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Retinol lotion reduces the fine wrinkles from natural aging of skin
May 22, 2007Products previously were thought only to improve skin aged by sun
ANN ARBOR, Mich. - Lotions containing retinol improve the appearance of skin that has become wrinkled through the normal aging process, not just skin that has been damaged by exposure to the sun, according to a new study from the University of Michigan Health System.
Researchers tested lotions containing retinol - Vitamin A that is found in many skin-care products - on the skin of elderly patients. Lotion containing retinol was used on one arm of each participant, while a lotion without retinol was applied to the other arm.
Wrinkles, roughness and overall aging severity were all significantly reduced in the retinol-treated arm compared with the control arm, according to the study, which appears in the May issue of the journal Archives of Dermatology. The production of collagen, due to the retinol treatment, also makes it more likely that the skin can withstand injury and ulcer formation, researchers say.
"With the population aging so rapidly, it is important that we find ways of treating skin conditions of elderly people - not just for purposes of vanity, but also for the healing of wounds and the reduction of ulcers," says senior author Sewon Kang, M.D., professor of dermatology at the U-M Medical School.
This research serves as an important step forward in the understanding of how aging skin can be improved, researchers say.
"In the past, it was everyone believed that retinoids would treat only photoaging, or damage from exposure to sun. This is the first systematic, double-blind study showing that it improves any kind of aging - photoaging as well as natural aging," says co-author John J. Voorhees, M.D., the Duncan and Ella Poth Distinguished Professor and chair of the Department of Dermatology at the U-M Medical School. "You can rub it anywhere, and it will help to treat the signs of aging."
The lotion was made at U-M, but U-M will not commercialize this lotion because it was designed only for experimental purposes and, therefore, is cosmetically undesirable. Many retinol containing cosmeceutical creams, however, are sold by various companies. Those specific products were not tested by the U-M team.
The reduction of wrinkles in the study's participants was due to increased collagen production and a significant induction of glycosaminoglycans, which are known to retain large quantities of water. In general, aging skin tends to be thinner, laxer and more prone to fine wrinkles than young skin.
University of Michigan Health System
Wrinkles, roughness and overall aging severity were all significantly reduced in the retinol-treated arm compared with the control arm, according to the study, which appears in the May issue of the journal Archives of Dermatology. The production of collagen, due to the retinol treatment, also makes it more likely that the skin can withstand injury and ulcer formation, researchers say.
"With the population aging so rapidly, it is important that we find ways of treating skin conditions of elderly people - not just for purposes of vanity, but also for the healing of wounds and the reduction of ulcers," says senior author Sewon Kang, M.D., professor of dermatology at the U-M Medical School.
This research serves as an important step forward in the understanding of how aging skin can be improved, researchers say.
"In the past, it was everyone believed that retinoids would treat only photoaging, or damage from exposure to sun. This is the first systematic, double-blind study showing that it improves any kind of aging - photoaging as well as natural aging," says co-author John J. Voorhees, M.D., the Duncan and Ella Poth Distinguished Professor and chair of the Department of Dermatology at the U-M Medical School. "You can rub it anywhere, and it will help to treat the signs of aging."
The lotion was made at U-M, but U-M will not commercialize this lotion because it was designed only for experimental purposes and, therefore, is cosmetically undesirable. Many retinol containing cosmeceutical creams, however, are sold by various companies. Those specific products were not tested by the U-M team.
The reduction of wrinkles in the study's participants was due to increased collagen production and a significant induction of glycosaminoglycans, which are known to retain large quantities of water. In general, aging skin tends to be thinner, laxer and more prone to fine wrinkles than young skin.
University of Michigan Health System
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Embryology Study Offers Clues to Birth Defects
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Golden rice an effective source of vitamin A
The beta-carotene in so-called "Golden Rice" converts to vitamin A in humans, according to researchers at Baylor College of Medicine (www.bcm.edu) and Tufts University in an article that appears in the current issue of the American Journal of Clinical Nutrition.
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Good news for a fast-wrinkling generation: Some anti-aging methods work
Fine wrinkles, deeper creases, saggy areas around the mouth and neck - the sights in the mirror that make baby boomers wince - are not inevitable. They result from a structural breakdown inside the skin that some existing treatments effectively counteract by stimulating the growth of new, youthful collagen, University of Michigan scientists say.
Rutgers Researchers Unlock Mysteries of Vitamin A Metabolism During Embryonic Development
Researchers at Rutgers have unlocked some of the mysteries of how the developing embryo reacts to fluctuations in the amount of vitamin A present in the maternal blood stream. Their results are presented in the February 28 issue of the Journal of Biological Chemistry.
UAB research could improve the prognosis and treatment of lung cancer
A group of scientists led by Professor Xavier Parés of the Department of Biochemistry and Molecular Biology at Universitat Autònoma de Barcelona, has published a research on AKR1B10, an enzyme that is detected in large quantities only in lung cancers, particularly those caused by smoking.
Topical retinol helps reduce wrinkles associated with natural skin aging
Applying vitamin A to the skin appears to improve the wrinkles associated with natural aging and may help to promote the production of skin-building compounds.
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