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Antibodies protect mice from developing respiratory tularemia
June 28, 2007WHAT: The respiratory form of tularemia, a potentially serious bacterial disease, is a significant public health concern because it is highly infectious, it has a high mortality rate if untreated, and it could be introduced into a population in an intentional act of bioterror. Though much research is focused on developing drugs and vaccines targeted to the bacterium that causes tularemia, Francisella tularensis, little is known about the role that antibodies play in protecting against infection.
A research team led by Dennis W. Metzger, Ph.D., at the Albany Medical College in New York has now shown that treating laboratory mice with a serum containing tularemia-specific antibodies protects the mice against F. tularensis, not only if given before exposure to lethal doses of inhalational F. tularensis but also up to 48 hours after exposure. These findings suggest a possible alternative treatment approach to traditional antibiotics. In the absence of a licensed vaccine, such an approach might prove especially useful early on in the case of an intentional act of bioterrorism. The tularemia-specific antibodies may enhance an individual's immune responses to the bacteria after exposure, in essence acting as a surrogate vaccine. Other advantages of this approach over conventional methods of treatment include the fact that it is rapid and specific; it could be used in people with weakened immune systems; and it minimizes the chances of contributing to treatment-resistant bacteria.
NIH/National Institute of Allergy and Infectious Diseases
Tularemia Current Events and Tularemia News RSSOutfoxing pox: Developing a new class of vaccine candidates
In the annals of medicine, Edward Jenner's 1796 vaccination of a young boy against smallpox, using fluid from cowpox blisters, remains a landmark case. In a new study, Kathryn Sykes, a researcher at Arizona State University's Biodesign Institute and her colleagues have taken a fresh look at cowpox.
Researchers find pathway and enzyme unique to tularemia organism
Researchers are closer to developing therapies to combat the deadly tularemia infection, according to a study published this week in the Proceedings of the National Academy of Sciences' online Early Edition.
UCLA develops safer, more effective TB vaccine for HIV-positive people
UCLA scientists engineered a new tuberculosis (TB) vaccine specifically designed for HIV-positive people that was shown to be safer and more potent than the current TB vaccine in preclinical trials.
Researchers uncover molecule that keeps pathogens like salmonella in check
Scientists at UT Southwestern Medical Center have found a potential new way to stop the bacteria that cause gastroenteritis, tularemia and severe diarrhea from making people sick.
Francisella tularensis: Stopping a biological weapon
Scientists hope a vaccine is on the horizon for tularemia, a fatal disease caused by the pathogen Francisella tularensis, an organism of concern as a potential biological warfare agent. Until recently we knew very little about this bacterium.
UTSA/UTHSCSA publish results on bio-threat agent
Researchers at The University of Texas at San Antonio (UTSA) South Texas Center for Emerging Infectious Diseases and The University of Texas Health Science Center at San Antonio (UTHSCSA) have identified a cell type believed to play a role in controlling the early infectious process against Francisella tularensis, a respiratory pathogen and bioterrorism agent that is the cause of tularemia.
Study gives clues about how deadly bacterium gains foothold
How a potentially deadly bacterium that could be used as a bioterrorist tool eludes being killed by the human immune system is now better understood.
Study gives clues about how deadly bacterium gains foothold
How a potentially deadly bacterium that could be used as a bioterrorist tool eludes being killed by the human immune system is now better understood, University of Iowa researchers report in the December issue of the Journal of Leukocyte Biology.
New NIAID program aims to model immune responses and key infectious diseases
A new program at the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health (NIH), aims to better understand the complex biochemical networks that regulate the interactions between infectious organisms and the human or animal cells they infect.
Tiny avalanche photodiodes target bioterrorism agents
After the anthrax attacks in the United States in 2001 the threat of a larger and more deadly bioterrorism attack - perhaps from smallpox, plague or tularemia - became very real. But the ability to detect such biological agents and rapidly contain an attack is still being developed.
