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Chemotherapy with bevacizumab increases risk of blood clots in arteries
August 08, 2007Treatment with chemotherapy and bevacizumab, an anticancer drug, is associated with a greater risk of blood clots in patients' arteries compared with treatment with chemotherapy only, according to a study published online August 7 in the Journal of the National Cancer Institute.
The combination of chemotherapy and bevacizumab has been shown to increase survival in patients with metastatic colorectal and non-small-cell lung cancer, but some previous studies suggest these patients are at an increased risk for blood clots in their arteries.
Frank Scappaticci, M.D., Ph.D., of Genentech, Inc. in South San Francisco, Calif., and colleagues analyzed data from five randomized controlled trials that included 1,745 patients with metastatic colorectal, breast, or non-small-cell lung cancer.
Among patients treated with the combination therapy, 3.8 percent experienced blood clots in their arteries, compared with 1.7 percent of patients on chemotherapy alone. There was no statistically significant difference in the incidence of blood clots in veins. Risk factors for blood clots in both arteries and veins included previous blood clots and older age (65 or older.)
"The clinical benefit associated with bevacizumab therapy was maintained for all subgroups. Although death from [a blood clot in the artery] was uncommon, we did not capture functional disabilities from these events, and the risk factors-identified in this study should be considered when making treatment decisions for individual patients," the authors write.
Journal of the National Cancer Institute
Among patients treated with the combination therapy, 3.8 percent experienced blood clots in their arteries, compared with 1.7 percent of patients on chemotherapy alone. There was no statistically significant difference in the incidence of blood clots in veins. Risk factors for blood clots in both arteries and veins included previous blood clots and older age (65 or older.)
"The clinical benefit associated with bevacizumab therapy was maintained for all subgroups. Although death from [a blood clot in the artery] was uncommon, we did not capture functional disabilities from these events, and the risk factors-identified in this study should be considered when making treatment decisions for individual patients," the authors write.
Journal of the National Cancer Institute
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A study is under way at Rush University Medical Center using a small, soft-patch device made of a Gore-tex-type material - often used to make durable outerwear - to close a common hole found in the heart called a patent foramen ovale (PFO) in order to prevent recurrent strokes and transient ischemic attacks (TIAs) in adults.
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Nature study demonstrates that bacterial clotting depends on clustering
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Friend or foe? How the body's clot-busting system speeds up atherosclerosis
Sometimes it's hard to tell friends from foes, biologically speaking. Naturally produced in the body, urokinase plasminogen activator and plasminogen interact to break up blood clots and recruit clean-up cells to clear away debris related to inflammation. In fact, urokinase manufactured as a drug effectively clears clogged arteries by generating clot-busting plasmin from blood-derived plasminogen.
DNA research taking guesswork out of finding the 'therapeutic window'
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Heart failure patients have higher risk of fractures
Heart failure patients are at higher risk for fractures, including debilitating hip fractures, than other heart patients and should be screened and treated for osteoporosis, Canadian researchers reported in Circulation: Journal of the American Heart Association.
Stress tests to confirm need for cardiac stent not occurring in most patients, new study finds
UCSF researchers investigating the appropriate use of procedures to open narrowed coronary arteries -- such as angioplasty and stenting -- found that less than half of Medicare patients had documented noninvasive stress testing prior to elective percutaneous coronary intervention, or PCI, the clinical name for such procedures.
Triple antiplatelet therapy appears superior to dual antiplatelet therapy
Results of five research studies and a clinical registry first-report presentation scheduled for the 20th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation (CRF), suggest that triple antiplatelet therapy for patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents achieves greater platelet inhibition than conventional dual antiplatelet therapy.
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