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New technique can be breakthrough for early cancer diagnosis
September 12, 2007Early detection of disease is often critical to how successful treatment can be. Therefore, the development of new methods of diagnosis is a hot research field, where every small step is of great importance. In an article in the latest issue of Molecular & Cellular Proteomics, Uppsala University researchers describe a technique that the journal regards as especially interesting.
Proteins build up the body's cells and tissues, and our knowledge of the human genome also entails that today's scientists are aware of all of the proteins that our body can produce. It is known that many morbid conditions can be linked to changes in proteins, so it is important to enhance our knowledge of what proteins bind to each other, how they work together, and how processes are impacted by various disturbances.
In 2006 Ola Söderberg and his colleagues at the Department of Genetics and Pathology devised a new technique, in situ PLA (in situ proximity ligation assay), that could detect communication between proteins in cells. These researchers have now refined the method and can now see how proteins undergo change inside a cell.
"The method provides a better potential to truly understand how proteins function in the cell and can show what is wrong with a sick cell, as in cancer, for instance. The refined method has the potential to revolutionize cancer diagnostics, so there has been a great deal of interest in the method from the research community," says Ola Söderberg.
The technique is more sensitive and more reliable than other available techniques in molecular diagnostics, and it has already started to be sold by the Uppsala company Olink, so there are high hopes that it will soon be used in health care.
Uppsala University
"The method provides a better potential to truly understand how proteins function in the cell and can show what is wrong with a sick cell, as in cancer, for instance. The refined method has the potential to revolutionize cancer diagnostics, so there has been a great deal of interest in the method from the research community," says Ola Söderberg.
The technique is more sensitive and more reliable than other available techniques in molecular diagnostics, and it has already started to be sold by the Uppsala company Olink, so there are high hopes that it will soon be used in health care.
Uppsala University
Proteins Current Events and Proteins News RSSScientists at UA, collaborating institutions decode maize genome
Scientists from the University of Arizona led by Arizona Genomics Institute director Rod A. Wing and from collaborating institutions have deciphered the complete genetic code of the maize plant for the first time.
On the Trail of a Vaccine for Lyme Disease: Yale Researchers Target Tick Saliva
A protein found in the saliva of ticks helps protect mice from developing Lyme disease, Yale researchers have discovered. The findings, published in the November 19 issue of Cell Host & Microbe, may spur development of a new vaccine against infection from Lyme disease, which is spread through tick bites.
Smithsonian scientists find the frog legs trade may facilitate spread of pathogens
Most countries throughout the world participate in the $40-million-per-year culinary trade of frog legs in some way, with 75 percent of frog legs consumed in France, Belgium and the United States.
Causative gene of a rare disorder discovered by sequencing only protein-coding regions of genome
For the first time, scientists have successfully used a method called exome sequencing to quickly discover a previously unknown gene responsible for a mendelian disorder.
An atomic-level look at an HIV accomplice
Since the discovery in 2007 that a component of human semen called SEVI boosts infectivity of the virus that causes AIDS, researchers have been trying to learn more about SEVI and how it works, in hopes of thwarting its infection-promoting activity.
New research into the mechanisms of gene regulation
A team led by Penn State's Ross Hardison, T. Ming Chu Professor of Biochemistry and Molecular Biology, has taken a large step toward unraveling how regulatory proteins control the production of gene products during development and growth.
Cancers' Sweet Tooth May Be Weakness
The pedal-to-the-metal signals driving the growth of several types of cancer cells lead to a common switch governing the use of glucose, researchers at Winship Cancer Institute of Emory University have discovered.
Toward explaining why hepatitis B hits men harder than women
Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women.
Saliva proteins change as women age
In a step toward using human saliva to tell whether those stiff joints, memory lapses, and other telltale signs of aging are normal or red flags for disease, scientists are describing how the protein content of women's saliva change with advancing age.
Scientists find molecular trigger that helps prevent aging and disease
Researchers at Mount Sinai School of Medicine set out to address a question that has been challenging scientists for years: How do dietary restriction-and the reverse, overconsumption-produce protective effects against aging and disease?
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Worldwide Pure Protein High Protein Bar, Chocolate Peanut Butter, 2.75-Ounce Bars (Pack of 12) by WorldWide The Pure Protein bar is packed with 32 grams of protein. Naturally and artificially flavored, this meal replacement bar comes with a chocolate peanut butter taste. |
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Clif Builder's Bar, Protein Bar, Peanut Butter, 2.4-Ounce Bars (Pack of 12) by Clif Bar The Cocoa Dipped, Double-Decker Crisp Clif Builder's Bar, is the first delicious high protein bar to pay tribute to those who turn their everyday world into a gym. Clif Builder's will fuel your muscles with added protein, especially when your day requires a little extra oomph. When work feels like a workout. |
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Designer Whey The Biggest Loser Protein - Red Raspberry, 10-Ounce Canister by DESIGNER WHEY Designer Whey's The Biggest Loser Protein contain 8grams of Whey Protein Isolate per serving with 6grams of Prebiotc fiber to help curb hunger. Low in calories with only 40 caloreis per serving and 0grams of fat! Calcium has been addded for to aid in fat loss and bone health |
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Kellogg's Special K Protein Meal Bar Double Chocolate, 6-Count Boxes (Pack of 3) by Kellogg's Double Chocolate Special K Protein Meal Bars are a convenient way to resist temptations because you'll feel fuller longer. With 10 grams of protein and 5 grams of fiber, a deliciously decadent chocolate flavor, choclolatey chips, crisp-crunchy rice, and a rich chocolatey coating, you'll enjoy every bite as you manage your shape. |
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