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Can cancer drugs combine forces?
August 17, 2007Individuals with chronic myeloid leukemia (CML) are treated first with a drug known as imatinib (Gleevec), which targets the protein known to cause the cancer (BCR-ABL). If their disease returns, because BCR-ABL mutants emerge that are resistant to the effects of imatinib, individuals are treated with a drug known as dasatinib (SPRYCEL), which targets BCR-ABL in a different way. However, patients that relapse after treatment with dasatinib, because BCR-ABL mutants emerge that are resistant to the effects of this drug, are now beginning to be seen in the clinic. Researchers from Memorial Sloan-Kettering Cancer Center, New York, now suggest that treating patients with a combination of the drugs might decrease the chance of the cancer returning, or at the very least increase the time before a relapse occurs
In the study, which appears online on August 16 in advance of publication in the September print issue of the Journal of Clinical Investigation, Charles Sawyers and colleagues show that 2 of 12 patients whose cancer had returned after treatment with dasatinib responded to retreatment with imatinib. Analysis of the BCR-ABL proteins from these patients revealed that their BCR-ABL had only the dasatinib-resistance mutation. By contrast, the BCR-ABL proteins of the other patients had either a single mutation that rendered the protein resistant to both dasatinib and imatinib or had two mutations, one rendering the protein resistant to imatinib and one rendering the protein resistant to dasatinib. A third drug that can target dasatinib- and imatinib-resitant BCR-ABL is currently in clinical trials. The authors therefore suggest that rather than treating CML patients with the drugs that target BCR-ABL sequentially, they should receive all the drugs when they are first diagnosed with the disease so that the emergence of the drug-resistant forms of BCR-ABL might be prevented, or at least delayed.
Journal of Clinical Investigation
Cancer Drugs Current Events and Cancer Drugs News RSSNew imagining technique could lead to better antibiotics and cancer drugs
A recently devised method of imaging the chemical communication and warfare between microorganisms could lead to new antibiotics, antifungal, antiviral and anti-cancer drugs, said a Texas AgriLife Research scientist.
Taking aim at mysterious DNA structures in the battle against cancer
Designers of anti-cancer drugs are aiming their arrows at mysterious chunks of the genetic material DNA that may play a key role in preventing the growth and spread of cancer cells, according to an article in the current issue of Chemical & Engineering News, ACS' weekly newsmagazine.
Duke develops nano-scale drug delivery for chemotherapy
Going smaller could bring better results, especially when it comes to cancer-fighting drugs.
Next-generation microcapsules deliver 'chemicals on demand'
Scientists in California are reporting development of a new generation of the microcapsules used in carbon-free copy paper, in which capsules burst and release ink with pressure from a pen.
Sensor biochips could aid in cancer diagnosis and treatment
It is very difficult to predict whether a cancer drug will help an individual patient: only around one third of drugs will work directly in a given patient.
Melanoma treatment options 1 step closer
A targeted chemotherapy for the treatment of skin cancer is one step closer, after a team of University of Alberta researchers successfully synthesized a natural substance that shows exceptional potential to specifically treat this often fatal disease.
Experts issue call to reconsider screening for breast cancer and prostate cancer
Twenty years of screening for breast and prostate cancer - the most diagnosed cancer for women and men - have not brought the anticipated decline in deaths from these diseases, argue experts from the University of California, San Francisco and the University of Texas Health Science Center at San Antonio in an opinion piece published in the "Journal of the American Medical Association."
Metals could forge new cancer drug
Drugs made using unusual metals could form an effective treatment against colon and ovarian cancer, including cancerous cells that have developed immunity to other drugs, according to research at the University of Warwick and the University of Leeds.
Studying cancer in pet dogs to find new treatments for human patients
A team of scientists at the National Cancer Institute (NCI) in Bethesda, USA, says that studying pet dogs with cancer could yield valuable information on how to diagnose and treat human cancers.
KEAP1 Keeps major cancer-promoting protein at bay
A tumor-suppressing protein snatches up an important cancer-promoting enzyme and tags it with molecules that condemn it to destruction, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports this week in the journal Molecular Cell.
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Physicians' Cancer Chemotherapy Drug Manual: 2009 by Edward Chu (Author), Vincent DeVita Jr. (Author) Completely revised and updated for 2009, the Physicians Cancer Chemotherapy Drug Manual is an up-to-date guide to the latest information on standard therapy and recent advances in the field. Written by world-class experts in the clinical cancer therapeutics, this essential reference provides a complete, easy-to-use catalogue of over 100 drugs and commonly used drug regimens both on-and off-label for the treatment of all the major cancers. Special features: Features new drugs: Bendamustine, Ixabepilone, and Nilotinib; Revised to reflect rapid advances in the field, incorporating new drug and treatment strategies; diagrams of drug structures and pathways for each agent; Offers a comprehensive discussion of clinical pharmacology, special considerations, indications, and dosages; Covers... |
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Drugs That Fight Cancer / TIME Cover: May 28, 2001, Art Poster by TIME Magazine by barewalls The most eagerly awaited event in the editorial cycle at TIME Magazine is always the selection of the cover. The best covers capture the zeitgeist of the week while surviving the judgment of history. As browsing this collection of TIME cover art prints shows, TIME is as good a record as any of who and what mattered over the past 80-plus years. And so when TIME captures a person, an event or a trend within its iconic red borders, the magazine is adding that extra dose of significance that no other publication can quite match. That is one reason why the original artwork for more than 800 TIME covers now resides in the National Portrait Gallery in Washington. Thanks to an amazing roster of artists, photographers and graphic designers, from TIME's earliest charcoal drawings of cover subjects... |
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Surviving Terminal Cancer: Clinical Trials, Drug Cocktails, and Other Treatments Your Oncologist Won't Tell You About by Ben A. Williams (Author) (Fairview Press) Univ. of California, San Diego. Consumer text explains how patients can improve their odds for survival by demanding control over their health care, research conventional and alternative treatments, creating their own treatment strategy, and using the Internet to learn of new medical advances. Softcover. |
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BMV Quantum Subliminal CD Chemotherapy Aid (Ultrasonic Peak Health Series) Program your subconscious mind to maximize your health, improve self-healing during the chemotherapy process and reduce negative symptoms and negative side-effects related to chemo treatment. Using exclusive state-of-the-art subliminal and brainwave entrainment technologies, you can program your subconscious mind for positive lasting results, created by a Certified Hypnotherapist and NLP Practitioner (Neuro-Linguistic Programming). Silent affirmations, inaudible hypnotic suggestions and thousands of powerful subliminal messages program your subconscious mind for positive results. The first 3 tracks have an ocean background. The Silent Ultrasonic Track 4 is completely silent with no sound at all! BMV exclusive Quantum Subliminal Matrix Technology sets a new standard for the subliminal... |
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He Loves Me - He Loves Me Not (DVD) by Lorraine Day, M.D. |
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