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Deakin University research finds rogue cells that could cause spread of breast cancer
June 14, 2007Stephanie Lebret completed the study for her PhD at Deakin's Centre for Cellular and Molecular Biology under the supervision of Associate Professor Leigh Ackland.
Ms Lebret is the first to use a particular cell model that mimics the structure of the human breast to map the spread of cancer. Using this model she identified a rogue cell type that may cause cancer cells to move out of the breast.
"As it is not possible to study what happens in the real human mammary gland, we developed a model of the breast using cultured cells grown outside the body. Through this model we first investigated how normal breast development occurs. We then went on to discover how to make these cells behave like migrating cancer cells, which move through the body unlike normal cells, in order to determine what may cause this to happen in the human body," Ms Lebret explained.
"We found that fibroblasts, a cell type that surrounds the mammary gland, help normal breast cells develop but when these fibroblasts are abnormal, they cause breast cancer cells to change and migrate."
Ms Lebret said that this is a preliminary study and that with further research she hopes that it will ultimately lead to preventative treatments for the spread of cancer.
"It is believed there are many ways that cancer may originate. More recently it has been thought that the area surrounding the breast, rather than the breast cells themselves, may play a role in the development of cancer," Ms Lebret said.
"What we have found is important, as it confirms that when abnormal, the cells surrounding the breast produce a specific factor, causing breast cells to change and migrate.
"With further study, it is possible that targeting of this factor may one day be used to prevent the spread of breast cancer."
Research Australia
"We found that fibroblasts, a cell type that surrounds the mammary gland, help normal breast cells develop but when these fibroblasts are abnormal, they cause breast cancer cells to change and migrate."
Ms Lebret said that this is a preliminary study and that with further research she hopes that it will ultimately lead to preventative treatments for the spread of cancer.
"It is believed there are many ways that cancer may originate. More recently it has been thought that the area surrounding the breast, rather than the breast cells themselves, may play a role in the development of cancer," Ms Lebret said.
"What we have found is important, as it confirms that when abnormal, the cells surrounding the breast produce a specific factor, causing breast cells to change and migrate.
"With further study, it is possible that targeting of this factor may one day be used to prevent the spread of breast cancer."
Research Australia
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Walter and Eliza Hall Institute scientists have found that a population of breast cells called luminal progenitor cells are likely to be responsible for breast cancers that develop in women carrying mutations in the gene BRCA1.
1 gene that contributes to breast cancer's aggressive behavior identified
Aggressive forms of cancer are often driven by the abnormal over-expression of cancer-promoting genes, also known as oncogenes.
Dual role in breast tissue for a protein involved in leukemia
A protein known to play a role in growth of some types of leukemia appears to have a mixed function in breast cancer development, say researchers from the Lombardi Comprehensive Cancer Center at Georgetown University Medical Center (GUMC).
Naturally fluorescent molecules may serve as cancer biomarker
Excess amounts of a naturally fluorescent molecule found in all living cells could serve as a natural biomarker for cancer, according to bioengineers.
Cell microenvironments hold key to future stem cell therapies
Adult stem cells and their more committed kin, progenitor cells, are prized by medical researchers for their ability to produce different types of specialized cells. The potential of using these cells to repair or replace damaged tissue holds great promise for cancer therapies and regenerative medicine.
High insulin levels raise risk of breast cancer in postmenopausal women
Higher-than-normal levels of insulin place postmenopausal women at increased risk of breast cancer, researchers at Albert Einstein College of Medicine of Yeshiva University report.
Egg whites solve the 3-D problem
The real world is three-dimensional. That's true even in the laboratory, where scientists have to grow cells to study how they develop and what happens when their growth is abnormal.
Vaccine against HER2-positive breast cancer offers complete protection in lab
Researchers at Wayne State University have tested a breast cancer vaccine they say completely eliminated HER2-positive tumors in mice - even cancers resistant to current anti-HER2 therapy - without any toxicity.
Absence or low function of CHFR gene in breast cells sets stage for abnormal cell division and cancer
A University of Michigan study reveals in detail how breast cells produce new cells that are predisposed to become cancerous, unless they receive the protective action of the CHFR gene.
Molecular 'clock' could predict risk for developing breast cancer
A chemical reaction in genes that control breast cancer provides a molecular clock that could one day help researchers more accurately determine a woman's risk for developing breast cancer and provide a new approach for treatment, UT Southwestern Medical Center researchers have found.
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