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House dust may protect against allergic disease early in life
May 21, 2007Endotoxin, a toxic substance made by certain types of bacteria, may reduce the risk of developing the allergic skin condition eczema or wheezing in children if they are exposed to it up to age 3, suggests a study presented at the American Thoracic Society 2007 International Conference, on Sunday, May 20.
Endotoxin is a part of the cell wall of gram-negative bacteria, a type of bacteria that often causes disease. Endotoxin is released when the bacteria dies or is damaged. The new study found that the lower the amount of endotoxin in young children's homes, the more likely they were to have wheezing or eczema by age 3. The higher the amount of endotoxin in their homes, the less likely they were to develop either condition by age 3.
"We're trying to find why children exposed to endoxotin have lower levels of disease early in life," says researcher Melisa Celaya, M.A., of the Arizona Respiratory Center in Tucson.
Celaya found that certain environmental factors increased the levels of endotoxin in a home: having a home older than 30 years, substandard home conditions, carpeting, a musty smell and interior wall leaks were all associated with higher levels of endotoxin.
Blood samples were taken from 484 children enrolled in the Infant Immune Study at different ages, up to 5 years of age. "We will be looking at the relationship between endotoxin levels in the home and chemicals (called cytokines) that are produced by certain immune system cells, to see why children exposed to lower levels are developing more allergic symptoms later on," she says. "This study is unusual in that we are following children over a long period, and are looking at both environmental factors and immunological factors, so we can correlate the two."
The researchers also plan to study whether genetic predisposition changes a child's responses to environmental triggers.
American Thoracic Society
Celaya found that certain environmental factors increased the levels of endotoxin in a home: having a home older than 30 years, substandard home conditions, carpeting, a musty smell and interior wall leaks were all associated with higher levels of endotoxin.
Blood samples were taken from 484 children enrolled in the Infant Immune Study at different ages, up to 5 years of age. "We will be looking at the relationship between endotoxin levels in the home and chemicals (called cytokines) that are produced by certain immune system cells, to see why children exposed to lower levels are developing more allergic symptoms later on," she says. "This study is unusual in that we are following children over a long period, and are looking at both environmental factors and immunological factors, so we can correlate the two."
The researchers also plan to study whether genetic predisposition changes a child's responses to environmental triggers.
American Thoracic Society
Endotoxin Current Events and Endotoxin News RSSIs endotoxin receptor CD14 rs2569190/C-159T gene correlated with chronic hepatitis C?
It is still unknown why the natural history of chronic disease caused by hepatitis C virus (HCV), which currently infects 3% of the world's population, varies from mild in some patients to rapidly progressing in others.
Cell transplantation and diabetes: New sites, new devices
Early attempts at islet cell transplantation to treat diabetes date to the nineteenth century, decades before the discovery of insulin in the 1930s.
What is the role of interleukin-10 in ischemia-reperfusion injury?
I/R injury of the small intestine is consequently a critical problem that is important. DHP-PMX therapy can remove circulating endotoxins and reduce various cytokines, even in patients with high levels of plasma cytokines.
Is the intestinal mucosa barrier malfunction involved in non-alcoholic steatohepatitis?
The pathogenesis of NASH remains unclear. Nowadays, lipid metabolism abnormality, insulin resistance and oxidative stress and lipid peroxidation reaction are thought to place an important role in the pathogenesis of NASH.
Scripps scientists studying sepsis in mice find potential drug targets for deadly disease
"We have identified a key connection of signaling pathways in the cascade of events leading to sepsis. This defines a crucial point where the immune system spirals out of control to cause severe sepsis and where there is an opportunity for therapeutic intervention," says Scripps Research Professor Wolfram Ruf, who led the research with his postdoctoral fellow Frank Niessen.
Who is the arch-criminal in the development of hepatopulmonary syndrome?
The hepatopulmonary syndrome (HPS) develops when an arterial oxygenation deficiency occurs due to intra-pulmonary vascular dilatations that are often associated with severe hepatic disease. HPS occurs in 15-20% of patients with liver cirrhosis undergoing evaluation for orthotopic liver transplantation.
Blood stem cells fight invaders, study finds
No other stem cell is more thoroughly understood than the blood, or hematopoietic, stem cell.
Large dose dexamethasone plays important roles in severe acute pancreatitis
Severe acute pancreatitis (SAP) is a fatal systemic disease featuring acute onset, serious conditions, high incidence of complications and 20 - 30% mortality, mainly due to multiple organ failure at its early stage.
Liver fibrosis will be treated by a potential target
The outcome of hepatitis is either self recovery or its development into liver fibrosis or, further, liver cirrhosis. Liver fibrosis is the early pathological process of cirrhosis, which is considered a reversible, wound-healing response. Since no ideal drug is available for its therapy, liver fibrosis is currently considered to be a major worldwide health problem.
