 |
|
New technique can be breakthrough for early cancer diagnosis
September 12, 2007Early detection of disease is often critical to how successful treatment can be. Therefore, the development of new methods of diagnosis is a hot research field, where every small step is of great importance. In an article in the latest issue of Molecular & Cellular Proteomics, Uppsala University researchers describe a technique that the journal regards as especially interesting.
Proteins build up the body's cells and tissues, and our knowledge of the human genome also entails that today's scientists are aware of all of the proteins that our body can produce. It is known that many morbid conditions can be linked to changes in proteins, so it is important to enhance our knowledge of what proteins bind to each other, how they work together, and how processes are impacted by various disturbances.
In 2006 Ola Söderberg and his colleagues at the Department of Genetics and Pathology devised a new technique, in situ PLA (in situ proximity ligation assay), that could detect communication between proteins in cells. These researchers have now refined the method and can now see how proteins undergo change inside a cell.
"The method provides a better potential to truly understand how proteins function in the cell and can show what is wrong with a sick cell, as in cancer, for instance. The refined method has the potential to revolutionize cancer diagnostics, so there has been a great deal of interest in the method from the research community," says Ola Söderberg.
The technique is more sensitive and more reliable than other available techniques in molecular diagnostics, and it has already started to be sold by the Uppsala company Olink, so there are high hopes that it will soon be used in health care.
Uppsala University
"The method provides a better potential to truly understand how proteins function in the cell and can show what is wrong with a sick cell, as in cancer, for instance. The refined method has the potential to revolutionize cancer diagnostics, so there has been a great deal of interest in the method from the research community," says Ola Söderberg.
The technique is more sensitive and more reliable than other available techniques in molecular diagnostics, and it has already started to be sold by the Uppsala company Olink, so there are high hopes that it will soon be used in health care.
Uppsala University
Proteins Current Events and Proteins News RSSMisreading of damaged DNA may spur tumor formation
The DNA in our cells is constantly under assault from oxygen, the sun's radiation and environmental stresses. Most of the time, our cells can repair the damage before it gets copied into a permanent mutation that could lead to cancer.
Red, red wine: How it fights Alzheimer's
Scientists call it the "French paradox" - a society that, despite consuming food high in cholesterol and saturated fats, has long had low death rates from heart disease.
Systems biology brings hope of speeding up drug development
Almost every day brings news of an apparent breakthrough against cancer, infectious diseases, or metabolic conditions like diabetes, but these rarely translate into effective therapies or drugs, and even if they do clinical development usually takes well over a decade.
Biomedical research profits from the exploration of the deep sea
A study published in the scientific journal PLoS ONE highlights how the exploration of the ocean depths can benefit humankind.
Biomedical research profits from the exploration of the deep sea
A study published in the scientific journal PLoS ONE highlights how the exploration of the ocean depths can benefit humankind.
New platinum-phosphate compounds kill ovarian cancer cells
A new class of compounds called phosphaplatins can effectively kill ovarian, testicular, head and neck cancer cells with potentially less toxicity than conventional drugs, according to a new study published this week in the journal Proceedings of the National Academy of Sciences.
New insight into the controls on a go-to enzyme
Scientists at St. Jude Children's Research Hospital have gained new insights into regulation of one of the body's enzyme workhorses called calpains.
Common cold virus came from birds
A virus that causes cold-like symptoms in humans originated in birds and may have crossed the species barrier around 200 years ago, according to an article published in the December issue of the Journal of General Virology. Scientists hope their findings will help us understand how potentially deadly viruses emerge in humans.
JDRF funded research shows promise for prevention, reversal of type 1 diabetes
Researchers at the University of California, San Francisco have reported that two common cancer drugs have been used to block and reverse type 1 diabetes in mice.
Science teams at Cold Spring Harbor Laboratory identify 13 new tumor-suppressor genes in liver cancer
Over the years, hunting for cancer-related genes and understanding how they work has been an important, although time-consuming, exercise. At Cold Spring Harbor Laboratory (CSHL), five different research groups have now combined their expertise to speed up the rate of discovering cancer-related genes and validating their function in living animals.
