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Elastic interactions of membrane proteins
May 04, 2007Cellular survival relies crucially on the ability to receive and communicate signals from and to the outside world. A major part of this regulation and communication is performed by proteins within the membrane of a cell. How these proteins work is an important topic in biology, and one which these scientists have excellently clarified by computational techniques.
Tristan Ursell and colleagues have examined the elasticity of the membrane, which changes thickness to accommodate the proteins embedded within it. Proteins respond to stimuli by altering their shape to perform specific tasks, such as channel proteins, which allow the flow of ions in only one formation. Ursell created a physical model which shows that the membrane itself can communicate structural and hence formational information between membrane proteins. Hence, proteins can "talk" and "respond" to each other using the membrane as a generic "voice."
Public Library of Science
Membrane Proteins Current Events and Membrane Proteins News RSSUniversity of Minnesota invention will help speed development of drug treatments for heart failure
Research conducted by University of Minnesota scientists, in collaboration with Celladon Corporation, has led to the invention of technology to more rapidly identify compounds for the treatment of heart failure.
Small nanoparticles bring big improvement to medical imaging
If you're watching the complex processes in a living cell, it is easy to miss something important-especially if you are watching changes that take a long time to unfold and require high-spatial-resolution imaging.
High-res view of zinc transport protein
How much difference can a tenth of a nanometer make? When it comes to figuring out how proteins work, an improvement in resolution of that miniscule amount can mean the difference between seeing where atoms are and understanding how they interact.
New computer simulation helps explain folding in important cellular protein
Most parts of living organisms come packaged with ribbons. The ribbons are proteins-chains of amino acids that must fold into three-dimensional structures to work properly.
New windows opened on cell-to-cell interactions
Applying biological molecules from cell membranes to the surfaces of artificial materials is opening peepholes on the very basics of cell-to-cell interaction.
Spontaneous Assembly: A New Look at How Proteins Assemble and Organize Themselves into Complex Patterns
Self-assembling and self-organizing systems are the Holy Grails of nanotechnology, but nature has been producing such systems for millions of years.
Intestinal cells surprisingly active in pursuit of nutrition and defense
Every cell lining the small intestine bristles with thousands of tightly packed microvilli that project into the gut lumen, forming a brush border that absorbs nutrients and protects the body from intestinal bacteria.
New nanoparticles could revolutionize therapeutic drug discovery
A revolutionary new protein stabilisation technique has been developed by scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC) which could lead to 30 per cent more proteins being available as potential targets for drug development - opening up exciting possibilities in drug discovery.
Structural biology scores with protein snapshot
In a landmark technical achievement, investigators in the Vanderbilt Center for Structural Biology have used nuclear magnetic resonance (NMR) methods to determine the structure of the largest membrane-spanning protein to date.
'Holy powder' ingredient makes membranes behave for better health
Revered in India as "holy powder," the marigold-colored spice known as turmeric has been used for centuries to treat wounds, infections and other health problems. In recent years, research into the healing powers of turmeric's main ingredient, curcumin, has burgeoned, as its astonishing array of antioxidant, anti-cancer, antibiotic, antiviral and other properties has been revealed.
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The World Acclaims Eternal Protein Man [Explicit] The Membranes (Primary Contributor) |
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ESR Spectroscopy in Membrane Biophysics (Biological Magnetic Resonance) by Marcus A. Hemminga (Author), Lawrence J. Berliner (Author) Spectroscopic methods are not only important as an analytical tool, they also provide information about fundamental physical and chemical properties of molecules, the molecular and electronic structure, and the dynamic behaviour of molecules. Starting from a comprehensive quantum mechanical description, ESR Spectroscopy in Membrane Biophysics introduces the optical (IR, Raman, UV/Vis, CD, fluorescence and laser spectroscopy) and magnetic resonance (1D and 2D-NMR, ESR) techniques. ESR Spectroscopy in Membrane Biophysics is a timely review of the increasing interest in using spin-label ESR as an alternative structural technique for NMR or X-ray diffraction. It is aimed at training an audience to learn ESR spectroscopy to determine membrane protein structures, conformational... |
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"Canine Pancreatic Microsomal Membranes - Protein Expression Systems, Promega - Model PAY4041" by Promega Canine Pancreatic Microsomal Membranes - Protein Expression Systems, Promega - Model PAY4041 : TNT Transcription/Translation Systems: Use for rapid screening and analysis of mutants, protein-protein and protein-DNA interactions, antibody evolution studies, and in vitro expression cloning. Systems are single-tube coupled for translation and transcri |
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