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A genetic factor predicts prognosis in brain tumor patients
June 28, 2007PLoS ONE has just published a study which defines a gene locus on chromosome 1 that predicts prognosis of brain tumor patients and may even set the basis for the development of more efficient drugs to combat brain cancer. Clinical and basic researchers from the University Hospital Basel, Switzerland, the Heinrich Heine University Düsseldorf, Germany, and the Emory University Atlanta, USA have defined the Notch2 gene as candidate gene for brain tumor development. The study was coordinated by Adrian Merlo, neurosurgeon at the University Hospital Basel.
The Notch2 locus highly predicts survival in subgroups of brain tumor patients. This gene is an important regulator of developmental processes. Taking advantage of a complex DNA duplication involving the Notch2 gene, the researchers developed a molecular assay that unambiguously distinguishes prognostically favorable brain tumor cases from cases that show rapid tumor progression.
In ongoing studies, the Basel researchers, supported by Ruth Chiquet from the Friedrich Miescher Institute, have found that Notch2 upregulates the tenascin-C gene which is well known to play a critical role in brain tumorigenesis. This new brain tumor pathway does not only offer precise diagnostic information, but also defines new targets for molecular intervention to develop drugs against this severe human disease.
Public Library of Science
Public Library of Science
Brain Tumor Current Events and Brain Tumor News RSSChildhood cancer survivors less likely to marry, Yale researchers find
Adult survivors of childhood cancer are 20 to 25 percent more likely to never marry compared with siblings and the general population, Yale School of Medicine researchers report in a new study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
Brain tumors in childhood leave a lasting mark on cognition, life status
Brain tumors in childhood cast a long shadow on survivors. The first study of the lasting impact of these tumors -- the most common solid malignancies in childhood -- shows that survivors have ongoing cognitive problems.
Angiochem crosses BBB, shows safety, efficacy in phase 1/2 brain cancer studies
Angiochem, Inc. a clinical-stage biotechnology company developing drugs that are uniquely capable of crossing the blood-brain barrier to treat brain diseases, announced today that its lead drug candidate, ANG1005, has demonstrated a favorable safety and efficacy profile in more than 100 patients with brain cancer from two separate Phase 1 /2 clinical studies in patients with progressive gliomas, including recurrent glioblastoma, and in patients with progressive brain metastases.
Researchers report benefits of new standard treatment study for rare pediatric brain cancer
A team of researchers led by The University of Texas M. D. Anderson Cancer Center unveiled results today from the largest-ever collaborative study addressing the treatment of a rare pediatric brain tumor.
Unequal access: Hispanic children rarely get top-notch care for brain tumors
Hispanic children diagnosed with brain tumors get high-quality treatment at hospitals that specialize in neurosurgery far less often than other children with the same condition, potentially compromising their immediate prognosis and long-term survival, according to research from Johns Hopkins published in October's Pediatrics.
tudy: The new buzz on detecting tinnitus
It's a ringing, a buzzing, a hissing or a clicking - and the patient is the only one who can hear it. Complicating matters, physicians can rarely pinpoint the source of tinnitus, a chronic ringing of the head or ears that can be as quiet as a whisper or as loud as a jackhammer.
New Approach for the Treatment of Malignant Brain Tumors
Initial chemotherapy alone after surgery is just as successful as initial radiation therapy for patients from whom a very malignant brain tumor (anaplastic glioma) was removed. With this treatment, the patients survive on average > 30 months without a recurrence.
Weizmann Institute Scientists Discover A New Protein Partnership That Leads to Pediatric Tumor Regression
Why are some pediatric cancers able to spontaneously regress? Prof. Michael Fainzilber and his team of the Weizmann Institute's Biological Chemistry Department seem to have unexpectedly found part of the answer.
Why don't brain tumors respond to medication?
Malignant brain tumors often fail to respond to promising new medication. Researchers in Heidelberg have discovered a mechanism and a tumor marker for the development of this resistance.
NIH researchers identify key factor that stimulates brain cancer cells to spread
Researchers funded by the National Institutes of Health have found that the activity of a protein in brain cells helps stimulate the spread of an aggressive brain cancer called glioblastoma multiforme (GBM).
