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Combination therapy reduces tumor resistance to radiation
June 08, 2007Radiation is used to treat a variety of tumors and the response of tumors to radiation is dependent on endothelial cell death, which in turn limits oxygen delivery to the tumor, causing hypoxia and tumor cell death. Recently, radiation-induced hypoxia was shown to trigger tumor resistance to radiation via the activation of new blood vessel formation (angiogenesis) through molecules known as HIF-1-regulated cytokines. In a study appearing online on June 7 in advance of publication in the July print issue of the Journal of Clinical Investigation, Claire Magnon and colleagues from Institut Gustave Roussy, France, show that a combination of radiation treatment and the use of angiogenesis inhibitors such as canstatin is able to overcome HIF-1-dependent tumor survival pathways and increases tumor cell death. The authors found that following application of this dual therapy to mice, HIF-1alpha increased the activity of the canstatin-induced tumor apoptotic pathway, which lead to lethal tumor damage. The study demonstrates a crucial role for angiogenesis inhibitors in shifting tumor radioresistance towards tumor apoptosis and suggests that a combination of radiation and angiogenesis inhibitors could potentially be used to overcome HIF-1-dependent tumor radioresistance.
Journal of Clinical Investigation
Angiogenesis Current Events and Angiogenesis News RSSPazopanib shrinks lung cancers before surgery
Pazopanib, a new oral angiogenesis inhibitor, has demonstrated interesting activity in difficult to treat non-small-cell lung cancer, US researchers report.
Joining forces against cancer
In cancer therapy, the best results are often achieved by combining treatments such as chemotherapy, radiotherapy and surgery.
Gap junction protein vital to successful pregnancy, researchers find
Researchers studying a critical stage of pregnancy - implantation of the embryo in the uterus - have found a protein that is vital to the growth of new blood vessels that sustain the embryo. Without this protein, which is produced in higher quantities in the presence of estrogen, the embryo is unlikely to survive.
Angiotensin inhibitors and receptor blockers linked to lower risk of nonmelanoma skin cancer
The use of angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) was associated with a reduced risk of basal cell or squamous cell skin cancers in U.S. veterans, researchers report in the August 26 online issue of the Journal of the National Cancer Institute.
Normalizing tumor vessels to improve cancer therapy
Chemotherapy drugs often never reach the tumors they're intended to treat, and radiation therapy is not always effective, because the blood vessels feeding the tumors are abnormal-"leaky and twisty" in the words of the late Judah Folkman, MD, founder of the Vascular Biology program at Children's Hospital Boston.
Cancer therapy: A role for MAPK inhibitors combined with mTORC1 inhibitors
Nearly a decade ago, while it was being tested as an immunosuppressive agent to prevent organ rejection in transplant patients, the drug rapamycin was also discovered to have anti-tumor properties. Since then, several rapamycin analogs known as mTOR (mammalian target of rapamycin) inhibitors have been tested in clinical trials for the treatment of various types of cancer.
Drugs to inhibit blood vessel growth show promise in rat model of deadly brain tumor
In a landmark study, Medical College of Wisconsin researchers in Milwaukee report that drugs used to inhibit a specific fatty acid in rat brains with glioblastoma-like tumors not only reduced new blood vessel growth and tumor size dramatically, but also prolonged survival. The study is the featured cover story of the August, 2008 Journal of Cerebral Blood Flow & Metabolism.
Gladstone scientists identify single microRNA that controls blood vessel development
Scientists from the Gladstone Institute of Cardiovascular Disease (GICD) and UCSF have identified a key regulatory factor that controls development of the human vascular system, the extensive network of arteries, veins, and capillaries that allow blood to reach all tissues and organs.
Vitamin A pushes breast cancer to form blood vessel cells
Researchers at Georgetown University Medical Center have discovered that vitamin A, when applied to breast cancer cells, turns on genes that can push stem cells embedded in a tumor to morph into endothelial cells. These cells can then build blood vessels to link up to the body's blood supply, promoting further tumor growth.
New oral angiogenesis inhibitor offers potential nontoxic therapy for a wide range of cancers
The first oral, broad-spectrum angiogenesis inhibitor, specially formulated through nanotechnology, shows promising anticancer results in mice, report researchers from Children's Hospital Boston.
More Angiogenesis Current Events and Angiogenesis News Articles
 | Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy Tumor angiogenesis is one of the most prominent mechanisms driving tumor development and progression. In the past 30 years some of the most important signaling pathways linking specific angiogenic activities of tumor cells to fatal reactions of the patient s vascular system have been elucidated. Crucial targets for therapeutic intervention have been identified and validated. Based on these... |
 | Angiogenesis: An Integrative Approach from Science to Medicine Dr. Judah Folkman, father of angiogenesis , (1933-2008) was the Director of the Vascular Biology Program, Andrus Professor of Pediatric Surgery, and Professor of Cell Biology at Harvard University's Boston Children's Hospital. In the 1971 issue of The New England Journal of Medicine, he proposed the theory that tumor growth is angiogenesis dependent. This premise was the basis of this field of... |
 | Modern Concepts in Angiogenesis This volume addresses current emerging concepts in the field of angiogenesis, including important angiogenesis modifiers which are essential in combination with growth factors (VEGF and FGF) for the physiological process and also for therapeutic applications. It covers many of the lesser discussed areas including blood vessel growth guidance (interactions with CNS) as well as emerging practical... |
 | Retinal and Choroidal Angiogenesis Retinal and choroidal angiogenesis are the leading causes of irreversible vision loss in developed countries. For this reason, ocular angiogenesis is an intensely studied process, and the field is advancing at an astounding pace. It has become increasingly difficult to manage the vast amount of information generated by the growing group of interested investigators, thus a resource is needed that... |
 | DR. FOLKMAN'S WAR: ANGIOGENESIS AND THE STRUGGLE TO DEFEAT CANCER by ROBERT COOKE |
 | New Frontiers in Angiogenesis New Frontiers in Angiogenesis is a fresh and unconventional look at the field of angiogenesis. It focuses on provocative and cutting-edge topics in the field of angiogenesis. Each chapter will take the reader along on a journey into uncharted territories of angiogenesis. The volume starts with a comprehensive overview of the field and continues with topics that have been minimally explored. The... |
 | Angiogenesis: Models, Modulators, and Clinical Applications Univ. of Patras, Greece.... |
 | Angiogenesis in and Disease: Basic Mechanisms and Clinical Applications by Gabor Rubanyi Outlines strategies for stimulating capillary formation in hypoxia and ischemia and inhibiting it in cancer, diabetes, and chronic inflammation. This state-of-the-science reference highlights recent progress in the ways to promote formation of new blood vessels in ischemic/hypoxic tissue and the means to stifle capillary growth and development in solid tumors, diabetic retinopathy, and chronic... |
 | Angiogenesis in Brain Tumors (Cancer Treatment and Research) The mutual relationship between tumor growth and concomitant neovascularization offers important insight into the biology of brain tumors and the development of new treatment strategies. Many of the early findings in the biology of angiogenesis have been investigated using brain tumor models. Angiogenesis in Brain Tumors is part of the Cancer Treatment and Research book series and this volume... |
 | Angiogenesis Assays: A Critical Appraisal of Current Techniques Angiogenesis Assays: A Critical Appraisal of Current Techniques describes in detail the in vitro and in vivo assays currently being used to study angiogenesis, including the provision of protocols. The chapters are written by leading scientists who use these techniques in their angiogenesis research programs and who deliver here a critical appraisal of their strengths and weaknesses. Divided into... |
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