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Antibody-altering protein found in developing B cells
July 20, 2007Why:
In order for the B cells of the immune system to identify and fight disease pathogens, they produce a protein called activation-induced cytidine deaminase (AID). Once a B cell is activated by the presence of a disease pathogen, it begins to make AID which directs and strengthens the B cells' response to the infection by mutating the antibodies produced by the B cells.
AID was originally thought to be made only by mature B cells and, as previously discovered by Imanishi-Kari and colleagues, in the developing B cells of transgenic mice. In the current article, Imanishi-Kari and colleagues reveal that AID is also made by developing B cells in wild-type, or normal, mice which implies that AID plays a larger role in the immune system than previously thought. Building upon what is already known about B cells, Imanishi-Kari hypothesizes that AID plays a role during B cell development by mutating B cell antibodies and, thereby, preventing B cells from mistaking some healthy human cells as disease pathogens, which is what occurs in autoimmune diseases such as systemic lupus erythematosus (SLE or lupus). Uncovering the presence of AID in developing B cells may offer a new direction for research into autoimmunity and other diseases.
Tufts University, Health Sciences
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