 |
|
Deakin University research finds rogue cells that could cause spread of breast cancer
June 14, 2007Stephanie Lebret completed the study for her PhD at Deakin's Centre for Cellular and Molecular Biology under the supervision of Associate Professor Leigh Ackland.
Ms Lebret is the first to use a particular cell model that mimics the structure of the human breast to map the spread of cancer. Using this model she identified a rogue cell type that may cause cancer cells to move out of the breast.
"As it is not possible to study what happens in the real human mammary gland, we developed a model of the breast using cultured cells grown outside the body. Through this model we first investigated how normal breast development occurs. We then went on to discover how to make these cells behave like migrating cancer cells, which move through the body unlike normal cells, in order to determine what may cause this to happen in the human body," Ms Lebret explained.
"We found that fibroblasts, a cell type that surrounds the mammary gland, help normal breast cells develop but when these fibroblasts are abnormal, they cause breast cancer cells to change and migrate."
Ms Lebret said that this is a preliminary study and that with further research she hopes that it will ultimately lead to preventative treatments for the spread of cancer.
"It is believed there are many ways that cancer may originate. More recently it has been thought that the area surrounding the breast, rather than the breast cells themselves, may play a role in the development of cancer," Ms Lebret said.
"What we have found is important, as it confirms that when abnormal, the cells surrounding the breast produce a specific factor, causing breast cells to change and migrate.
"With further study, it is possible that targeting of this factor may one day be used to prevent the spread of breast cancer."
Research Australia
"We found that fibroblasts, a cell type that surrounds the mammary gland, help normal breast cells develop but when these fibroblasts are abnormal, they cause breast cancer cells to change and migrate."
Ms Lebret said that this is a preliminary study and that with further research she hopes that it will ultimately lead to preventative treatments for the spread of cancer.
"It is believed there are many ways that cancer may originate. More recently it has been thought that the area surrounding the breast, rather than the breast cells themselves, may play a role in the development of cancer," Ms Lebret said.
"What we have found is important, as it confirms that when abnormal, the cells surrounding the breast produce a specific factor, causing breast cells to change and migrate.
"With further study, it is possible that targeting of this factor may one day be used to prevent the spread of breast cancer."
Research Australia
Breast Cells Current Events and Breast Cells News RSSEgg whites solve the 3-D problem
The real world is three-dimensional. That's true even in the laboratory, where scientists have to grow cells to study how they develop and what happens when their growth is abnormal.
Vaccine against HER2-positive breast cancer offers complete protection in lab
Researchers at Wayne State University have tested a breast cancer vaccine they say completely eliminated HER2-positive tumors in mice - even cancers resistant to current anti-HER2 therapy - without any toxicity.
Absence or low function of CHFR gene in breast cells sets stage for abnormal cell division and cancer
A University of Michigan study reveals in detail how breast cells produce new cells that are predisposed to become cancerous, unless they receive the protective action of the CHFR gene.
Molecular 'clock' could predict risk for developing breast cancer
A chemical reaction in genes that control breast cancer provides a molecular clock that could one day help researchers more accurately determine a woman's risk for developing breast cancer and provide a new approach for treatment, UT Southwestern Medical Center researchers have found.
Neuronal regulators offer potential targets for cancer
Being too brainy can be a bad thing in a junior high cafeteria, where the social hierarchy favors other traits. "Braininess" also causes problems for cells.
Vet medicine researcher examines link between cancer, Down syndrome
here's new hope for breast cancer research, and it's coming from a very unlikely place. Researchers at the Texas A&M University College of Veterinary Medicine & Biomedical Sciences recently published articles in the journals Molecular and Cellular Biology and Carcinogenesis indicating that a protein long suspected to play a role in Down Syndrome may also contribute to treating this devastating disease.
Findings Point to Molecular 'Achilles Heel' for Half of Breast Cancer Tumors
Researchers at Lombardi Comprehensive Cancer Center at Georgetown University Medical Center have shown why a protein known as cyclin D1 may be the Achilles heel for breast tumors that are estrogen receptor positive (ER+) − which is the most common type of breast cancer.
'Network' approach identifies potential breast cancer susceptibility gene
Like a crossword-puzzle solver who uses the letters in some answers to figure out others, researchers at Dana-Farber Cancer Institute and an international group of collaborators have used data on genes involved in inherited forms of breast cancer to identify a gene linked to non-hereditary cases of the disease.
