge traditional approaches Advances in neuroscience research could benefit the Army, particularly in areas of soldier training and education. However, an emerging trend of using individual variability in neural processes such as cognition, stress response, and decision making to improve group performance is likely to challenge conventional approaches to training and educating soldiers. Witnessing violence affects kids' health School-aged children who witness violence in urban communities show symptoms of post-traumatic stress. They also suffer physiological effects with a disruption to their normal cortisol production pattern during the day, which may have long-term negative effects on their health. Controlling our brain's perception of emotional events Research performed by Nicole Lauzon and Dr. Steven Laviolette of the Schulich School of Medicine & Dentistry at The University of Western Ontario has found key processes in the brain that control the emotional significance of our experiences and how we form memories of them. Researchers reveal how the brain processes important information Researchers at UT Southwestern Medical Center have shed light on how the neurotransmitter dopamine helps brain cells process important information. More Post-traumatic Stress Disorder Current Events and Post-traumatic Stress Disorder News Articles |
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