Ozone shuts down early immune response in lungs and body
As policy makers debate what levels of ozone in the air are safe for humans to breathe, studies in mice are revealing that the inhaled pollutant impairs the body's first line of defense, making it more susceptible to subsequent foreign invaders, such as bacteria.
More Endotoxin Current Events and Endotoxin News Articles
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Endotoxins: Pyrogens, LAL Testing and Depyrogenation, Third Edition (Drugs and the Pharmaceutical Sciences) by Kevin L. Williams (Editor) This source expertly examines the discovery, biological structure, control, and continued clarification of endotoxin from a parenteral manufacturing perspective, with in-depth discussion of state-of-the-art technologies involving Limulus amebocyte lysate (LAL) such as assay development, automation, depyrogenation. Completely revised and expanded, this Third Edition contains the knowledge necessary to apply endotoxin testing in the increasingly complex pharmaceutical environment, featuring sections detailing the latest information regarding clinical advances, regulation standards, and validation procedures for computerized kinetic tests. |
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"Luciferin-EF Endotoxin-Free Luciferin Na, Promega - Size 25 mg - Each (25 MG)" by Promega Luciferin-EF Endotoxin-Free Luciferin Na, Promega - Size 25 mg - Each (25 MG) : An endotoxin-free beetle luciferin that can be used for imaging applications where endotoxins may create problems in vivo. Tested to ensure endotoxins are below detection limits. Packaged in amber vials with septa to facilitate easy dilution and use. Store at -70 degrees C (-94 degrees F). |
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DiaGel Kitten 0.5cc Syringe (Pink) by Van Beek Naturals Science Primary Use: DiaGel is an orally administered product which may aid in controlling bacterial diarrhea. DiaGel eliminates bacteria such as E. coli and Salmonella which occur naturally in the GI tract. Secondary Use: DiaGel may be used in conjunction with fluid therapy, endotoxin therapy, or antibiotics to treat secondary infections associated with other causes of diarrhea. Pre-Stress Use: DiaGel may be administered 2 hours prior to stress-induced events (boarding, breeding, traveling, and showing) to help reduce the incidence of diarrhea. |
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Microbial Toxins, Vol. 4: Bacterial Endotoxins by Samuel J. Ajl (Editor) | |
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Bacterial Endotoxins: Cytokine Mediators and New Therapies for Sepsis (Progress in Clinical & Biological Research) by Augueste Sturk (Author), etc. (Author) This volume aims to provide a comprehensive overview of the latest progress in the field of endotoxin research. It describes potential treatment modalities for endotoxin-related septic disorders. | |
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Microbial Toxins Volume V: Bacterial Endotoxins. by Solomon et al. (eds). Kadis (Author) | |
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Clinical Aspects of Endotoxin Shock: Handbook of Endotoxin by R. A. Proctor (Editor) | |
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Endotoxin-Induced: Webster's Timeline History, 1966 - 2007 by Icon Group International (Author) Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Endotoxin-Induced," including when used in literature (e.g. all authors that might have Endotoxin-Induced in their name). As such, this book represents the largest compilation of timeline events associated with Endotoxin-Induced when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the... |
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Endotoxin and Sepsis: Molecular Mechanisms of Pathogenesis, Host Resistance, and Therapy (Progress in Clinical and Biological Research) by Jack Levin (Editor), Matthew Pollack (Editor), Takashi Yokochi (Editor), Masayasu Nakano (Editor) Progress in Clinical and Biological Research, Volume 397 ENDOTOXIN AND SEPSIS Molecular Mechanisms of Pathogenesis, Host Resistance, and Therapy Proceedings of the Fourth Conference of the International Endotoxin Society Held in Nagoya, Japan, October 23-27, 1996 Jack Levin, Matthew Pollack, Takashi Yokochi, and Masayasu Nakano, Editors Recent breakthroughs in our understanding of the molecular biology of the human immune response have lead to important advances in the recognition and treatment of sepsis. Endotoxin and Sepsis: Molecular Mechanisms of Pathogenesis, Host Resistance, and Therapy compiles the latest basic and clinical research on many aspects of sepsis, including sepsis/SIRS. It provides researchers and clinicians with an up-to-date overview of the critical data... |
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Endotoxin and the Lungs (Lung Biology in Health and Disease) by Kenneth Brigham (Editor) Vanderbilt University, Nashville, Tennessee. Advanced clinical research on endotoxin pathobiology, and on current and experimental treatment of endotoxin-induced lung injury. For respiratory and critical care physicians. 48 contributors, 41 U.S. |
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