Brightsurf Science News and Current Science News Events

 
Email a Friend Send to a friend
Printer Friendly Print Stem cell identity in culture may strongly depend on the cellular microenvironment

Stem cell identity in culture may strongly depend on the cellular microenvironment

April 25, 2007

Identification, isolation and large scale culture of stem cells for potential medical applications is a major challenge in cell biology. In an upcoming PLoS ONE paper, researchers, including Andras Paldi, in Genethon (Evry, France) report, on the basis of experimental observations and computer simulations, that the stem cell identity in culture may strongly depend on the cellular microenvironment.

These observations are in line with the currently emerging view that differentiation is context dependent rather than a pre-programmed attribute of the cells. In practice, this work provide a rationale to research strategies that aim to increase the efficiency of stem cell-related culture methods and, perhaps, even to develop stem cells from already differentiated cells instead of using embryos.





Public Library of Science



Related Stem Cell News Articles Stem Cell News and Current Stem Cell Events RSS Stem Cell News and Current Stem Cell Events RSS
Sugar study is sweetener for stem cell science
Scientists at The University of Manchester are striving to discover how the body's natural sugars can be used to create stem cell treatments for heart disease and nerve damage - thanks to a £370,000 funding boost.

MIT identifies cells for spinal-cord repair
A researcher at MIT's Picower Institute for Learning and Memory has pinpointed stem cells within the spinal cord that, if persuaded to differentiate into more healing cells and fewer scarring cells following an injury, may lead to a new, non-surgical treatment for debilitating spinal-cord injuries.

Standards in stem cell research
Standards in stem cell research help both scientists and regulators to manage uncertainty and the unknown, according to new research funded by the Economic and Social Research Council.

Predicting acute GVHD by gene expression could improve liver stem cell transplant outcomes
Many cell transplants involve the use of stem cells from another human being (known as an allograft), which raises the major concern of the potential for acute graft-versus-host disease (GVHD).

Stem cell chicken and egg debate moves to unlikely arena: the testes
Logic says it has to be the niche. As air and water preceded life, so the niche, that hospitable environment that shelters adult stem cells in many tissues and provides factors necessary to keep them young and vital, must have emerged before its stem cell dependents.

Human embryonic stem cells developed from 4-cell embryo; world first may lessen ethical concerns
For the first time in the world scientists have succeeded in developing human embryonic stem cells (hESCs) from a single cell, or blastomere, of a 4-cell stage embryo.

Novel hydrogel systems for dentin regeneration
Dental caries, or tooth decay, continues to be the most prevalent infectious disease in the world, presenting significant public health challenges and socio-economic consequences.

Small protein may have big role in making more bone and less fat
A small protein may have a big role in helping you make more bone and less fat, researchers say.

Researchers link early stem cell mutation to autism
In a breakthrough scientific study published today in the Proceedings of the National Academy of Sciences, scientists at the Burnham Institute for Medical Research have shown that neural stem cell development may be linked to Autism.

Nerve cells derived from stem cells and transplanted into mice may lead to improved brain treatments
Scientists at the Burnham Institute for Medical Research have, for the first time, genetically programmed embryonic stem (ES) cells to become nerve cells when transplanted into the brain, according to a study published today in The Journal of Neuroscience.
More Stem Cell News Articles
My Sister's Keeper: A Novel
by Jodi Picoult


The Oxygen Revolution: Hyperbaric Oxygen Therapy: The Groundbreaking New Treatment for Stroke, Alzheimer's, Parkinson's, Arthritis, Autism, Learning Disabilities and More
by Paul G. Harch, Virginia Mccullough


Embryo: A Defense of Human Life
by Robert P. George, Christopher Tollefsen


Irreparable Harm
by Randy D. Singer


Cell of Cells: The Global Race to Capture and Control the Stem Cell
by Cynthia Fox


Sex, Science, and Stem Cells
by Diana DeGette


Miracle Stem Cell Heart Repair: (For Heart Attack, Heart Failure and Bypass Patients)
by Christian Wilde


Essentials of Stem Cell Biology


The Human Embryonic Stem Cell Debate: Science, Ethics, and Public Policy (Basic Bioethics)


The Stem Cell Divide: The Facts, the Fiction, and the Fear Driving the Greatest Scientific, Political, and Religious Debate of Our Time
by Michael Bellomo


© 2008 BrightSurf.com