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Progesterone therapy and preterm birth: More evidence helps identify women who can benefit
August 02, 2007Two major studies published today in The New England Journal of Medicine can help doctors better identify pregnant women at risk for preterm delivery who can benefit from progesterone treatment, the March of Dimes Foundation said today.
In one large multi-center trial led by Eduardo B. Fonseca, M.D., women with short cervix (most of whom had no prior history of preterm birth) who received progesterone suppository treatment between 24 and 34 weeks gestation had a greatly reduced rate of preterm birth.
Another large multi-center trial led by Dwight J. Rouse, M.D., found that weekly injections of 17P (17 alpha-hydroxyprogesterone caproate, a derivative of progesterone) between 16 and 35 weeks gestation did not reduce the rate of preterm birth among women carrying twins.
"Premature birth is a growing problem in the United States and a leading killer of newborns," said Michael Katz, senior vice president for Research and Global Programs of the March of Dimes. "With this new information, physicians will have a better idea of how to identify those women who are most likely to benefit from progesterone treatment from those who are not."
Dr. Katz noted that pathways to preterm birth may differ substantially between singleton and twin gestations. For example, progesterone may be more effective against some pathway that does not involve the uterine over-distention seen in twin pregnancy.
"We need more research into the underlying causes of prematurity to help women with other risk factors," Dr. Katz said.
March of Dimes Foundation
"Premature birth is a growing problem in the United States and a leading killer of newborns," said Michael Katz, senior vice president for Research and Global Programs of the March of Dimes. "With this new information, physicians will have a better idea of how to identify those women who are most likely to benefit from progesterone treatment from those who are not."
Dr. Katz noted that pathways to preterm birth may differ substantially between singleton and twin gestations. For example, progesterone may be more effective against some pathway that does not involve the uterine over-distention seen in twin pregnancy.
"We need more research into the underlying causes of prematurity to help women with other risk factors," Dr. Katz said.
March of Dimes Foundation
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Source Naturals Natural Progesterone Cream, 4 oz (113.4 g) by Source Naturals Advanced liposomal delivery. Source Naturals eternal woman natural progesterone cream features natural progesterone USP from soy. Our progesterone cream is guaranteed to contain 500 mg of progesterone per ounce and 22 mg per 1/4 teaspoon. |
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Progesterone (Bio-Identical) Creme Plus Herbs - Fragrance Free/Unscented 8 oz. Pump Bottle by Radiant Laboratories - Made In USA Paraben-Free and Unscented. Replenish Your Progesterone Naturally and Safely. Don't suffer needessly with hot flashes and night sweats. Get your life back and feel good again. USP Progesterone from Wild Yam is Bio-identical to what is produced in the human body. The "Plus" is our Herbal Complex for Adrenal Gland Support. Feel Good Again! Hormone Replacement with Bio-Identical Hormones are Safe and Effective. WHY A CRÈME? Natural progesterone taken orally is mostly destroyed in the digestion process. Adequate absorption is only accomplished through topical application in a dermal delivery system. HAVE YOU EXPERIENCED ANY OF THESE SYMPTOMS? Migraines, Fatigue, Irritability, Cramping, Anxiety, Mood Swings, Depression, Fat Gain, Water Retention, Foggy Thinking, Breast Tenderness, Fibrocystic... |
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Emerita Pro-Gest Natural Progesterone Cream, Paraben-Free, 4-Ounce Tube by Emerita Peri/Menopause Support. Clinically - tested. Paraben - free. Does not contain any parabens. What's in it : Contains 450mg of USP Progesterone per ounce. Check the side of this box for a complete list of ingredients. What's not in it : No parabens, mineral oil, petroleum or animal anything. And our products are never tested on animals. Who knew this little cream could change the world. In 1978 we had a revolutionary idea: that there was not enough real choice when it came to peri / menopause support. So we created pro-gest to give women a much - deserved alternative. Made in the USA. |
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Life-Flo Progesta-Care Natural Progesterone Body Cream, Menopause Formula, 4-Ounce Bottle by Life-Flo Life-Flo Progesta-Care Natural Progesterone Body Cream Menopause Formula is physician developed and scientifically formulated. Each full press of the puM.D.ispenses 20 mg of natural progesterone USP. Progesta-Care is formulated to contain 480 mg of natural progesterone USP per ounce. (This product and these statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.) No animals were used to test this product. Manufactured in the USA. |
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Source Naturals Progesterone Cream Tube Liposomal Delivery, 4 ounce by Source Naturals Natural Progesterone Cream features natural progesterone USP from soy. This progesterone cream is guaranteed to contain 500 mg of progesterone per ounce and 22 mg per 1/4 teaspoon.* ... Progesterone is intended to support female balance before, during, and after menopause. It provides support for women of all ages who experience symptoms relating to PMS, menopause, and osteoporosis.* |
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Natural Progesterone Cream by C. Shealy (Author) Used to treat PMS, migraines, osteoporosis, and more. |
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Emerita - Pro-Gest Paraben Free, 4 oz cream by Emerita Complete ingredients:Water, Tocopheryl Acetate (Vit E), Aloe Barbadensis (Aloe Vera) Leaf Juice, Carthamus Tinctorius (Hybrid Safflower) Seed Oil, Panthenol, Glycerin, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Glyceryl Stearate, Cetyl Alcohol, Sodium Behenoyl Lactylate, Stearic Acid, USP Progesterone, Phenoxyethanol, Caprylyl Glycol, Sorbic Acid, Citrus Aurantium Dulcis (Orange) Oil, Citrus Medica Limonum (Lemon) Peel Oil, Carbomer This information is intended for educational purposes only. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent disease. |
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Natural USP Progesterone Cream, By PUH - 3 Oz by PHARMACISTS ULTIMATE HEALTH CORPORATION. PUH INDICATIONS: Natural USP Progesterone Cream - PMS and pre-menopausal women can benefit from Natural USP Progesterone to restore Hormonal Balance. Help Relieve Symptoms of PMS. |
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FemGest Progesterone Cream - 2 for 1, 4 oz by Home Health Fem-Gest Cream is a progesterone cream that is recommended to balance hormones and promote balance and harmony. |
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Life-Flo Progesta-Care Plus Natural Progesterone Body Cream, Menopause Solutions, with Phytoestrogens , 4 oz (113 g) by Life-Flo Physician developed & scientifically formulated. Each full press of the pump dispenses 20 mg of natural progesterone USP and 25 mg natural phytoestrogens. Progesta-Care Plus is formulated to contain 480 mg of natural progesterone USP and 600 mg of natural phytoestrogens per ounce. (This product and these statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.) No animals were used to test this product. Manufactured in the USA. |
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