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Protocol for treatment of sepsis can reduce hospital deaths
May 16, 2007More than 215,000 people will die of sepsis in the United States each year, more than 750,000 will require hospital treatment, and the costs will be nearly $17 billion. Severe sepsis is one of the top 10 leading causes of death in adults, yet there has been little progress in recent decades in treating sepsis and septic shock, and the mortality rate remains disturbingly high.
In a paper to be presented at the 2007 Society for Academic Emergency Medicine (SAEM) Annual Meeting, Alan Jones, MD, of Carolinas Medical Center, Charlotte, NC, will show that Early Goal Directed Therapy (EGDT) is clinically effective in reducing hospital mortality when implemented as a routine protocol in Emergency Departments. For 156 patients, 79 receiving standard care at attending physician discretion and 77 receiving the EGDT protocol, 27% of the standard care patients died in the hospital versus 18% of the EGDT patients, a 33% relative decrease in mortality. EGDT patients did spend 2 more days in intensive care and 1 more day in the hospital that standard care patients.
The presentation is entitled "Clinical Effectiveness of Implementing Early Goal Directed Therapy in the Emergency Department Care of Severe Sepsis and Septic Shock: A Prospective Study" by Alan Jones, MD. This paper will be presented at the 2007 SAEM Annual Meeting, May 16-19, 2007, Chicago, IL on Saturday, May 19th, in the Critical Care Session beginning at 1:00 PM in River Exhibition Halls A & B of the Sheraton Chicago Hotel & Towers. Abstracts of the papers presented are published in Volume 14, Issue 5S, the May 2007 supplement of the official journal of the SAEM, Academic Emergency Medicine.
Elsevier Health Sciences
Sepsis Current Events and Sepsis News RSSA Second Skin
Despite advances in treatment regimens and the best efforts of nurses and doctors, about 70% of all people with severe burns die from related infections.
Progress made on group B streptococcus vaccine
Scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have completed a Phase II clinical study that indicates a vaccine to prevent Group B Streptococcus (GBS) infection is possible.
Canadian scientists link fat hormone to death from potentially deadly blood infection
A new Canadian study has found that lower-than-normal levels of a naturally-occurring fat hormone may increase the risk of death from sepsis-an overwhelming infection of the blood which claims thousands of lives each year.
OMRF scientists discover promising new path for treating traumas
A discovery by scientists at the Oklahoma Medical Research Foundation could help save lives threatened by traumatic injuries like those sustained in car crashes or on the battlefield. The work also holds potential for treating severe infectious diseases and diabetes.
Scientists create NICE solution to pneumonia vaccine testing problems
Medical clinics the world over could benefit from new software* created at the National Institute of Standards and Technology (NIST), where a team of scientists has found a way to improve the efficiency of a pneumonia vaccine testing method developed at the University of Alabama at Birmingham (UAB).
Compound shows potential for slowing progression of ALS
A chemical cousin of a drug currently used to treat sepsis dramatically slows the progression of amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig's disease, in mice.
Review: Pneumococcal conjugate vaccines effective at preventing child deaths
A study published in The Cochrane Review this month concludes that pneumococcal conjugate vaccines (PCV), already known to prevent invasive pneumococcal disease (IPD) and x-ray defined pneumonia, was also effective against child deaths.
Key feature of immune system survived in humans, other primates for 60 million years
A new study has concluded that one key part of the immune system, the ability of vitamin D to regulate anti-bactericidal proteins, is so important that is has been conserved through almost 60 million years of evolution and is shared only by primates, including humans - but no other known animal species.
Discovery may lead to powerful new therapy for asthma
University of Texas Medical Branch at Galveston researchers have found that a single enzyme is apparently critical to most allergen-provoked asthma attacks - and that activity of the enzyme, known as aldose reductase, can be significantly reduced by compounds that have already undergone clinical trials as treatments for complications of diabetes.
Abnormal Brain Circuits May Prevent Movement Disorder
Most people who carry a genetic mutation for a movement disorder called dystonia will never develop symptoms, a phenomenon that has puzzled scientists since the first genetic mutation was identified in the 1990's.
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