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Protecting HIV patients from Hepatitis B virus
July 18, 2007Since the transmission of HIV and Hepatitis B virus (HBV) are so similar, individuals infected with one of these viruses are at a significantly increased risk for contracting the other. As it is not quite clear how patients that don't respond to the HBV vaccine should be managed, new research from the University of Alberta has evaluated the immune response of HBV vaccine given intradermally (into the skin) in HIV-infected individuals who failed to respond to two cycles of HBV vaccine given intramuscularly (into the muscle).
"Because those infected with HIV are at a greater risk for contracting HBV, it is crucial we promote HBV immunizations and continue to put our research efforts into why some HIV patients fail to respond to the vaccine," said Dr. Stephen Shafran, Professor and Director, Division of Infectious Diseases, at the University of Alberta.
Protecting persons with HIV from contracting the HBV is an important goal. However, people with HIV have a substantially lower success rate with the HBV vaccine compared to the general population.
For this study, researchers were particularly interested in measuring the levels of antibody to hepatitis B produced (called anti-HBs) because the presence of anti-HBs is considered the marker of immunity to HBV infection. Of the patients tested in the cohort, when given the HBV vaccine intradermally rather than intramuscularly, 50 per cent of the subjects successfully produced protective levels of anti-HBs after four doses of vaccine. Conversely, the remaining 50 per cent of patients still did not produce anti-HBs even after given additional doses of HBV vaccine.
"Based on our study we can conclude that administering HBV vaccine intradermally cannot be recommended for HIV-infected adults who did not respond initially to intramuscular administered vaccine," said Shafran. "Other vaccine strategies, perhaps involving multiple antigens or adjuvants, will need to be investigated."
University of Alberta
For this study, researchers were particularly interested in measuring the levels of antibody to hepatitis B produced (called anti-HBs) because the presence of anti-HBs is considered the marker of immunity to HBV infection. Of the patients tested in the cohort, when given the HBV vaccine intradermally rather than intramuscularly, 50 per cent of the subjects successfully produced protective levels of anti-HBs after four doses of vaccine. Conversely, the remaining 50 per cent of patients still did not produce anti-HBs even after given additional doses of HBV vaccine.
"Based on our study we can conclude that administering HBV vaccine intradermally cannot be recommended for HIV-infected adults who did not respond initially to intramuscular administered vaccine," said Shafran. "Other vaccine strategies, perhaps involving multiple antigens or adjuvants, will need to be investigated."
University of Alberta
HBV Current Events and HBV News RSSToward explaining why hepatitis B hits men harder than women
Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women.
1 disease, not 1 demographic
The Asian continent has nearly four billion people living in 47 different countries, and each of these groups has their own unique set of health issues. But when they come to the United States, they're often lumped into one large demographic: "Asian/Pacific Islander."
HBV genotype B/B3 and C/C1 are the major genotypes in Indonesia?
Previous studies revealed that HBV genotypes as well as mutations in the core promoter, precore or HBx gene have been shown to have an association with the clinical outcome of liver disease, however, this is still controversial.
oes peripheral T-lymphocyte subpopulations correlate with hepatitis B virus load?
Hepatitis B virus (HBV) infection is a dynamic process with variable biochemical, virological and histological profiles at different stages of the infection, depending on host and viral factors. Furthermore, this profile may change at a variable pace over time.
Focusing HIV treatment helps control concurrent hepatitis B infection
Prolonged use of highly active antiretroviral therapy (HAART) to treat people infected with both HIV and hepatitis B (HBV) helps to better control the hepatitis B infection and could delay or prevent liver complications.
DKK-3 and WIF-1: Proteins related to liver cancer development?
Liver cancer is one of the most fatal human malignancies and the third most frequent cause of tumor-related death, about half a million people globally each year.
Future for radioembolisation in patients with advanced hepatocellular carcinoma
Copenhagen, Denmark, Friday 24 April: Radioembolisation with Yttrium-90 (Y-90) glass microspheres is a safe and effective treatment for patients with advanced HCC ± portal vein thrombosis, according to new research presented today at EASL 2009, the Annual Meeting of the European Association for the Study of the Liver in Copenhagen, Denmark.
Do patients at risk for B-cell malignancy need antiviral treatment?
Some studies have shown that a relationship of hepatitis C (HCV) infection with type II mixed cryoglobulinemia exists. However the precise mechanism remains unclear.
Models Simulate Nitrate Dynamics in Garonne, Southwest France
The over-enrichment of fresh, transitional, and marine waters with nitrogen (N) can lead to problems associated with eutrophication, such as a change in species composition of aquatic plants and nuisance algal blooms. In this context, dynamic models of flow and water quality are required to aid the implementation of the Water Framework Directive and to understand the impacts of environmental change.
If the diabetes has a direct carcinogenetic effect?
The association of DM2 with solid tumors, and particularly with HCC, has been long suspected and several studies have reported increased mortality rates for neoplastic diseases in patients with DM2.
