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Simple home spit test to spot deadly pre-eclampsia
May 07, 2007Pre-eclampisa is a potentially fatal condition that kills thousands of babies every year
A simple spit test designed to detect pre-eclampsia in the early stages is being trialed in a UK hospital, reports Cath O'Driscoll in Chemistry & Industry, the magazine of the SCI. The test, which is designed to be used at home, will allow mums-to-be to check for themselves whether they are at risk of the condition, which can be symptomless in the early stages but kills 1000 babies in the UK every year. The test is expected to be more reliable than the traditional blood pressure and urine tests conducted in GPs' offices and hospitals.
Pre-eclampsia is also a leading cause of maternal mortality, killing one woman globally every six seconds, according to the UK's Action on Pre-eclampsia (APEC). Earlier detection and intervention could save lives.
Standard blood pressure and urine tests are unreliable, and there is a lot of scope for "user error", according to Michael Rich, chief executive of APEC. In addition, high blood pressure can be caused by a variety of factors other than pre-eclampsia, and even when a woman develops pre-eclampsia, problems with high blood pressure may not occur until the latter stages.
The new test works by monitoring levels of urate, a salt of uric acid, increased levels of which are thought to be due to impaired kidney excretion in pre-eclampsia.
'A salivary urate test is simple, non-invasive, quick and cheap and can be done at any time. As a metabolic test independent of blood pressure, it may obviate the need for hospital admission,' said retired hospital rheumatologist Brian Owen-Smith, who invented the test.
The trial, which will eventually involve 1000 women, is underway at St Richards Hospital in Chichester. Trial subjects send away saliva-wiped swabs for analysis. Results are expected early next year. The ultimate aim is to develop a "traffic light" detection kit for use in the home.
Pre-eclampsia is thought to be the result of problems relating to the implantation of the placenta. The main diagnostic symptoms are raised blood pressure and the excretion of protein in the urine. While there is no cure, other than the delivery of the baby and removal of the faulty placenta, early detection and management of the problem can have a big impact on patient outcome.
Society of Chemical Industry
Standard blood pressure and urine tests are unreliable, and there is a lot of scope for "user error", according to Michael Rich, chief executive of APEC. In addition, high blood pressure can be caused by a variety of factors other than pre-eclampsia, and even when a woman develops pre-eclampsia, problems with high blood pressure may not occur until the latter stages.
The new test works by monitoring levels of urate, a salt of uric acid, increased levels of which are thought to be due to impaired kidney excretion in pre-eclampsia.
'A salivary urate test is simple, non-invasive, quick and cheap and can be done at any time. As a metabolic test independent of blood pressure, it may obviate the need for hospital admission,' said retired hospital rheumatologist Brian Owen-Smith, who invented the test.
The trial, which will eventually involve 1000 women, is underway at St Richards Hospital in Chichester. Trial subjects send away saliva-wiped swabs for analysis. Results are expected early next year. The ultimate aim is to develop a "traffic light" detection kit for use in the home.
Pre-eclampsia is thought to be the result of problems relating to the implantation of the placenta. The main diagnostic symptoms are raised blood pressure and the excretion of protein in the urine. While there is no cure, other than the delivery of the baby and removal of the faulty placenta, early detection and management of the problem can have a big impact on patient outcome.
Society of Chemical Industry
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Pregnancy disorder signals need to screen for heart disease, study shows
High blood pressure experienced during pregnancy could be a woman's earliest warning that she is at risk of developing heart disease - the number one killer of Canadian women - says Queen's University professor of Obstetrics and Gynecology, Graeme Smith.
New research on pre-eclampsia in mice may have important implications for humans
In a new March of Dimes-funded study of pre-eclampsia, a serious and potentially deadly disorder that affects about 5 percent of pregnancies, researchers have found results in mice that may have important implications for diagnosis and treatment in humans.
Clues to ancestral origin of placenta emerge in Stanford study
Researchers at the Stanford University School of Medicine have uncovered the first clues about the ancient origins of a mother's intricate lifeline to her unborn baby, the placenta, which delivers oxygen and nutrients critical to the baby's health.
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Pre-eclampsia: Etiology and Clinical Practice by Fiona Lyall (Editor), Michael Belfort (Editor) Pre-eclampsia is one of the leading causes of death and disability in mothers and babies. Over four million women worldwide will develop the disorder every year. This book, written by an international team of experts, focuses on both the scientific basis of pre-eclampsia and its management. The basic science section contains up-to-date reviews of the most exciting research developments in pre-eclampsia. The clinical chapters provide a comprehensive review of the pertinent literature, highlighting recent data and new ideas or developments in current management. There is a section in each chapter (where relevant) that deals with practical management, giving clinicians a formulated treatment plan that they can implement directly. The book will be of interest to all professionals interested... |
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Baby Nathan by Denise Davis (Author) Denise Davis, MSW, LSW, was born in Hammond, Indiana, in 1972. She was raised by a single mother since the age of ten when her father died in a tragic accident. Focusing on her academics, she worked hard during her school years and earned a master’s degree in social work from Loyola University in 2002. She currently works in Merrillville, Indiana, providing psychotherapy to children and adolescents. She is a wife and mother of four children, one of which was a stillborn twin named Nathan. This is Nathan’s story, how his short life and death sent Denise on the most challenging journey of her life. |
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Pre-eclampsia: Webster's Timeline History, 1951 - 2007 by Icon Group International (Author) Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Pre-eclampsia," including when used in literature (e.g. all authors that might have Pre-eclampsia in their name). As such, this book represents the largest compilation of timeline events associated with Pre-eclampsia when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the arts, social... |
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