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Menthol receptor also important in detecting cold temperatures
June 08, 2007New Haven, Conn.-The ion channel activated by menthol also detects a wide range of cold temperatures and relays the information to the brain, according to a study in Nature by Yale School of Medicine, the University of California at San Francisco (UCSF), and the University of Wisconsin.
The finding solves the mystery of how important the ion channel TRPM8 is for alerting the body to cold temperatures.
"TRPM8 is the primary, if not sole, determinant of thermosensitivity in the cool range," the researchers noted. "It also contributes to the detection of extreme cold, or temperatures below 15 C degrees."
Cold, heat, sound, light, taste, and smell are detected and converted into neural impulses through the activation of receptors, which then propagate the signal by opening an ion channel. Once the channel is open, an electrical impulse travels to other neurons.
In this paper, Sven-Eric Jordt, assistant professor of pharmacology at Yale, and colleagues, found that isolated, cultured nerve cells that express TRPM8 react to cooling stimuli, but cells cultured from mice lacking TRPM8 do not. Also, mice engineered without TRPM8 are much less sensitive to cold than mice with TRPM8.
"TRPM8 does not seem to be the sole receptor responsible for detecting cold," Jordt said. "The TRPM8 knockout mice sensed temperatures below 15 C degrees, which indicates the possible existence of another pathway for detecting extreme cold."
Yale University
Cold, heat, sound, light, taste, and smell are detected and converted into neural impulses through the activation of receptors, which then propagate the signal by opening an ion channel. Once the channel is open, an electrical impulse travels to other neurons.
In this paper, Sven-Eric Jordt, assistant professor of pharmacology at Yale, and colleagues, found that isolated, cultured nerve cells that express TRPM8 react to cooling stimuli, but cells cultured from mice lacking TRPM8 do not. Also, mice engineered without TRPM8 are much less sensitive to cold than mice with TRPM8.
"TRPM8 does not seem to be the sole receptor responsible for detecting cold," Jordt said. "The TRPM8 knockout mice sensed temperatures below 15 C degrees, which indicates the possible existence of another pathway for detecting extreme cold."
Yale University
Menthol Current Events and Menthol News RSSStudy finds that tobacco companies changed design of cigarettes without alerting smokers
As President Obama prepares to sign a bill giving the Food and Drug Administration (FDA) oversight of the tobacco industry, a new study from Harvard School of Public Health (HSPH) researchers shows that tobacco manufacturers have continually changed the ingredients and the design of their cigarettes over time, even if those changes have exceeded acceptable product variance guidelines.
Misuse of Vicks VapoRub may harm infants and toddlers
Vicks® VapoRub®, the popular salve used to relieve symptoms of cough and congestion, may be harmful for infants and toddlers.
Popular cold and cough treatment may create respiratory distress in young children
New research out of Wake Forest University Baptist Medical Center suggests that Vicks® VapoRub®, the popular menthol compound used to relieve symptoms of cough and congestion, may instead create respiratory distress in infants and small children.
Tobacco industry manipulated cigarette menthol content to recruit new smokers among young people
Menthol cigarette brands have been rising in popularity with adolescents, and the highest use has been among younger, newer smokers. Researchers at Harvard School of Public Health (HSPH) explored tobacco industry manipulation of menthol levels in specific brands and found a deliberate strategy to recruit and addict young smokers by adjusting menthol to create a milder experience for the first time smoker.
Dairy, Fruits and Veggies May Help Smokers Quit
Milk does the body good — and may help smokers break the habit, say researchers at Duke University Medical Center.
Swishing once a day with mouthrinse poses no harm to dental work
People have been paying more attention to the effects certain liquids like coffee, citrus-containing drinks, and even toothbrushes have on teeth. Mouthrinses are no exception.
Study suggests menthol cigarette smokers may have more difficulty quitting smoking
Menthol and non-menthol cigarettes appear to be equally harmful to the arteries and to lung function, but smokers of menthols may be less likely to attempt or succeed at quitting.
Tobacco industry deceived public with 'low tar' cigarettes
The tobacco industry has deliberately deceived the public with "low tar/light" cigarettes, reveals an analysis in a special supplement to Tobacco Control. Industry documents show that companies recognised that low tar products were as dangerous as regular cigarettes, yet marketed them as healthy alternatives.