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Living with a Brain Tumor: Dr. Peter Black's Guide to Taking Control of Your Treatment by Peter Black (Author) Each year, 100,000 people in the United States are diagnosed with a brain tumor. With his new book, Dr. Peter Black fills a gap in the lay readership, providing an accessible medical resource for adult patients and their families. Dr. Black, who has operated on more than 3,000 patients with brain tumors, is uniquely qualified to discuss both clinical treatment of and research into brain tumors. This invaluable resource tells patients everything they need to know to understand and address their diagnosis, in a four-part structure: • “What is a Brain Tumor?" provides straightforward information about how brain tumors are diagnosed, the different types of tumors and how they develop, and where to go for treatment. • “Coping with Shock” addresses the emotional... |
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Curveball: When Life Throws You a Brain Tumor by Liz Holzemer (Author) Life seemed idyllic for thirty-two-year-old Liz Holzemer. Wife of Major League Baseball pitcher Mark Holzemer, Liz was enjoying a successful career as a journalist when an MRI revealed a baseball-size brain tumor she soon found out was called meningioma. Told with clarity and unwavering humor, this book is an inspirational and informative account of one woman’s battle for her life. It shows how she emerged from this frightening diagnosis and two brain surgeries retaining her remarkable spirit of survival and renewed sense of purpose and hope. With practical information about meningioma and brain surgery, Curveball is a manual for people who face life-altering challenges and is also proof that one need not fight such battles alone. |
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Damn The Statistics, I Have a Life to Live!: Coping with a Brain Tumor My Personal Story by Harry Wolf (Author) June 3, 2002 was the day that changed my life forever. A 43-year-old father of three, whom in oneday went from being a successful senior manager to a man with a braintumor. I have a glioblastoma multiformegrade IV brain tumor, the most deadly and aggressive type of brain tumor. This book covers how I have dealt with lifeafter being informed that I have a tumor that only 1-2% survive for 2years. I share the experiences, thoughts,and events from my first year as a survivor. When I was first diagnosed, I searched for a book that covered thedetails of what could be expected on both a medical and personal level. I could not find, so I wrote one. I maintained a detailed journal. I cover the first surgery, an awakecraniotomy, and the subsequent head infection that led to a second... |
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Guerilla Guide to Brain Tumors: Shameless Dirty Tricks to beat the system and STAY ALIVE! by Skip Goebel (Author) In an unprecedented format, the Guerilla Guide to Brain Tumors is written in a format that combines the layout of the For Dummies series with a drill-sargent's attitude. (the back page says it all) This is a book of War Nothing warm and fuzzy or socially acceptable here and nothing about "Dying with Dignity". Just what it takes to win. And win you will, complete with a trail of wreckage behind you. It's a book for the patient, NOT the caregiver. The Guerilla Guide to Brain Tumors is a book that will take you out of the "Grovel and Wretch" mode and into the "Command and Dominate" mode with the following factions of our society: The Medical EstablishmentThe Social Services EstablishmentChurch, Friends and FamilyAnd most importantly...Yourself No punches are pulled here. Prepare to be... |
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Brain Tumors: Leaving the Garden of Eden--A Survival Guide to Diagnosis, Learning the Basics, Getting Organized, and Finding Your Medical Team by Paul M. Zeltzer (Author) A guidebook for the 150,000+ people/ year and families affected by brain tumors. This book will help you learn the basics about diagnosis, getting organized and finding your medical team. Included are chapters on all major types of brain tumors & metastases, glossary, medications, using the Internet to search for information, and getting a second opinion. "Brain Tumors:Leaving the Garden of Eden" is all about improving your odds by gathering information, & assessing your situation: What you need to do; what you need to know; what you can do now! |
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Dark Victory (Restored and Remastered Edition) Starring: Bette Davis, George Brent, Humphrey Bogart, Geraldine Fitzgerald, Ronald Reagan Directed By: Edmund Goulding Also With: Ernest Haller (Cinematographer), William Holmes (Editor), David Lewis (Producer), Hal B. Wallis (Producer), Bertram Bloch (Writer), Casey Robinson (Writer), George Emerson Brewer Jr. (Writer) Bette Davis?s bravura, moving-but-never-morbid performance as Judith Traherne, a dying heiress determined to find happiness in her few remaining months, remains a three-hankie classic. But that success would never have happened if Davis hadn?t pestered studio brass to buy Dark Victory?s story rights. Jack Warner finally did so skeptically. Who wants to see a dame go blind? he asked. Almost everyone: Dark Victory was Davis? biggest box-office hit yet and garnered Academy Award nominations for 1939?s Best Picture, Actress and Original Score (Max Steiner). |
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100 Q&A About Brain Tumors (100 Questions & Answers) by Virginia Stark-Vance (Author) Consumer text provides authoritative, practical answers to questions regarding treatment options, post-treatment quality of life, and sources of support. Co-authored by a brain-tumor survivor, text explains what to expect after the diagnosis and the treatment of a brain tumor. Softcover. |
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Brain Surgeon: A Doctor's Inspiring Encounters with Mortality and Miracles by Keith Black (Author), Arnold Mann (Author) Welcome to tiger country: the treacherous territory where a single wrong move by a brain surgeon can devastate-or end-a patient's life. This is the terrain world-renowned neurosurgeon Keith Black, MD, enters every day to produce virtual medical miracles. Now, in BRAIN SURGEON, Dr. Black invites readers to shadow his breathtaking journeys into the brain as he battles some of the deadliest and most feared tumors known to medical science. Along the way, he shares his unique insights about the inner workings of the brain, his unwavering optimism for the future of medicine, and the extraordinary stories of his patients-from ministers and rock stars to wealthy entrepreneurs and uninsured students-whom he celebrates as the real heroes. BRAIN SURGEON offers a window into one man's... |
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Cure Brain Tumor Long Sleeve T-shirt Large White by Shop Zeus |
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Brain ElevateTM Vegetarian - 60 Count by NOW Foods For centuries, Eastern civilizations have relied on Huperzine as a broadly useful herbal health aid. It was only recently discovered however, that this rare moss extract has the ability to prevent the breakdown of acetylcholine - a chemical in the brain that plays a substantial role in cognitive clarity and memory function. By combining this extract with a proprietary blend of other natural substances that help protect neuronal tissue and improve blood flow (RoseOx®, Ginko Biloba, L-Glutamine and more), NOW Brain Elevate Vcaps may be advantageous for elevating cognitive performance. |
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