More Proteins Current Events and Proteins News Articles
 | Protein Power: The High-Protein/Low-Carbohydrate Way to Lose Weight, Feel Fit, and Boost Your Health--in Just Weeks! by Michael R. Eades, Mary Dan Eades Join the thousands who have experienced dramatic weight loss, lowered cholesterol, and improvement or reversal of the damages of heart disease, adult-onset diabetes, and other major diseases by following this medically proven program.Protein Power will teach you how to use food as a tool for Dramatic and permanent weight loss Resetting your metabolism and boosting your energy levels Lowering your... |
 | The Protein Power Lifeplan by Michael R. Eades, Mary Dan Eades The authors of Protein Power are back to advocate the "protein-rich, moderate-fat, carbohydrate-restricted diet" that opposes the high-carbohydrate, low-fat diet that every professional medical and dietetic organization (including those who have no diet books to sell) believes to be your best bet for avoiding heart disease, the number one killer. The authors insist, in the face of all this... |
 | The Protein Power Lifeplan Gram Counter by Michael R. Eades, Mary Dan Eades |
 | The Protein Counter (2nd Edition) by Annette B. Natow, Jo-Ann Heslin MORE THAN 3.5 MILLION NATOW & HESLIN COUNTER BOOKS IN PRINTDISCOVER HOW TO PUT PROTEIN TO WORK FOR YOUEvery day your body needs protein to build and replace millions of cells. And your need for protein goes up during stress, exercise, weight loss, illness, injury, pregnancy, and after surgery. Now, the two nationally recognized registered dietitians and nutritionists who created the national... |
 | The Oil Protein Diet Cookbook by Johanna Budwig The Oil Protein Diet CookbookBy Dr. Johanna BudwigContemporary nutritional science owes a great deal to Dr. Budwig's early discoveries on Fat Metabolism and Healing. This brilliant scientific mind has put together a wonderfully imaginative "cookbook" - a practical guide for the use of oils in daily meal preparation. Discover over 500 delicious meal possibilities using the healing powers of Flax... |
 | The High-Protein Cookbook: More than 150 healthy and irresistibly good low-carb dishes that can be on the table in thirty minutes or less. by Linda West Eckhardt, Katherine West Defoyd End food boredom and diet burnout with more than 400 sophisticated, low-carbohydrate dinners that are bursting with flavor--and on the table in under 30 minutes!Hundreds of thousands have embraced the low-carbohydrate lifestyle finding that a diet based on lean protein, fruits, and vegetables and less dependent on simple carbohydrates has helped them look and feel better. But a monotonous menu of... |
 | C-Reactive Protein : Everthing You Need to Know About It and Why It's More Important Than Cholesterol to Your Health by Scott J. Deron The first comprehensive resource on CRP--a powerful new way to assess heart attack risk Half of all heart attacks and strokes occur in people with normal cholesterol levels--a phenomenon that has long baffled doctors. C-Reactive Protein, or CRP, is a newly discovered measure of inflammation in the body that some researchers believe is twice as important as cholesterol in predicting one's... |
 | Protein NMR Spectroscopy: Principles and Practice by John Cavanagh, Wayne J. Fairbrother, III, Arthur G. Palmer, Nicholas J. Skelton, Mark Rance Protein NMR Spectroscopy combines a comprehensive theoretical treatment of NMR spectroscopy with an extensive exposition of the experimental techniques applicable to proteins and other biological macromolecules in solution. Beginning with simple theoretical models and experimental techniques, Protein NMR Spectroscopy develops the complete repertoire of theoretical principles and experimental... |
 | Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding by Alan Fersht By concentrating on fundamental principles and the physical and chemical processes behind them, Structure and Mechanism in Protein Science makes the basic formulas, Kinetics, and thermodynamics of protein engineering easier to understand and apply. Up-to-date, authoritative, and full of relevant examples, it provides a solid introduction to a sprawling, still-growing... |
 | The Turbo Protein Diet: Stop Yo-Yo Dieting Forever by Dieter Market Staff Stop Yo-Yo Dieting Forever! The book that explains how an initial plan of liquid nourishment composed of primarily vegetarian proteins cleanses the body in preparation for the moderate exercise program and healthy meal plan explained in detail. This diet ends the frustration of repeated failure, bringing a healthy, slim body within anyone's reach. Powder sold... |
| © 2008 BrightSurf.com |