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Endosome-mediated signaling in plants
June 19, 2007In a paper that will be published online in advance of its July 1st publication date, Drs. Niko Geldner, Joanne Chory and colleagues (The Salk Institute and HHMI) demonstrate that endosomes can function as signaling platforms in plants, as well as in animals.
"These findings will influence our thinking of the evolutionary origins of endosomes and hopefully help us to understand why cells use them as signaling compartments," noted lead author of the paper, Dr. Niko Geldner.
Endosomes were once thought to function solely in the inactivation of receptors and the down-regulation of cell signaling. Work in animal cells over the past several years has shown that receptor endocytosis can actually facilitate signaling through the cell, by bringing signaling components in contact with their activated receptors.
Drs. Geldner, Chory and collaborators now extend the range of endosome-mediated signaling into the plant kingdom. The researchers show that the growth-promoting brassinosteroid receptor (BRI1) is trafficked through endosomes to enhance activation of this growth response pathway, which affects both shoot and root growth.
Dr. Chory is hopeful that these results "will serve as a springboard for future studies aimed at unraveling the mechanics of how plants grow."
Cold Spring Harbor Laboratory
Drs. Geldner, Chory and collaborators now extend the range of endosome-mediated signaling into the plant kingdom. The researchers show that the growth-promoting brassinosteroid receptor (BRI1) is trafficked through endosomes to enhance activation of this growth response pathway, which affects both shoot and root growth.
Dr. Chory is hopeful that these results "will serve as a springboard for future studies aimed at unraveling the mechanics of how plants grow."
Cold Spring Harbor Laboratory
Certain diseases, birth defects may be linked to failure of protein recycling system
A group of signaling proteins known as Wnt - which help build the human body's skin, bone, muscle and other tissues - depend on a complex delivery and recycling system to ensure their transport to tissue-building cell sites, according to a study at Cincinnati Children's Hospital Medical Center.
New Down syndrome gene identified by Stanford/Packard scientists
Researchers at the Stanford University School of Medicine and Lucile Packard Children's Hospital have identified one possible cause of mental retardation in Down syndrome.
UCSB researchers discover that the cell's endosomes use a surprising transportation system
Cells have developed a surprising transportation system for their endosomes, according to research published today in Physical Review Letters, "Dynamics and Spatial Organization of Endosomes in Mammalian Cells."
More Endosomes Current Events and Endosomes News Articles
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Endosomes (Molecular Biology Intelligence Unit) by Ivan Dikic (Editor) Endosomes are a heterogeneous population of endocytic vesicles and tubules that have captivated the interest of biologists for many years, partly due to their important cellular functions and partly due to their intriguing nature and dynamics. Endosomes represent a fascinating interconnected network of thousands of vesicles that transport various cargoes, mainly proteins and lipids, to distant cellular destinations. How endosomes function, what co-ordinates the molecular determinants at each step of their dynamic life cycle and what their biological and medical relevance is, are among the questions addressed in this book. |
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Endosomes: Webster's Timeline History, 1971 - 2007 by Icon Group International (Author) Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Endosomes," including when used in literature (e.g. all authors that might have Endosomes in their name). As such, this book represents the largest compilation of timeline events associated with Endosomes when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the arts, social sciences... |
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Endosomes and Lysosomes: A Dynamic Relationship, Volume 1 (Advances in Cellular and Molecular Biology of Membranes and Organelles) by B. Storrie (Editor), R.F. Murphy (Editor) The intent in initiating this volume was to bring together a series of essays which would define our present understanding of the endosome and lysosome and their interrelationship. The editors deliberately encouraged the contributors to be speculative; to strive to put order to the "real" world of incomplete and sometimes conflicting data. Seeing science from the laboratory bench can often be like viewing an impressionistic painting from up close; a series of paint dabs with no apparent order. The contributors to this volume were asked to step back and leave the reader with a sense of the whole as well as the detail. To the extent that this has happened, the credit should go to the individual authors. Our understanding of endosomes and lysosomes has undergone a molecular... |
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