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Spot on treatment for acne
August 13, 2007A previously unknown side effect of an unnamed drug currently on the marketplace could be useful for treating acne, reports Chemistry & Industry, the magazine of the SCI. A UK company is about to start a Phase 1 trial with the drug involving 18 healthy human volunteers and the results are expected to be announced later this year. In an earlier Phase 1 study in nine healthy human volunteers, the treatment was seen to reduce the excretion of sebum by the skin, which is associated with acne development, by up to 70%.
'The Phase I results are startlingly good,' said Nigel Blackburn, director of clinical development at the company, Summit, which is organising the trial. 'Reducing sebum production has been the "holy grail" of acne treatment for 30 years, and there has been little success aside from Roaccutane which has significant side effects.'
The current 'gold standard' for acne treatment, Roaccutane can cause a wide range of side effects, including teratogenicity - which leads to abonormalities in the unborn foetus of pregnant women, and has also recently been linked to depression and (inconclusively) to teenage suicides. The market for acne treatments is worth several billion dollars, and any new treatment developed without side effects could potentially reap blockbuster sales.
Although Summit has not disclosed the name of the drug now under evaluation, the company says it represents an entirely new class of compounds for treating acne. 'At the doses we are looking at any side effects should be mild compared with those resulting from Roaccutane treatment,' Blackburn commented.
The company hopes to begin critical Phase 2 trials to assess the efficacy of the drug in acne sufferers next year. Depending on the results, the drug could either be formulated as a stand-alone topical treatment or more likely in combination with other existing treatments. The company has already been in talks with several interested companies, who are waiting to see whether the initial results can be repeated in a larger study group.
Society of Chemical Industry
Although Summit has not disclosed the name of the drug now under evaluation, the company says it represents an entirely new class of compounds for treating acne. 'At the doses we are looking at any side effects should be mild compared with those resulting from Roaccutane treatment,' Blackburn commented.
The company hopes to begin critical Phase 2 trials to assess the efficacy of the drug in acne sufferers next year. Depending on the results, the drug could either be formulated as a stand-alone topical treatment or more likely in combination with other existing treatments. The company has already been in talks with several interested companies, who are waiting to see whether the initial results can be repeated in a larger study group.
Society of Chemical Industry
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Researchers from Boston University School of Medicine (BUSM) have concluded that the 940nm wavelength laser is superior for treating facial spider veins (telangiectasias) as compared to the 532nm wavelength laser.
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Skin-disease patients show brain immunity to faces of disgust
People with psoriasis - an often distressing dermatological condition that causes lesions and red scaly patches on the skin - are less likely to react to looks of disgust by others than people without the condition, new research has found.
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Retinoid cream associated with death in clinical trial, but relationship does not appear causal
Patients using a cream containing tretinoin, a retinoid commonly used to treat acne and other conditions, appeared more likely to die than those using a placebo in a clinical trial that was halted early as a result.
Happiness is infectious
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