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Inhaling helps heal liver transplant recipients
August 24, 2007A new report from a team of researchers at the University of Washington, Seattle, and the University of Alabama at Birmingham indicates that one of the main complications of liver transplantation can be treated very simply by allowing the transplant recipients to inhale nitric oxide (NO) during the operation in which they received their new liver. Inhalation of NO decreased the length of time the patients had to stay in hospital and increased the rate at which the function of the transplanted liver was restored, leading the authors to suggest that inhalation of NO is a valuable preemptive approach to enhancing liver function after transplantation.
The authors chose to investigate the potential benefits of NO inhalation to liver transplant recipients because ischemia/reperfusion damage, which is one of the main causes of liver dysfunction and failure after transplantation, is associated with decreased NO production by the liver. The study was prospective, blinded, and placebo-controlled and clearly showed that inhaling NO was beneficial to the transplant recipients. Further analysis indicated that the beneficial effects of inhaled NO were probably mediated through increased levels of nitrite in the circulation. Although these results are extremely promising, the authors caution that further studies using a larger number of patients are needed before a final conclusion about the benefits of inhaling NO can be reached.
Journal of Clinical Investigation
Transplant Recipients Current Events and Transplant Recipients News RSSChildren's Hospital study demonstrates how bone marrow transplant can cure sickle cell disease
A unique approach to bone marrow transplantation pioneered in part by a Children's Hospital of Pittsburgh of UPMC physician has proven to be the only safe and effective cure for sickle cell disease, according to a new study.
African-American Canadians who receive kidney transplants fare better than those in US
African American kidney disease patients in both Canada and the United States are less likely than Caucasian Americans to have access to kidney transplants, but only African-Americans in the United States have worse health outcomes than Caucasians after a transplant is performed.
Study Shows Steroid Therapies Following Transplant Can Be Eliminated
A new study by researchers at UC shows that using modern immunosuppressive drugs eliminates the need for steroid therapy as early as seven days following a transplant surgery while still maintaining kidney function
Children's Hospital researchers identify genetic mutation that may predict organ rejection
Using a novel combination of cutting-edge technologies to scan the human genome, researchers at Children's Hospital of Pittsburgh of UPMC have identified a genetic mutation that identifies transplant recipients who experience rejection.
CMV infections affect more than just patients with compromised immune systems, researchers find
An infection due to a virus called cytomegalovirus (CMV), which most commonly affects people with compromised immune systems, can also affect hospital intensive-care patients who have no immune-system problems, University of Washington researchers have found.
'Statins' linked to improved survival in kidney transplant recipients
For patients receiving kidney transplants, treatment with cholesterol-lowering "statin" drugs may lead to longer survival, reports a study in the November 2008 Journal of the American Society of Nephrology (JASN).
Predicting the risk of a common fungal infection after stem cell transplantation
In silico genetic analysis in mice has led to the discovery of a gene affecting susceptibility to a severe fungal infection in transplant recipients.
Anti-rejection drug may increase risk of diabetes after kidney transplant
For patients undergoing kidney transplantation, treatment with the anti-rejection drug sirolimus may lead to an increased risk of diabetes, reports a study in the July Journal of the American Society of Nephrology (JASN).
Study concludes no racial disparities in long-term outcomes in recipients of liver transplants
New research published in the Journal of the American College of Surgeons shows long-term survival and liver rejection rates are equivalent for African-American liver transplant patients as compared with patients of other races.
Depression and PTSD symptoms in caregivers of lung transplant patients
Symptoms of depression and post-traumatic stress disorder (PTSD) among caregivers of deceased lung transplant patients are four-to-five times more prevalent than in the average population, according to researchers who analyzed the stress levels of caregivers, as well as their perceptions of the transplant recipients' quality of dying and death.
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