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Simple home spit test to spot deadly pre-eclampsia
May 07, 2007Pre-eclampisa is a potentially fatal condition that kills thousands of babies every year
A simple spit test designed to detect pre-eclampsia in the early stages is being trialed in a UK hospital, reports Cath O'Driscoll in Chemistry & Industry, the magazine of the SCI. The test, which is designed to be used at home, will allow mums-to-be to check for themselves whether they are at risk of the condition, which can be symptomless in the early stages but kills 1000 babies in the UK every year. The test is expected to be more reliable than the traditional blood pressure and urine tests conducted in GPs' offices and hospitals.
Pre-eclampsia is also a leading cause of maternal mortality, killing one woman globally every six seconds, according to the UK's Action on Pre-eclampsia (APEC). Earlier detection and intervention could save lives.
Standard blood pressure and urine tests are unreliable, and there is a lot of scope for "user error", according to Michael Rich, chief executive of APEC. In addition, high blood pressure can be caused by a variety of factors other than pre-eclampsia, and even when a woman develops pre-eclampsia, problems with high blood pressure may not occur until the latter stages.
The new test works by monitoring levels of urate, a salt of uric acid, increased levels of which are thought to be due to impaired kidney excretion in pre-eclampsia.
'A salivary urate test is simple, non-invasive, quick and cheap and can be done at any time. As a metabolic test independent of blood pressure, it may obviate the need for hospital admission,' said retired hospital rheumatologist Brian Owen-Smith, who invented the test.
The trial, which will eventually involve 1000 women, is underway at St Richards Hospital in Chichester. Trial subjects send away saliva-wiped swabs for analysis. Results are expected early next year. The ultimate aim is to develop a "traffic light" detection kit for use in the home.
Pre-eclampsia is thought to be the result of problems relating to the implantation of the placenta. The main diagnostic symptoms are raised blood pressure and the excretion of protein in the urine. While there is no cure, other than the delivery of the baby and removal of the faulty placenta, early detection and management of the problem can have a big impact on patient outcome.
Society of Chemical Industry
Standard blood pressure and urine tests are unreliable, and there is a lot of scope for "user error", according to Michael Rich, chief executive of APEC. In addition, high blood pressure can be caused by a variety of factors other than pre-eclampsia, and even when a woman develops pre-eclampsia, problems with high blood pressure may not occur until the latter stages.
The new test works by monitoring levels of urate, a salt of uric acid, increased levels of which are thought to be due to impaired kidney excretion in pre-eclampsia.
'A salivary urate test is simple, non-invasive, quick and cheap and can be done at any time. As a metabolic test independent of blood pressure, it may obviate the need for hospital admission,' said retired hospital rheumatologist Brian Owen-Smith, who invented the test.
The trial, which will eventually involve 1000 women, is underway at St Richards Hospital in Chichester. Trial subjects send away saliva-wiped swabs for analysis. Results are expected early next year. The ultimate aim is to develop a "traffic light" detection kit for use in the home.
Pre-eclampsia is thought to be the result of problems relating to the implantation of the placenta. The main diagnostic symptoms are raised blood pressure and the excretion of protein in the urine. While there is no cure, other than the delivery of the baby and removal of the faulty placenta, early detection and management of the problem can have a big impact on patient outcome.
Society of Chemical Industry
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Pregnant women risk early delivery from using psychiatric medication
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New link between pre-eclampsia and diet
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Stuff of stink bombs investigated for role in pregnancy
Scientists at the University of Leicester are investigating how the stuff of stink bombs and flatulence could play a critical role in the human reproductive system.
Obesity raises risk of complications in pregnancy, study shows
Expectant mothers who are obese are much more likely to suffer from minor complications such as heart burn and chest infections during pregnancy, a study suggests.
Women with endometriosis need special care during pregnancy to avoid risk of premature birth
The largest study to date of endometriosis in pregnant women has found that the condition is a major risk factor for premature birth.
Ben-Gurion U researchers -- bariatric surgery minimizes pregnancy complications for obese women
Women who undergo bariatric surgery to treat obesity will reduce the risk of medical and obstetric complications when they become pregnant, according to a study by researchers from Ben-Gurion University of the Negev's (BGU) Faculty of Health Sciences.
Pregnancy disorder signals need to screen for heart disease, study shows
High blood pressure experienced during pregnancy could be a woman's earliest warning that she is at risk of developing heart disease - the number one killer of Canadian women - says Queen's University professor of Obstetrics and Gynecology, Graeme Smith.
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