Progesterone therapy and preterm birth: More evidence helps identify women who can benefitAugust 02, 2007Two major studies published today in The New England Journal of Medicine can help doctors better identify pregnant women at risk for preterm delivery who can benefit from progesterone treatment, the March of Dimes Foundation said today. In one large multi-center trial led by Eduardo B. Fonseca, M.D., women with short cervix (most of whom had no prior history of preterm birth) who received progesterone suppository treatment between 24 and 34 weeks gestation had a greatly reduced rate of preterm birth. Another large multi-center trial led by Dwight J. Rouse, M.D., found that weekly injections of 17P (17 alpha-hydroxyprogesterone caproate, a derivative of progesterone) between 16 and 35 weeks gestation did not reduce the rate of preterm birth among women carrying twins.
"Premature birth is a growing problem in the United States and a leading killer of newborns," said Michael Katz, senior vice president for Research and Global Programs of the March of Dimes. "With this new information, physicians will have a better idea of how to identify those women who are most likely to benefit from progesterone treatment from those who are not." Dr. Katz noted that pathways to preterm birth may differ substantially between singleton and twin gestations. For example, progesterone may be more effective against some pathway that does not involve the uterine over-distention seen in twin pregnancy. "We need more research into the underlying causes of prematurity to help women with other risk factors," Dr. Katz said. March of Dimes Foundation | |||||||||||||||||||||
|
Related Progesterone Current Events and Progesterone News Articles Migraines associated with lower risk of breast cancer Women who suffer from migraines may take at least some comfort in a recent, first-of-its-kind study that suggests a history of such headaches is associated with a significantly lower risk of breast cancer. Breast cancer treatment resistance linked to signaling pathway Activation of the Src signaling pathway may cause resistance to standard medical treatment in some patients with breast cancer, and inhibition of this pathway holds the potential to overcome that resistance, according to data presented here at the American Association for Cancer Research Molecular Diagnostics in Cancer Therapeutic Development meeting. Gap junction protein vital to successful pregnancy, researchers find Researchers studying a critical stage of pregnancy - implantation of the embryo in the uterus - have found a protein that is vital to the growth of new blood vessels that sustain the embryo. Without this protein, which is produced in higher quantities in the presence of estrogen, the embryo is unlikely to survive. UNC trial: oral contraceptives may ease suffering of women with severe PMS A new clinical trial at the University of North Carolina at Chapel Hill using a popular low-dose contraceptive could uncover a more effective treatment for the 5 to 10 percent of women who suffer from premenstrual dysphoric disorder (PMDD). How advanced prostate cancer becomes resistant to androgen-deprivation therapy For the past 70 years the treatment of choice for advanced, metastatic prostate cancer has been androgen-deprivation therapy. Quest for better treatment for effects of menopause During menopause, lack of oestrogens increases the risk of suffering cardiovascular diseases. For her doctoral thesis, University of the Basque Country researcher, Ainhoa Ruiz del Agua, studied the effects of substitute treatments and the genetic factors influencing the response to these therapies. Global menopause summit concludes HRT is safe for healthy women entering menopause HRT in the early postmenopausal period is safe, and healthy women going through the first few years of the menopause who need HRT to relieve symptoms should have no fears about its use. Molecular 'clock' could predict risk for developing breast cancer A chemical reaction in genes that control breast cancer provides a molecular clock that could one day help researchers more accurately determine a woman's risk for developing breast cancer and provide a new approach for treatment, UT Southwestern Medical Center researchers have found. Treatment advances for fibroids, menopause Women with fibroids and endometriosis facing the possibility of hysterectomy may now choose less invasive treatment options to preserve fertility, according to Yale professor Aydin Arici, M.D., who will direct a scientific session exploring these alternatives at the American College of Obstetricians and Gynecologists (ACOG) Annual Clinical Meeting May 3-7 in New Orleans, Louisiana. Osteoporosis drug Fosamax linked to heart problem omen who have used Fosamax are nearly twice as likely to develop the most common kind of chronically irregular heartbeat (atrial fibrillation) than are those who have never used it, according to research from Group Health and the University of Washington published in the April 28 Archives of Internal Medicine. More Progesterone Current Events and Progesterone News Articles |
|||||||||||||||||||||
|
|||||||||||||||||||||
|
|||||||||||||||||||||