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Nanoparticles carry chemotherapy drug deeper into solid tumors
June 27, 2007A new drug delivery method using nano-sized molecules to carry the chemotherapy drug doxorubicin to tumors improves the effectiveness of the drug in mice and increases their survival time, according to a study published online June 26 in the Journal of the National Cancer Institute.
In the past, similar drug carriers have improved targeted delivery of the drugs and reduced toxicity, but they sometimes decreased the drugs' ability to kill the tumor cells. Using a new drug carrier, Ning Tang of the Chinese Academy of Sciences in Beijing and colleagues compared tumor growth and survival in mice that were given doxorubicin in the nanocarriers or on its own.
Doxorubicin delivered by nanocarriers was more effective in preventing tumor growth than free doxorubicin, and the mice receiving this treatment method lived longer and had fewer toxic side effects.
"Encapsulation of doxorubicin-increased its accumulation and penetration in tumors in terms of both the percentage of cells that were reached by the drug and the intracellular levels that were attained," the authors write.
In an accompanying editorial, Matthew Dreher, Ph.D., of the National Institutes of Health in Bethesda, Md., and Ashutosh Chilkoti, Ph.D., of Duke University in Durham, N.C., discuss the future of drug delivery, which they think should focus on three important research areas-drug combinations, targeting, and integration.
"The study by Tang [and colleagues] is a simple but effective demonstration of the benefits of integration of a drug with an appropriate carrier to yield a striking gain in efficacy," the authors write. "May the days of pharmacological missiles that miss their target and friendly fire that kills patients soon be over!"
Journal of the National Cancer Institute
"Encapsulation of doxorubicin-increased its accumulation and penetration in tumors in terms of both the percentage of cells that were reached by the drug and the intracellular levels that were attained," the authors write.
In an accompanying editorial, Matthew Dreher, Ph.D., of the National Institutes of Health in Bethesda, Md., and Ashutosh Chilkoti, Ph.D., of Duke University in Durham, N.C., discuss the future of drug delivery, which they think should focus on three important research areas-drug combinations, targeting, and integration.
"The study by Tang [and colleagues] is a simple but effective demonstration of the benefits of integration of a drug with an appropriate carrier to yield a striking gain in efficacy," the authors write. "May the days of pharmacological missiles that miss their target and friendly fire that kills patients soon be over!"
Journal of the National Cancer Institute
Chemotherapy Drug Current Events and Chemotherapy Drug News RSSAn exquisite container
In campy old movies, Lucretia Borgia swans around emptying powder from her ring into wine glasses carelessly left unattended. The poison ring is usually a confection of gold filigree holding a cabochon or faceted gemstone that can be broken to empty the ring's contents. It is invariably enormous - so large it is rather odd nobody seems to notice it.
Drug could provide first treatment for scleroderma
Investigators have identified a drug that is currently approved to treat certain types of cancer, Gleevec, that could provide the first treatment for scleroderma, a chronic connective tissue disease for which a treatment has remained elusive.
New multi-use device can shed light on oxygen intake
A fiber-optic sensor created by a team of Purdue University researchers that is capable of measuring oxygen intake rates could have broad applications ranging from plant root development to assessing the effectiveness of chemotherapy drugs.
Sorafenib significantly improves the length of time before breast cancer worsens
ne of the first of a series of trials to investigate the use of sorafenib - a targeted anti-cancer drug - for the treatment of advanced breast cancer has found that if it is combined with the chemotherapy drug, capecitabine, it makes a significant difference to the time women live without their disease worsening.
Adding cetuximab to chemotherapy reduces advanced lung cancer death risk by 13 percent
Patients with advanced non-small cell lung cancer who are given cetuximab (Erbitux) in addition to chemotherapy are 13% less likely to die than those who receive chemotherapy alone, regardless of which chemotherapy drug cocktail is used, new research finds. They also experience slower disease progression and an increased chance of tumour shrinkage.
Avastin dramatically improves response, survival in deadly recurrrent glioblastomas
The targeted therapy Avastin, alone and in combination with the chemotherapy drug CPT-11, significantly increased response rates, progression-free survival times and survival rates in patients with a deadly form of brain cancer that had recurred.
Study supports DNA repair-blocker research in cancer therapy
Scientists at Dana-Farber Cancer Institute have uncovered the mechanism behind a promising new approach to cancer treatment: damaging cancer cells' DNA with potent drugs while simultaneously preventing the cells from repairing themselves.
Sensitizing tumor response to cancer therapy
Two forms of skin and brain cancer respond very poorly to chemotherapy and radiation: melanoma and glioblastoma multiforme brain cancer.
EphA2-targeted therapy delivers chemo directly to ovarian cancer cells
With a novel therapeutic delivery system, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center has successfully targeted a protein that is over-expressed in ovarian cancer cells.
Common chemotherapy drug triggers fatal allergic reactions
A chemotherapy drug that is supposed to help save cancer patients' lives, instead resulted in life-threatening and sometimes fatal allergic reactions.
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Physicians' Cancer Chemotherapy Drug Manual: 2009 by Edward Chu (Author), Vincent DeVita Jr. (Author) Completely revised and updated for 2009, the Physicians Cancer Chemotherapy Drug Manual is an up-to-date guide to the latest information on standard therapy and recent advances in the field. Written by world-class experts in the clinical cancer therapeutics, this essential reference provides a complete, easy-to-use catalogue of over 100 drugs and commonly used drug regimens both on-and off-label for the treatment of all the major cancers. Special features: Features new drugs: Bendamustine, Ixabepilone, and Nilotinib; Revised to reflect rapid advances in the field, incorporating new drug and treatment strategies; diagrams of drug structures and pathways for each agent; Offers a comprehensive discussion of clinical pharmacology, special considerations, indications, and dosages; Covers... |
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Cancer: Symptoms & Treatment History (1940s) [DVD] Cancer is an interesting short film that explains the signs and symptoms of cancer and its treatment. It features Mr. Bert Marshall, an average man who was diagnosed with stomach cancer. Aside from illustrations of the human anatomy and how cancer cells develop, the film also shows the disease is not only a physical burden but also an emotional weight by showing Mr. Marshall getting depressed and worried. Mr. Marshall is shown sitting on a bench at a park and deeply worried about telling his family about the disease. This educational film also features how cancer is treated by using x-ray fluoroscopy. Most importantly, the film also gave emphasis on identifying the "7 danger signs of cancer" which include (1) any sore that does not heal; (2) a lump or thickening of the breast or... |
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