More Tularemia Current Events and Tularemia News Articles
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Tularemia (Deadly Diseases and Epidemics) by Susan Hutton Siderovski (Author) |
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Gale Encyclopedia of Medicine: Tularemia by Rosalyn Carson-DeWitt MD (Author) The article is excerpted from Gale Encyclopedia of Medicine. Consult the second edition of this authoritative, comprehensive, in-depth medical guide for information on more than 1,700 medical topics in language accessible to adult laypersons. Presented in a single alphabetical sequence, articles range in length from one or two paragraphs for minor topics, to several pages or more for major topics. Disease/disorder articles typically cover definition; description; causes and symptoms; diagnosis; treatments; prevention; and more. Test/treatment articles typically cover definition; purposes; precautions; preparation; risks; normal and abnormal results; and much more. This second edition includes more than 200 new entries, 300 updated entries, approximately 650 color... | |
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Tularemia: An entry from Gale's Gale Encyclopedia of Medicine, 3rd ed. by Rosalyn, MD Carson-DeWitt (Author) This digital document is an article from Gale Encyclopedia of Medicine, 3rd ed., brought to you by Gale®, a part of Cengage Learning, a world leader in e-research and educational publishing for libraries, schools and businesses. The length of the article is 362 words. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. The third edition of this authoritative, comprehensive, in-depth medical guide features information on medical topics in language accessible to adult laypersons. Disease/disorder articles typically cover definition; description; causes and symptoms; diagnosis; treatments; prevention; and more. Test/treatment articles typically cover definition; purposes;... | |
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"Tularemia": An entry from Gale's American Decades: Primary Sources by Gale (Publisher) This digital document is an article from American Decades: Primary Sources, brought to you by Gale®, a part of Cengage Learning, a world leader in e-research and educational publishing for libraries, schools and businesses. The length of the article is 1639 words. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. American Decades Primary Sources provides fresh insight into the decade's most important events, people, and issues. Entries representing a diversity of views that provide insight into the seminal issues, themes, movements and events from the decade. Also included are concise contextual information, notes about the author and further resources. American Decades Primary... | |
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Bioterrorism Tularemia Manual and CD: For Healthcare Workers and Public Officers (Allied Health, Nurses, Doctors, Public Health workers, EMS workers, other ... Introduction on Infection and Treatment by Daniel Farb (Author) This title is part of the UniversityOfHealthCare/ UniversityOfBusiness Interactive Training Library, which offers authoritative, clearly written material in an interactive form for better comprehension and documentation of completion. The manual accompanying the CD provides a summary of the major points of the CD in a handy format. Bioterrorism Tularemia teaches health workers in particular and lay people in general about the disease tularemia and how to apply that knowledge in a bioterror attack. It covers the transmission, prevention, diagnosis, clinical manifestations, and therapy of the disease. It includes questions on case studies and an exam. Approved for 2 hours of EMS Continuing Education in Maryland. Approved for national nursing contact hours--requires purchase of... |
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Tularemia Medical Guide by Qontro Medical Guides (Author) The Tularemia Medical Guide is a publication which has been designed to better help readers understand Tularemia. This Qontro Medical Guide has been designed with the reader in mind, and is a useful information source for readers at all levels looking to learn more about Tularemia. The Tularemia Medical Guide is highly recommended for those interested in understanding and learning more about Tularemia. |
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Bioterrorism Smallpox Library Edition: For Healthcare Workers, Public Officers (Allied Health, Nurses, Doctors, Public Health Workers, EMS Workers, Other ... Plague, Radiation, Smallpox, and Tularemia by Daniel Farb (Author) Smallpox has been one of the scourges of mankind until it was supposedly eradicated in 1980. But there are indications that it is being preserved for use in bioterrorism and is considered a major threat by the US government. Bioterrorism Smallpox teaches you about the organism that causes smallpox, its transmission, its laboratory and clinical diagnosis, its clinical manifestations, its treatment, its prevention by vaccination, the significant side-effects of the vaccination, and the bioterror parameters of the disease. Two fictional and interactive scenarios are presented for review. The course is a clear, interactive presentation of the problems facing anyone who has to deal with the disease, with a special emphasis on healthcare workers, and is written to be understood well by people... |
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Multiple Francisella tularensis subspecies and clades, tularemia outbreak, Utah.(DISPATCHES)(Report): An article from: Emerging Infectious Diseases by Jeannine M. Petersen (Author), Jennifer K. Carlson (Author), Gabrielle Dietrich (Author), Rebecca J. Eisen (Author), Jana Coombs (Author), Aimee M. Janusz (Author), JoDee Summers (Author), C. Ben Beard (Author), Paul S. Mead (Author) This digital document is an article from Emerging Infectious Diseases, published by U.S. National Center for Infectious Diseases on December 1, 2008. The length of the article is 1928 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser. Citation Details Title: Multiple Francisella tularensis subspecies and clades, tularemia outbreak, Utah.(DISPATCHES)(Report) Author: Jeannine M. Petersen Publication: Emerging Infectious Diseases (Magazine/Journal) Date: December 1, 2008 Publisher: U.S. National Center for Infectious Diseases Volume: 14 Issue: 12 Page: 1928(3) Article Type: Report Distributed by Gale, a part... | |
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Bioterrorism Radiation Library Edition: For Healthcare Workers, Public Officers (Allied Health, Nurses, Doctors, Public Health Workers, EMS Workers, Other Emergency, Safety, Fire, Police, and Disaster Planning and Response Personnel) and the Public, Detailed Introduction to the Most Dangerous Forms of Bioterrorism, Including Anthrax, Botulinum, Hemorrhagic Viruses, Plague, Radiation, Smallpox, and Tularemia by Daniel Farb (Author) Bioterrorism Radiation gives details on dealing with a radiation disaster. It was written to be accessible for both health care professionals and the public. You will learn threat scenarios, fundamentals of radiation and its damage, policies for the public, tactics for pre-hospital emergency services, learn plans for hospital medical management, learn strategies for hospital emergency care of victims, and gain insight from previous radiation catastrophes. The course is a clear, interactive presentation of the problems facing anyone who has to deal with the disease, with a special emphasis on healthcare workers, and is written to be understood well by people outside of healthcare. The course contains animations and movies. The manual accompanying the CD provides a summary of the major... |
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Tularemia - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by ICON Health Publications (Author) In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading." Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing.This book was created for medical professionals, students, and members of the general public who want to conduct medical research using the most advanced tools available and spending the least amount of time doing so. |
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