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Malaria and Epstein-Barr virus linked to pediatric cancer in Africa
June 08, 2007Endemic Burkitt lymphoma is a form of cancer that accounts for up to 74% of malignant disorders in children in equatorial Africa. Malaria and Epstein-Barr virus (EBV) are known cofactors in its development, but to date, their relative contribution has not been well understood. In a new study published online in the open-access journal PLoS Pathogens, researchers at the Karolinska Institutet in Stockholm explain how certain Plasmodium falciparum antigens directly induce Epstein-Barr virus (EBV) reactivation, increasing the risk of Burkitt lymphoma.
EBV is a ubiquitous virus that establishes a lifelong persistence following primary infection. How EBV affects its host hinges on a balance between viral latency, viral replication, and host immune responses. Generally harmless in almost every host and rarely a cause of disease, reactivation of EBV has been causally associated with various cancers. Acute malaria infection is known to increase the level of circulating EBV, but the precise mechanisms through which this virus reactivation occurs had been previously unknown.
Now, Arnaud Chene and colleagues have identified CIDRla as the first microbial protein able to spur a latently EBV-infected cell into active production. Their results suggest that P. falciparum-derived proteins can lead to a direct reactivation of EBV during acute malaria infection, increasing the risk of Burkitt lymphoma development for children living in malaria-endemic areas.
Public Library of Science
Public Library of Science
Pediatric Cancer Current Events and Pediatric Cancer News RSSDevelopmental drug may help bone fractures heal after radiation exposure
A drug currently under development by the University of Pittsburgh School of Medicine may help bone fractures heal more quickly after radiation exposure, according to a study by Pitt researchers.
New research strategy for understanding drug resistance in leukemia
UCSF researchers have developed a new approach to identify specific genes that influence how cancer cells respond to drugs and how they become resistant. This strategy, which involves producing diverse genetic mutations that result in leukemia and associating specific mutations with treatment outcomes, will enable researchers to better understand how drug resistance occurs in leukemia and other cancers, and has important long-term implications for the development of more effective therapies.
PET Can Help Guide Treatment Decisions for a Common Pediatric Cancer
A new study published in the August issue of The Journal of Nuclear Medicine shows that positron emission tomography (PET) is an important tool for depicting the extent of neuroblastoma in some patients, particularly for those in the early stages of the disease.
Genetic finding could lead to targeted therapy for neuroblastoma
Researchers have identified a genetic glitch that could lead to development of neuroblastoma, a deadly form of cancer that typically strikes children under 2.
Robot playmates monitor emotional state of children with ASD
The day that robot playmates help children with autism learn the social skills that they naturally lack has come a step closer with the development of a system that allows a robot to monitor a child's emotional state.
Research to provide information of long-term effects of childhood cancer treatment to parents
Researchers from the neuropsychology department and pediatric hematology/oncology department at Rhode Island Hospital and its Hasbro Children's Hospital have published the results of their findings on parents' needs for information about the neurocognitive late effects (NCLE) of treatment for childhood cancer.
Scripps Florida scientists find novel use for old compound in cancer treatment
The compound, α-difluoromethylornithine or DFMO, targets the activity of a specific enzyme and, even in very limited doses, is effective in protecting against the malignancy in animal models.
Children's cancer group recommends global evaluation system for neuroblastoma to improve treatment
An international coalition of pediatric cancer physicians and researchers has developed new systems to standardize studies of neuroblastomas across the world.
Scientists close in on method to fight deadly childhood cancer
A multicenter team of researchers, including scientists from the University of Florida, has discovered a way to potentially block the growth of neuroblastoma, a type of cancer responsible for 15 percent of all cancer deaths in children.
Novel anticancer strategy moves from laboratory to clinic
Researchers at Emory University have developed a novel anti-tumor compound that represents a distinct strategy: targeting one of the most important "intercept points" for cancer cells.