New link between estrogen and breast cancer
The female sex hormone estrogen turns on a gene linked to breast cancer, according to new research by Brisbane scientists.
New study suggests Concord grape juice may provide protection against breast cancer
Every three minutes, a woman in the United States is diagnosed with breast cancer . While factors like age and heredity contribute significantly to a woman's likelihood of contracting this disease, lifestyle and nutrition choices may also play a role.
More Breast Cells Current Events and Breast Cells News Articles
| Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells.: An article from: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology by H.Y. Ye, Y.J. Lou This digital document is an article from Phytomedicine: International Journal of Phytotherapy & Phytopharmacology, published by Urban & Fischer Verlag on November 1, 2005. The length of the article is 4460 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase.... | |
 | Increased genotoxic susceptibility of breast epithelial cells to ethylene oxide [An article from: Mut.Res.-Genetic Toxicology and Environmental Mutagenesis] by B. Adam, H. Bardos, R. Adany This digital document is a journal article from Mut.Res.-Genetic Toxicology and Environmental Mutagenesis, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.Description: This study was carried out with the aim of elucidating the organ-specific effects of ethylene... |
| Estrogens shield breast cancer cells.(MOLECULAR BIOLOGY): An article from: Environmental Health Perspectives by M. Nathaniel Mead This digital document is an article from Environmental Health Perspectives, published by Thomson Gale on June 1, 2007. The length of the article is 724 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation... | |
 | Halocynthiaxanthin and fucoxanthinol isolated from Halocynthia roretzi induce apoptosis in human leukemia, breast and colon cancer cells [An article from: ... Biochemistry and Physiology, Part C] by I. Konishi, M. Hosokawa, T. Sashima, H. Kobayashi This digital document is a journal article from Comparative Biochemistry and Physiology, Part C, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.Description: The sea squirt Halocynthia roretzi metabolizes fucoxanthin, and subsequently accumulates its derived... |
| Circulating tumor cells predict outcome in metastatic breast Ca.(Women's Health): An article from: Internal Medicine News This digital document is an article from Internal Medicine News, published by International Medical News Group on April 1, 2005. The length of the article is 469 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation... | |
| HEALTH PLAN'S EXCLUSION FOR ORGAN TRANSPLANTS DOES NOT EXCLUDE COVERAGE FOR HIGH DOSE CHEMOTHERAPY WITH PERIPHERAL STEM CELL RESCUE TO ATTACK BREAST CANCER.: ... article from: Journal of Risk and Insurance This digital document is an article from Journal of Risk and Insurance, published by American Risk and Insurance Association, Inc. on June 1, 2001. The length of the article is 951 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any... | |
| No survival benefit for high-dose chemo plus stem cell transplant for advanced breast cancer.: An article from: Transplant News This digital document is an article from Transplant News, published by Transplant Communications, Inc. on July 25, 2003. The length of the article is 459 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation... | |
 | Mammary Tumor Cell Cycle, Differentiation and Metastasis: Advances in Cellular and Molecular Biology of Breast Cancer (Cancer Treatment and Research) Mammary Tumor Cell Cycle, Differentiation and Metastasis is the fifth volume since 1988 in a series designed to broadly examine current advances in the cellular and molecular biology of breast cancer. As in previous volumes, the editors have invited recognized experts in cutting-edge topics to provide a chapter focused on their area of research. The editors have turned to the researchers who... |
| Daidzein causes cell cycle arrest at the G1 and G2/M phases in human breast cancer MCF-7 and MDA-MB-453 cells.: An article from: Phytomedicine: International ... Journal of Phytotherapy & Phytopharmacology by Eun Jeong Choi, Gun-Hee Kim This digital document is an article from Phytomedicine: International Journal of Phytotherapy & Phytopharmacology, published by Urban & Fischer Verlag on September 1, 2008. The length of the article is 4004 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web... | |
| [beta]-Sitosterol activates Fas signaling in human breast cancer cells.: An article from: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology by A.B. Awad, M. Chinnam, C.S. Fink, P.G. Bradford This digital document is an article from Phytomedicine: International Journal of Phytotherapy & Phytopharmacology, published by Thomson Gale on November 1, 2007. The length of the article is 4729 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view... |
| © 2008 BrightSurf.com |