Fresh zing to food and drink with the minty flavour
It`s 35 times fresher than mint yet tastes of absolutely nothing GET ready to chill out with the world`s coolest drinks. The secret? A natural food additive with 35 times the cooling power of menthol-but no minty flavour whatsoever. It could bring a supercool fresh tang to a wide range of products, including beer, bottled water, citrus drinks, chocolate and confectionery, says Thomas Hofmann, whose team at the German Research Centre for Food Chemistry in Garching, Munich, discovered the new substance. And because it "cools" skin 250 times as intensely as mint, they say it could add fresh zest to cosmetics such as anti-perspirants.
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Menthol Crystals, 1/2 lb. - Bulk by Frontier Natural Brands Menthol, the major constituent of Peppermint Oil, is one of the main ingredients in Peppermint. It looks like a rock crystal when isolated. It is obtained from various species of Mentha. It has a strong odor of peppermint, and a warm aromatic taste followed by a sensation of cold on drawing air into the mouth. Menthol's refreshing aroma and cooling action, along with its stimulant and anti-septic qualities have led to its widespread use for medicinal purposes in pharmaceuticals and cosmetics. A menthol inhalation is the best way to clear the sinuses and relieve the stuffiness and headaches associated with catarrh. 0-89836-02709-2 NOTE: Most Frontier Packaged Herbs & Spice products (bagged) come in 16 oz. bags unless specified otherwise. If unsure, please email Customer Service... |
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Vapor-Eze Universal Refill Kit - Menthol Eucalyptus Oil and 15 Blank Pads (Works with Vapor-Eze Item 1070 and 5000) (Pack of 2) by Vapor-eze This Universal Waterless Vaporizer Refill Kit contains pure Menthol & Eucalyptus Oil and 15 cotton pads. Combines with the latest in heat activation and aromatherapy technology to provide you with beneficial, aromatic vapors for relieving cold and cough symptoms, sinusitus, allergies, and congestion. We know that you and everyone who comes within its range will enjoy its many benefits The menthol oil that is diffused into the air in which you breathe, dilates the blood vessels which opens up your air passageways. The eucalyptus oil contains an expectorant (for coughs and colds), and is an antiseptic ¿ kills germs in virus or infections. |
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4 Way Saline Moisturizing Mist, Natural Eucalyptol & Menthol, 1-Ounce Spray Bottles (Pack of 6) by 4-Way 4 Way Saline Moisturizing Mist with natural eucalyptol and menthol helps make nasal passages feel clearer. This mist is alcohol free, non-medicated, and non-habit forming. It can be used with cold/allergy/sinus medications. Soothes dry irritated nasal pas | |
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Cool Menthol Woman - haiku and other verse by Howard Hall (Author) Haiku and poetry from a lifelong writing junkie and working-class poet on the fringes of Philly. This volume began as a handwritten booklet of poetry given as a gift for a friend. It's now been polished up a bit and made available here as a collection of 80 poems (68 haiku, 12 in other formats) culled from years of scrawl in notebooks, journals and on websites. |
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Danger: Rock Science by Menthol |
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Vicks Soothing Vapors Replacement Pads by Vicks Vicks Soothing Vapors Replacement Pads - 5 Pack for Model V1700. |
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Premier King Size Menthol Cigarette Tubes - 5 Boxes by Premier Premier King Size Full Flavor Cigarette Tubes - We carry an awesome selection of Tubes and Machines to Roll Your Own cigarette... ON SALE at our website |
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Chips Eucalyptus Menthol Jujubes 1lb by Chips They really work, say countless devotees of Eucalyptus-Menthol CHIPS. For over five decades, CHIPS lovers have mailed to testify to the dramatic relief these flavorful, jujube-like pastilles provide for dry, scratchy or sore throats. Made with pure eucalyptus oil and menthol, Eucalyptus-Menthol CHIPS offer effective natural relief. Or, if you prefer, they can be enjoyed simply as a tasty and highly refreshing confection. An extensive list of faithful users includes, among others, the Mormon Tabernacle Choir whose members, we're told, fondly refer to CHIPS as "Temple Mints". Only 2.5 calories each! Approx 360 pieces. Made in Italy. Net Wt. 1 Pound |
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Proraso Menthol and Allantoin Aftershave Splash by Proraso A refreshing aftershave splash that will leave your face feeling fresh and conditioned. Contains cooling Menthol, toning Witch Hazel and soothing Allantoin. Made in Florence, Italy since 1926, Proraso is the quintessential classic shaving product. Formulated with a combination of eucalyptus oil, menthol and glycerin, Proraso products provide a smooth, perfect shave, like you would enjoy from your trusted barber. |
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