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Stem cell identity in culture may strongly depend on the cellular microenvironment
April 25, 2007Identification, isolation and large scale culture of stem cells for potential medical applications is a major challenge in cell biology. In an upcoming PLoS ONE paper, researchers, including Andras Paldi, in Genethon (Evry, France) report, on the basis of experimental observations and computer simulations, that the stem cell identity in culture may strongly depend on the cellular microenvironment.
These observations are in line with the currently emerging view that differentiation is context dependent rather than a pre-programmed attribute of the cells. In practice, this work provide a rationale to research strategies that aim to increase the efficiency of stem cell-related culture methods and, perhaps, even to develop stem cells from already differentiated cells instead of using embryos.
Public Library of Science
Stem Cell News and Current Stem Cell Events RSSSugar study is sweetener for stem cell science
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MIT identifies cells for spinal-cord repair
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Standards in stem cell research help both scientists and regulators to manage uncertainty and the unknown, according to new research funded by the Economic and Social Research Council.
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Stem cell chicken and egg debate moves to unlikely arena: the testes
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Human embryonic stem cells developed from 4-cell embryo; world first may lessen ethical concerns
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Novel hydrogel systems for dentin regeneration
Dental caries, or tooth decay, continues to be the most prevalent infectious disease in the world, presenting significant public health challenges and socio-economic consequences.
Small protein may have big role in making more bone and less fat
A small protein may have a big role in helping you make more bone and less fat, researchers say.
Researchers link early stem cell mutation to autism
In a breakthrough scientific study published today in the Proceedings of the National Academy of Sciences, scientists at the Burnham Institute for Medical Research have shown that neural stem cell development may be linked to Autism.
Nerve cells derived from stem cells and transplanted into mice may lead to improved brain treatments
Scientists at the Burnham Institute for Medical Research have, for the first time, genetically programmed embryonic stem (ES) cells to become nerve cells when transplanted into the brain, according to a study published today in The Journal of Neuroscience.
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