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Pediatric Oncology (M.D. Anderson Cancer Care Series) by Ka Wah Chan (Editor), R. Beverly Raney Jr. (Editor) The M.D. Anderson Cancer Care series is intended to provide state-of-the art guidelines on the multimodality treatment of cancer (multimodality is defined as any combination of surgery, chemotherapy, radiation), according to the standard of practice at MDACC. Topics covered in this volume will include a spectrum of several different malignancies occurring frequently in children, as well as melanoma, supportive care, and an outline of the Center’s Adolescent and Young Adult Program, a national model. Because of treatment advances, 4 out of 5 children survive cancer today. As in the previous series volumes, each chapter will end with an up-to-date list of suggested readings, as well as "key practice points" highlighting principles and practices of each chapter, for at-a-glance... |
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LIFE / DoLife Sports Cap for Pediatric Cancer Awareness, Reflective Safety Stripes, 3 Embroideries, Ladies Smaller Fit or Child Size by LIFE / DoLife LIFE products are not so much a physical item as they are an expression of a State of Mind. Allow the LIFE symbol help empower you to a positive state of mind. The LIFE awareness cap speaks to the core of any cause...the enjoyment and preservation of Life, with or without cancer. All LIFE products are of excellent quality since I designed the symbol after losing Mom to pancreatic cancer and this is HER symbol. Make a positive and hope-filled statement by using LIFE products and abandon the abused and overused nondescript regular ribbon. LIFE donates 10% of net profits to smaller community charities that really put to work our donations instead of wasting it on advertising for themselves. The LIFE symbol offers: Hope, Optimism, Gratitude, Abundance, Empowerment, Vitality, Energy,... |
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Breast Cancer Ribbon with Purple BG Ultrascope Stethoscope Pediatric by UltraScope UltraScope is a single sided pressure sensitive acoustic stethoscope for complete assessment/diagnosis of heart/lung sounds in human and animal patients. The UltraScope excels in medically challenging situations allowing assessment even in noisy environments and/or through dressings or thick clothing, when access to skin is not possible. What Makes Ultrascope Unique? * Excellent Acoustics Even in Noisy Environments - Hear vitals through sirens, ambulance engines, or crying children. * Superior Performance with Special Needs Patients - UltraScope excels when assessment on skin is not an option. Veterinarians can hear through thick animal fur and purring. * 20% Lighter Weight than the Leading Cardiology Brand * Individually Hand Painted - 15 Tubing Colors - UltraScope is the only hand... |
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Bands Doing Battle: Compilation to Benefit Pediatric Cancer Research and Encourage Bloo by Various Artists | |
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Childhood Cancer: A Handbook from St. Jude Children's Research Hospital by Scientists (Author), St. Jude Clinicians (Author), Joseph Mirro M.D. (Author), Grant Steen Ph.D. (Author), R. Grant Steen (Editor), Joseph Mirro (Editor) From clinicians and scientists at the largest children's cancer research hospital in the U.S., a guide to diagnosing, treating, and surviving childhood cancer Approximately 20,000 new cases of childhood cancer are diagnosed each year. Until now, the families who receive this devastating news have had no one volume to turn to for up-to-date information, clear answers, and authoritative resource recommendations. To meet this need, clinicians and scientists at the world-famous St. Jude Children's Research Hospital have compiled the most comprehensive and compassionate family reference available. From practical matters, such as what tests to expect during diagnosis, treatment options for each kind of cancer, and the value and availability of clinical trials, to the emotional needs of... |
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ABC News UpClose Stewart Goldman When asked about working with oncology patients at Children's Memorial Hospital in Chicago, Dr. Stewart Goldman's honest answer was that it was hard, and sometimes he wasn't sure he wanted to do it for the rest of his life. But for now, the gifts his job gave him far outweighed the sadness that comes from being around children who die. Dr. Goldman answers ABC News' questions about his work and its impact on him and his family. Correspondent: Jim... |
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Unfinished Love: Walking by Faith through Pediatric Cancer by Sherry Tucker (Author) One moment can define your life. One moment can reach into your heart, crush it, trample it and destroy it. Then the moment leaves and in its wake you are left to repair the damage. Suddenly the future path you had painted in your mind evaporates and a new path must be found. When my seven year old son, Zachary, was diagnosed with a cancerous brain tumor in July 2005, he joined more than 10 million other people in the United States living with cancer. My family was thrown into an unforeseen journey that brought us to our knees in pain, heartache and prayer. Unfinished Love A Journey of Faith through Pediatric Cancer chronicles the ten month struggle cancer brought to our lives and the lessons we learned. To the astonishment of many, Zach faced his cancer with unrelenting optimism,... |
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The Lippincott Williams & Wilkins Pain Library [VHS] | |
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LIFE / DoLife Sports Cap for Pediatric Cancer Awareness, Reflective Safety Stripes, 3 Embroideries, Ladies Regular Fit by LIFE / DoLife LIFE products are not so much a physical item as they are an expression of a State of Mind. Allow the LIFE symbol help empower you to a positive state of mind. The LIFE awareness cap speaks to the core of any cause...the enjoyment and preservation of Life, with or without cancer. All LIFE products are of excellent quality since I designed the symbol after losing Mom to pancreatic cancer and this is HER symbol. Make a positive and hope-filled statement by using LIFE products and abandon the abused and overused nondescript regular ribbon. LIFE donates 10% of net profits to smaller community charities that really put to work our donations instead of wasting it on advertising for themselves. The LIFE symbol offers: Hope, Optimism, Gratitude, Abundance, Empowerment, Vitality, Energy,... |
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Breast Cancer Awareness Ribbon Ultrascope Stethoscope Pediatric by UltraScope UltraScope is a single sided pressure sensitive acoustic stethoscope for complete assessment/diagnosis of heart/lung sounds in human and animal patients. The UltraScope excels in medically challenging situations allowing assessment even in noisy environments and/or through dressings or thick clothing, when access to skin is not possible. What Makes Ultrascope Unique? * Excellent Acoustics Even in Noisy Environments - Hear vitals through sirens, ambulance engines, or crying children. * Superior Performance with Special Needs Patients - UltraScope excels when assessment on skin is not an option. Veterinarians can hear through thick animal fur and purring. * 20% Lighter Weight than the Leading Cardiology Brand * Individually Hand Painted - 15 Tubing Colors - UltraScope is the only hand... |
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