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Chronic HBV seen in 9% of Asian immigrants.(Infectious Diseases): An article from: Family Practice News by Patrice Wendling (Author) This digital document is an article from Family Practice News, published by Thomson Gale on April 15, 2007. The length of the article is 528 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Chronic HBV seen in 9% of Asian immigrants.(Infectious Diseases) Author: Patrice Wendling Publication: Family Practice News (Magazine/Journal) Date: April 15, 2007 Publisher: Thomson Gale Volume: 37 Issue: 8 Page: 20(2) Distributed by Thomson... | |
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LENMAR HBV-522 RCA/Hitachi Full-Size VHS Replacement Camcorder Battery by LENMAR Select from a wide range of Lenmar batteries designed for longer-running power than most original manufacturer's batteries. Always pre-tested for quality, the cells deliver consistent performance. Lenmar offers a full range of the most popular and hard-to-find battery sizes, including sizes for early model camcorders. This battery replaces the Hitachi VHS 12V 1800mAh and is to be used with BCR10, BCR3312V chargers. |
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Scosche Vo00B Wiring Harness For 1981 and Up Select Volvo by SCOSCHE Scosche is going to keep doing what it's best at: designing, developing and bringing to market technically superior and reasonably priced car audio products. Scosche Industries attributes its success to several factors, not the least of which is talented, enthusiast people. The emphasis on only producing the finest quality products at reasonable prices, and providing the consumer with easy to use, well-designed functional accessories has been the key to success. This wiring harness is designed to wire up an aftermarket headunit without having to cut the factory wiring. For easy installation, each wire labeled and uses the EIA standard wiring color codes. This specific wiring harness works with 1981 & up Select Volvo automobiles. |
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AV SPRING HU HBV 225 by Husqvarna AV SPRING HU HBV 225 |
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Midwest Control HBV-200 2"fxf 600 Psi Forged Brass Ball Valve by Midwest Control Brass NSF Approved Ball Valves Material: Brass Fractional Pipe Size: 2 Type: UL, CSA, FM, NSF Approved Style: In-Line - Two Way Flow WOG Rating (psi): 600 Steam Pressure Rating (psi): 150 |
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R3383 REJECT BLACK LEATHER MILITARY D-3A GLOVES-RUSTED BUCKLE (5) by Rothco GENUINE COWHIDE LEATHER RUSTY BUCKLE COTTON PULL CLOSURE COTTON PIPING IN BLACK *NEW FEATURE: PLASTIC FASTENER CONNECTING PAIRS TOGETHER AT WRIST STRAP | |
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SCREW SET HBV3 CEHCNE055A by Century Helicopter This is the replacement Screw Set for the Century / Helicoper Hummingbird V3 ARF - CEHE1020. / / FEATURES: Direct fit replacement part / / INCLUDES: Two 2.5x5mm phillips head screws / Two 3x5mm phillips head screws / Two 2x5mm phillips head screws / Two 1.5x4mm flat head screws / Two 1x3mm phillips head screws / Two 2mm nuts / One 1.5x3mm phillips head screw (black in color) / Two 3x3mm set screws (requires a 1.5mm hex wrench to install) / Two 2.5x8mm flat washers / Two 3x7mm flat washers / Two 1x4mm flat washer / One 46mm long piece of tubing (1mm inside diameter) / / REQUIRES: Installation following the kit manual / / kpm11/02/2005 / ir/jxs | |
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EPA approved - Protex Disinfectant Spray Bottle, 12 oz. Efective against MRSA, E-coli, influenza, H1N1, Herpes, HBV, VISA, VRE, HCV, HIV. by Parker Labs A powerful one-step disinfectant effective against a broad spectrum of pathogens, including MRSA, HIV, Staph and many others. Useful in disinfecting ultrasound transducers, probes, mammography compressor plates and other hard nonporous, non-surgical surfaces. Protex is an EPA approved, one-step spray that effectively kills a wide range of bateria, viruses, and fungi including: MRSA, E-coli, influenza, H1N1, Herpes, HBV, VISA, VRE, HCV, HIV Salmonella and Norwalk Virus. |
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Innate V2 Lid (True Blue) by Innate The beauty of the Innate modular system is that almost all of our accessories are interchangeable with any of our V2 collars. Mix and match your lids! |
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Disposable Wipes Sani-Cloth® HB Germicidal Disposable Wipes A quaternary/low alcohol formula (14.85%). Bactericidal, tuberculocidal and virucidal. Kills RSV in 1 minute, HBV, HCV and HIV-1 in 2 minutes and TB, MRSA, VRE in 5 minutes. Unique deep-well lid on canister seals securely to prevent moisture loss. by King Of Canes Disposable Wipes Sani-Cloth® HB Germicidal Disposable Wipes A quaternary/low alcohol formula (14.85%). Bactericidal, tuberculocidal and virucidal. Kills RSV in 1 minute, HBV, HCV and HIV-1 in 2 minutes and TB, MRSA, VRE in 5 minutes. Unique deep-well lid on canister seals securely to prevent moisture loss. |
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