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454 Life Sciences and Baylor College of Medicine complete sequencing of DNA pioneer
June 01, 2007454 Life Sciences Corporation, in collaboration with scientists at the Human Genome Sequencing Center, Baylor College of Medicine, announced today in Houston, Texas, the completion of a project to sequence the genome of James D. Watson, Ph.D., co-discoverer of the double-helix structure of DNA. The mapping of Dr. Watson's genome was completed using the Genome Sequencer FLX™ system and marks the first individual genome to be sequenced for less than $1 million.
"When we began the Human Genome Project, we anticipated it would take 15 years to sequence the 3 billion base pairs and identify all the genes," said Richard Gibbs, Ph.D. , director, Human Genome Sequencing Center, Baylor College of Medicine. "We completed it in 13 years in 2003 - coinciding with the 50th anniversary of the publication of the work of Watson and Dr. Francis Crick that described the double helix. Today, we give James Watson a DVD containing his personal genome - a project completed in only two months. It demonstrates how far sequencing technology has come in a short time."
Christopher McLeod, president and CEO of 454 Life Sciences, added: "The sequencing of Dr. Watson's genome validates the approach taken by 454 Life Sciences in developing a technology to make the sequencing of individual human genomes quick and affordable. As we take another step on the path toward the X-Prize and reducing the cost of human genome sequencing to $10,000, we hope to enable a new era of medicine that is tailored to a patient's unique genetic profile."
Michael Egholm, Ph.D., vice president of research and development of 454 Life Sciences, said: "The sequencing of Dr. Watson's genome has been done on production Genome Sequencer FLX™ systems, where we could take advantage of the instrument's high quality data and long read lengths. Using the unbiased 454 Sequencing™ technology, we obtained a near complete picture of Dr. Watson's genome and were able to identify missing pieces of the public reference genome generated by the Human Genome Project. By making his genome publicly available, Dr. Watson will provide a tremendous resource to researchers and future generations."
Dr. Watson will receive a DVD with his genomic sequence. He will decide which of his data will be published.
"When I conceived the 454 Sequencing™ technology, I envisioned making routine individual genome sequencing a reality to help with personal medical care," said Jonathan Rothberg, founder and former chairman of 454 Life Sciences. "Since Dr. Watson is the co-discoverer of DNA's structure and 1962 Nobel Laureate, it is only appropriate to work with him on this ambitious genome sequencing project. This project will pave the way for exploring life at the ultimate level by uncovering what makes each individual unique."
Russo Partners, LLC
Michael Egholm, Ph.D., vice president of research and development of 454 Life Sciences, said: "The sequencing of Dr. Watson's genome has been done on production Genome Sequencer FLX™ systems, where we could take advantage of the instrument's high quality data and long read lengths. Using the unbiased 454 Sequencing™ technology, we obtained a near complete picture of Dr. Watson's genome and were able to identify missing pieces of the public reference genome generated by the Human Genome Project. By making his genome publicly available, Dr. Watson will provide a tremendous resource to researchers and future generations."
Dr. Watson will receive a DVD with his genomic sequence. He will decide which of his data will be published.
"When I conceived the 454 Sequencing™ technology, I envisioned making routine individual genome sequencing a reality to help with personal medical care," said Jonathan Rothberg, founder and former chairman of 454 Life Sciences. "Since Dr. Watson is the co-discoverer of DNA's structure and 1962 Nobel Laureate, it is only appropriate to work with him on this ambitious genome sequencing project. This project will pave the way for exploring life at the ultimate level by uncovering what makes each individual unique."
Russo Partners, LLC
Genome Sequencing Current Events and Genome Sequencing News RSSScientists at UA, collaborating institutions decode maize genome
Scientists from the University of Arizona led by Arizona Genomics Institute director Rod A. Wing and from collaborating institutions have deciphered the complete genetic code of the maize plant for the first time.
UCSD discovery allows scientists for the first time to experimentally annotate genomes
Over the last 20 years, the sequencing of the human genome, along with related organisms, has represented one of the largest scientific endeavors in the history of mankind.
Standards for a new genomic era
A team of geneticists at Los Alamos National Laboratory, together with a consortium of international researchers, has recently proposed a set of standards designed to elucidate the quality of publicly available genetic sequencing information.
Establishing standard definitions for genome sequences
In 1996, researchers from major genome sequencing centers around the world convened on the island of Bermuda and defined a finished genome as a gapless sequence with a nucleotide error rate of one or less in 10,000 bases.
Draft potato genome based on unique potato variety
The Potato Genome Sequencing Consortium (PGSC), an international team of scientists from industry and academia in 14 countries, has released a draft sequence of the potato genome with the help of a Virginia Tech researcher.
MSU scientist helps map potato genome; move will improve crop yield
It's been cultivated for at least 7,000 years and spread from South America to grow on every continent except Antarctica. Now the humble potato has had its genome sequenced.
Study of huge numbers of genetic mutations point to oxidative stress as underlying cause
A study that tracked genetic mutations through the human equivalent of about 5,000 years has demonstrated for the first time that oxidative DNA damage is a primary cause of the process of mutation - the fuel for evolution but also a leading cause of aging, cancer and other diseases.
Faster, cheaper way to find disease genes in human genome passes initial test
University of Washington (UW) researchers have successfully developed a novel genome-analysis strategy for more rapid, lower cost discovery of possible gene-disease links.
CSHL scientists harness logic of 'Sudoku' math puzzle to vastly enhance genome-sequencing capability
A math-based game that has taken the world by storm with its ability to delight and puzzle may now be poised to revolutionize the fast-changing world of genome sequencing and the field of medical genetics.
Aluminum-oxide nanopore beats other materials for DNA analysis
Fast and affordable genome sequencing has moved a step closer with a new solid-state nanopore sensor being developed by researchers at the University of Illinois.
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