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Menthol receptor also important in detecting cold temperatures
June 08, 2007New Haven, Conn.-The ion channel activated by menthol also detects a wide range of cold temperatures and relays the information to the brain, according to a study in Nature by Yale School of Medicine, the University of California at San Francisco (UCSF), and the University of Wisconsin.
The finding solves the mystery of how important the ion channel TRPM8 is for alerting the body to cold temperatures.
"TRPM8 is the primary, if not sole, determinant of thermosensitivity in the cool range," the researchers noted. "It also contributes to the detection of extreme cold, or temperatures below 15 C degrees."
Cold, heat, sound, light, taste, and smell are detected and converted into neural impulses through the activation of receptors, which then propagate the signal by opening an ion channel. Once the channel is open, an electrical impulse travels to other neurons.
In this paper, Sven-Eric Jordt, assistant professor of pharmacology at Yale, and colleagues, found that isolated, cultured nerve cells that express TRPM8 react to cooling stimuli, but cells cultured from mice lacking TRPM8 do not. Also, mice engineered without TRPM8 are much less sensitive to cold than mice with TRPM8.
"TRPM8 does not seem to be the sole receptor responsible for detecting cold," Jordt said. "The TRPM8 knockout mice sensed temperatures below 15 C degrees, which indicates the possible existence of another pathway for detecting extreme cold."
Yale University
Cold, heat, sound, light, taste, and smell are detected and converted into neural impulses through the activation of receptors, which then propagate the signal by opening an ion channel. Once the channel is open, an electrical impulse travels to other neurons.
In this paper, Sven-Eric Jordt, assistant professor of pharmacology at Yale, and colleagues, found that isolated, cultured nerve cells that express TRPM8 react to cooling stimuli, but cells cultured from mice lacking TRPM8 do not. Also, mice engineered without TRPM8 are much less sensitive to cold than mice with TRPM8.
"TRPM8 does not seem to be the sole receptor responsible for detecting cold," Jordt said. "The TRPM8 knockout mice sensed temperatures below 15 C degrees, which indicates the possible existence of another pathway for detecting extreme cold."
Yale University
Menthol Current Events and Menthol News RSSStudy finds that tobacco companies changed design of cigarettes without alerting smokers
As President Obama prepares to sign a bill giving the Food and Drug Administration (FDA) oversight of the tobacco industry, a new study from Harvard School of Public Health (HSPH) researchers shows that tobacco manufacturers have continually changed the ingredients and the design of their cigarettes over time, even if those changes have exceeded acceptable product variance guidelines.
Misuse of Vicks VapoRub may harm infants and toddlers
Vicks® VapoRub®, the popular salve used to relieve symptoms of cough and congestion, may be harmful for infants and toddlers.
Popular cold and cough treatment may create respiratory distress in young children
New research out of Wake Forest University Baptist Medical Center suggests that Vicks® VapoRub®, the popular menthol compound used to relieve symptoms of cough and congestion, may instead create respiratory distress in infants and small children.
Tobacco industry manipulated cigarette menthol content to recruit new smokers among young people
Menthol cigarette brands have been rising in popularity with adolescents, and the highest use has been among younger, newer smokers. Researchers at Harvard School of Public Health (HSPH) explored tobacco industry manipulation of menthol levels in specific brands and found a deliberate strategy to recruit and addict young smokers by adjusting menthol to create a milder experience for the first time smoker.
Dairy, Fruits and Veggies May Help Smokers Quit
Milk does the body good — and may help smokers break the habit, say researchers at Duke University Medical Center.
Swishing once a day with mouthrinse poses no harm to dental work
People have been paying more attention to the effects certain liquids like coffee, citrus-containing drinks, and even toothbrushes have on teeth. Mouthrinses are no exception.
Study suggests menthol cigarette smokers may have more difficulty quitting smoking
Menthol and non-menthol cigarettes appear to be equally harmful to the arteries and to lung function, but smokers of menthols may be less likely to attempt or succeed at quitting.
Tobacco industry deceived public with 'low tar' cigarettes
The tobacco industry has deliberately deceived the public with "low tar/light" cigarettes, reveals an analysis in a special supplement to Tobacco Control. Industry documents show that companies recognised that low tar products were as dangerous as regular cigarettes, yet marketed them as healthy alternatives.
Fresh zing to food and drink with the minty flavour
It`s 35 times fresher than mint yet tastes of absolutely nothing GET ready to chill out with the world`s coolest drinks. The secret? A natural food additive with 35 times the cooling power of menthol-but no minty flavour whatsoever. It could bring a supercool fresh tang to a wide range of products, including beer, bottled water, citrus drinks, chocolate and confectionery, says Thomas Hofmann, whose team at the German Research Centre for Food Chemistry in Garching, Munich, discovered the new substance. And because it "cools" skin 250 times as intensely as mint, they say it could add fresh zest to cosmetics such as anti-perspirants.
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Proraso Menthol and Allantoin Aftershave Splash by Proraso A refreshing aftershave splash that will leave your face feeling fresh and conditioned. Contains cooling Menthol, toning Witch Hazel and soothing Allantoin. Made in Florence, Italy since 1926, Proraso is the quintessential classic shaving product. Formulated with a combination of eucalyptus oil, menthol and glycerin, Proraso products provide a smooth, perfect shave, like you would enjoy from your trusted barber. |
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Personal Vaporizer E-liquid from Smoke Plantation- Cool Menthol Flavor 30 ML Bottle MEDIUM Exclusive Personal Vaporizer E-liquid from Smoke Plantation is manufactured to the highest standards. This item is Cool Menthol flavor liquid with varying strengths. This Personal Vaporizer E-liquid ships in 30ML sealed cobalt blue glass containers to keep out damaging light and maintain the freshest product possible. This product is not intended for minors. By purchasing you acknowledge that you are at least 18 years of age. Strengths * Super High - 36mg * XHigh - 24mg * High - 18mg * Medium - 11mg * Low - 6mg |
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