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Specific antagonism lowers blood pressure
August 17, 2007High blood pressure (hypertension) is associated with an increased risk of heart attack and stroke, and the frequent use of drugs known as NSAIDs, for example to treat individuals with rheumatoid arthritis, can cause hypertension. Exactly why NSAIDs cause hypertension is not clear because they inhibit the generation of several soluble factors (known as prostaglandins) that can affect blood pressure and the effects of inhibiting the individual receptors for prostaglandins are not known. In an attempt to address this issue researchers from Vanderbilt University Medical Center identified a novel potential target for the treatment of hypertension.
In the study, which appears online on August 16 in advance of publication in the September print issue of the Journal of Clinical Investigation, Matthew Breyer and colleagues show that inhibitors of the prostaglandin E2 receptor EP1 reduce hypertension in rats. Consistent with this, mice lacking EP1 were protected from the hypertensive effects of angiotensin II and EP1-specific agonists. The authors therefore suggest that targeting the PGE2 receptor EP1 might be a viable approach to treating hypertension.
Journal of Clinical Investigation
Hypertension Current Events and Hypertension News RSSVery low birth weight is a risk factor for 1 cause of CKD
Individuals who were underweight at birth are at increased risk of developing a condition called secondary focal segmental glomerulosclerosis, according to a study appearing in the January 2009 issue of the Clinical Journal of the American Society Nephrology (CJASN).
Routine Testing After Aneurysm Coiling Carries Low Risk
A very low risk of complication is associated with a routine test that determines whether a brain aneurysm treated with endovascular coiling has started to recur, a study led by the University of Cincinnati Neuroscience Institute has shown.
Low risk for heart attack? Could an ultrasound hold the answer?
By adding the results of an imaging technique to the traditional risk factors for coronary heart disease, doctors at Baylor College of Medicine in Houston found they were able to improve prediction of heart attacks in people previously considered low risk.
Study shows direct link between leptin and obesity-related cardiovascular disease
Obese people who don't have high cholesterol or diabetes might think they're healthy - despite the extra pounds.
Low-dose aspirin does not appear to reduce risk of CV events in patients with diabetes
Low-dose aspirin as primary prevention did not appear to significantly reduce the risk of a combined end point of coronary, cerebrovascular and peripheral vascular events in patients with type 2 diabetes, according to a new study in JAMA.
Pregnancy diabetes doubles the risk of language delay in children
Children born to mothers with pregnancy-related diabetes run twice the risk of language development problems, according to a research team directed by Professor Ginette Dionne of Université Laval's School of Psychology. Details of this discovery are published in the most recent issue of the scientific journal Pediatrics.
Pregnancy disorder signals need to screen for heart disease, study shows
High blood pressure experienced during pregnancy could be a woman's earliest warning that she is at risk of developing heart disease - the number one killer of Canadian women - says Queen's University professor of Obstetrics and Gynecology, Graeme Smith.
Mounting evidence shows health benefits of grape polyphenols
A growing body of research data suggests that consuming foods rich in polyphenols from grapes, including red wine, helps reduce the risk of heart disease, according to a review article in the November issue of Nutrition Research.
Grapes may aid a bunch of heart risk factors, animal study finds
Could eating grapes help fight high blood pressure related to a salty diet? And could grapes calm other factors that are also related to heart diseases such as heart failure? A new University of Michigan Cardiovascular Center study suggests so.
Green neighborhoods may reduce childhood obesity
Childhood obesity can lead to type 2 diabetes, asthma, hypertension, sleep apnea and emotional distress. Obese children and youth are likely to be obese as adults, experience more cardiovascular disease, high blood pressure and stroke and incur higher healthcare costs.
More Hypertension Current Events and Hypertension News Articles
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 | Reversing Hypertension: A Vital New Program to Prevent, Treat, and Reduce High Blood Pressure by Julian Whitaker It strikes one in four North Americans without warning it triples your risk of dying from a heart attack it increases your risk of stroke sevenfold it can lead to kidney disease, diabetes, and blindness and to fight it, you may be taking expensiveand dangerousdrugs. Now Dr. Julian Whitaker, a leading champion of nutritional medicine unleashes a new weapon in the war against... |
 | Pulmonary Hypertension (Contemporary Cardiology) (Contemporary Cardiology) This timely volume addresses the areas of pathophysiology and therapy of pulmonary hypertension, which have seen exciting developments over the past decade. The discoveries of endothelin overexpression as well as prostacyclin and nitric oxide deficiency in association with pulmonary hypertension have led to important therapeutic insights. In addition, the identification of genes associated with... |
 | The DASH Diet for Hypertension by Thomas J. Moore, Mark Jenkins More than 50 million Americans suffer from high blood pressure, and most of them control it by taking prescription drugs with potentially dangerous side effects. But there is a natural, affordable, and easy-to-manage alternative to medication: the DASH (Dietary Approaches to Stop Hypertension) diet. Developed by a world-class team of doctors and nutritionists, the DASH diet is clinically proven... |
 | Hypertension Primer: The Essentials of High Blood Pressure: Basic Science, Population Science, and Clinical Management Now in its thoroughly updated Fourth Edition, the Hypertension Primer is a comprehensive, readable source of state-of-the-art scientific and clinical information on hypertension. The book contains 171 short chapters by distinguished experts that cover every aspect of hypertension and its pathogenesis, epidemiology, impact, and management. Highlights of this edition include updated JNC 7 findings... |
 | Pulmonary Arterial Hypertension: Diagnosis and Evidence-Based Treatment First book dedicated to this disease, previously thought to be incurable, but with the advent of new drugs, now amenable to management and a much improved prognosis for patients From the PAH Association, the leading experts in field Incorporates the latest AACP management guidelines Includes evidence-based treatment algorithms based on the recently updated ACCP Guidelines for... |
 | Oxford American Handbook of Nephrology and Hypertension (Oxford American Handbooks in Medicine) by Paul Scheel, Michael Choi Written by leading American practitioners, the Oxford American Handbooks of Medicine each offer a pocket-sized overview of an entire specialty, featuring instant access to guidance on the conditions that are most likely to be encountered. Precise and prescriptive, the handbooks offer up-to-date advice on examination, investigations, common procedures, and in-patient care. These books will be... |
 | The Heartmath Approach to Managing Hypertension: The Proven, Natural Way to Lower Your Blood Pressure (Heartmath) by Bruce C., M.D. Wilson, Doc Childre High blood pressure is a national epidemic. It’s a silent killer, a dangerous condition that affects one in four Americans, most of whom have no idea they are at risk for higher rates of heart disease, stroke, and other life-threatening problems. Conventional treatments for hypertension involve drugs, and these can have considerable side effects and may not be ultimately succeed in getting... |
 | The Effects of Yoga on Hypertension by Swami Shankardevananda Hypertension is one of many pschosomatic diseases which can be treated through a combination of yoga and traditional medicine.This disease is a symbol of other maladies from which mankind currently suffers and which cause seemingly endless suffering.The root cause of all diseases is the same:ignorance of our true nature and lack of awareness of who we really are. This Book will help one... |
 | Healing Hypertension: A Revolutionary New Approach by Samuel J. Mann A PIONEERING APPROACH TO OVERCOMING HIGH BLOOD PRESSURE If you are one of the millions of people diagnosed with high blood pressure, this groundbreaking book can change your life. Unique in combining a medical and a psychological approach, Samuel J. Mann, M.D., explains:How you can tell whether or not your high blood pressure is related to emotionsHow to find the medication best suited for... |
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